ID A0A1L8EN54_XENLA Unreviewed; 602 AA.
AC A0A1L8EN54;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
GN Name=ntn1.S {ECO:0000313|Xenbase:XB-GENE-17338479};
GN Synonyms=ntn1.L {ECO:0000313|RefSeq:XP_018094069.1,
GN ECO:0000313|RefSeq:XP_018094070.1, ECO:0000313|RefSeq:XP_018094071.1,
GN ECO:0000313|RefSeq:XP_018094072.1, ECO:0000313|RefSeq:XP_018094073.1,
GN ECO:0000313|RefSeq:XP_041433902.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018094069.1};
RN [1] {ECO:0000313|RefSeq:XP_018094069.1, ECO:0000313|RefSeq:XP_018094070.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018094069.1,
RC ECO:0000313|RefSeq:XP_018094070.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018094069.1,
RC ECO:0000313|RefSeq:XP_018094070.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
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DR RefSeq; XP_018094069.1; XM_018238580.2.
DR RefSeq; XP_018094070.1; XM_018238581.2.
DR RefSeq; XP_018094071.1; XM_018238582.2.
DR RefSeq; XP_018094072.1; XM_018238583.2.
DR RefSeq; XP_018094073.1; XM_018238584.2.
DR RefSeq; XP_041433902.1; XM_041577968.1.
DR STRING; 8355.A0A1L8EN54; -.
DR PaxDb; 8355-A0A1L8EN54; -.
DR GeneID; 373694; -.
DR KEGG; xla:373694; -.
DR AGR; Xenbase:XB-GENE-17338479; -.
DR AGR; Xenbase:XB-GENE-989336; -.
DR CTD; 373694; -.
DR Xenbase; XB-GENE-17338479; ntn1.S.
DR OMA; ESHPESM; -.
DR OrthoDB; 2916807at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 373694; Expressed in brain and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..602
FT /note="Netrin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041053262"
FT DOMAIN 45..282
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 402..451
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 470..599
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 402..414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 404..421
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 423..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 435..449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 602 AA; 68139 MW; B7547C95FEA5B870 CRC64;
MLRCQLVFVL VSLSCTAQEG RGGYGMNMFS IQTSQPDPCY DENGNPRRCI PDFVNSAFGK
DVKVSSTCGK PQSRYCVVTE KGEDRFRNCH ICNMSDPKRA HPPSFLTDLN NPHNLTCWQS
ENYIQYPQNV TLTLSLGKKF EVTYVSLQFC SPRPESMAIF KSMDYGKSWV PFQFYSTQCR
KMYNKPNKAI ITKQNEQEAI CTDSHTDMHP LSGGLIAFST LDGRPSAHDF DNSPVLQDWV
TATDIKVAFS RLHTFGDENE DDSELARDSY FYAVSDLQVG GRCKCNGHAS RCVKDRDDNL
VCDCKHNTAG PECDRCKPFH YDRPWQRATA REANECVACN CNLHARRCRF NMELFKLSGR
RSGGVCLNCR HNTAGRHCHY CKEGYYRDMT KAITHRKACK ACDCHPVGAA GKTCNQTTGQ
CPCKDGVTGI TCNRCAKGYQ QSRSPIAPCI KIPVVPPTTA ASSTEEPADC DIYCKASKGK
LKINMKKYCK KDYAVQIHIL KAEKAGDWWK FTVNVISVYK QGTNRIRRGD QNLWIRSKDI
ACKCPKLKPM KKYLLLGNDE DSPDQNGVVA DKTSLVIQWR DTWARRLRKF QQREKKGKCK
KA
//
