ID A0A1L8EMZ6_XENLA Unreviewed; 229 AA.
AC A0A1L8EMZ6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Growth factor receptor-bound protein 2-B isoform X1 {ECO:0000313|RefSeq:XP_041433679.1};
GN Name=grb2.S {ECO:0000313|RefSeq:XP_041433679.1,
GN ECO:0000313|Xenbase:XB-GENE-6070021};
GN Synonyms=EGFRBP-GRB2 {ECO:0000313|RefSeq:XP_041433679.1}, grb2
GN {ECO:0000313|RefSeq:XP_041433679.1}, grb2-a
GN {ECO:0000313|RefSeq:XP_041433679.1}, grb2-b
GN {ECO:0000313|RefSeq:XP_041433679.1}, Grb3-3
GN {ECO:0000313|RefSeq:XP_041433679.1}, MST084
GN {ECO:0000313|RefSeq:XP_041433679.1}, MSTP084
GN {ECO:0000313|RefSeq:XP_041433679.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041433679.1};
RN [1] {ECO:0000313|RefSeq:XP_041433679.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041433679.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041433679.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001085669.1; NM_001092200.1.
DR RefSeq; XP_018092944.1; XM_018237455.1.
DR RefSeq; XP_041433679.1; XM_041577745.1.
DR AlphaFoldDB; A0A1L8EMZ6; -.
DR SMR; A0A1L8EMZ6; -.
DR STRING; 8355.A0A1L8EMZ6; -.
DR PaxDb; 8355-A0A1L8EMZ6; -.
DR GeneID; 444095; -.
DR KEGG; xla:444095; -.
DR AGR; Xenbase:XB-GENE-6070021; -.
DR CTD; 444095; -.
DR Xenbase; XB-GENE-6070021; grb2.S.
DR OMA; WAVKFNS; -.
DR OrthoDB; 25371at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 444095; Expressed in spleen and 19 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd09941; SH2_Grb2_like; 1.
DR CDD; cd11949; SH3_GRB2_C; 1.
DR CDD; cd11946; SH3_GRB2_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR035643; GRB2_C_SH3.
DR InterPro; IPR035641; GRB2_N_SH3.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF4; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Receptor {ECO:0000313|RefSeq:XP_041433679.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
SQ SEQUENCE 229 AA; 26363 MW; 27892646BDE92C98 CRC64;
MEAIAKYDFK ATADDELSFK RGDVLKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQVHGG DRATSLPQQP TFVQALFDFD
PQEDGELGFR RGDFIQVVDN SDPNWWKGTC LGQTGMFPRN YVTPVNRNM
//
