ID A0A1L8ENA8_XENLA Unreviewed; 326 AA.
AC A0A1L8ENA8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Voltage-dependent calcium channel gamma-4 subunit {ECO:0000256|RuleBase:RU363085};
GN Name=cacng4.S {ECO:0000313|RefSeq:XP_018093160.1,
GN ECO:0000313|Xenbase:XB-GENE-6487840};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018093160.1};
RN [1] {ECO:0000313|RefSeq:XP_018093160.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018093160.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018093160.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC contain CACNA1C as pore-forming subunit (By similarity). Regulates the
CC trafficking and gating properties of AMPA-selective glutamate receptors
CC (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the
CC cell membrane and synapses and modulates their gating properties by
CC slowing their rates of activation, deactivation and desensitization and
CC by mediating their resensitization. {ECO:0000256|RuleBase:RU363085}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363085}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
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DR RefSeq; XP_018093160.1; XM_018237671.2.
DR AlphaFoldDB; A0A1L8ENA8; -.
DR STRING; 8355.A0A1L8ENA8; -.
DR PaxDb; 8355-A0A1L8ENA8; -.
DR GeneID; 108702163; -.
DR KEGG; xla:108702163; -.
DR AGR; Xenbase:XB-GENE-6487840; -.
DR CTD; 108702163; -.
DR Xenbase; XB-GENE-6487840; cacng4.S.
DR OMA; LGEISMY; -.
DR OrthoDB; 2957055at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 108702163; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR005423; VDCC_g4su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR PANTHER; PTHR12107:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01603; VDCCGAMMA4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU363085};
KW Calcium channel {ECO:0000256|RuleBase:RU363085};
KW Calcium transport {ECO:0000256|RuleBase:RU363085};
KW Ion channel {ECO:0000256|RuleBase:RU363085};
KW Ion transport {ECO:0000256|RuleBase:RU363085};
KW Membrane {ECO:0000256|RuleBase:RU363085};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW Transport {ECO:0000256|RuleBase:RU363085};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU363085}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 139..162
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 182..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
SQ SEQUENCE 326 AA; 36369 MW; A5FC6215BD60A50D CRC64;
MSWCDRGVQM LLATMGAFAA FSLMSVAIGT DYWLYSRAHI CNGTNITLDE TQGQAKKTKG
DLTHSGLWRI CCIEGLYKGN CYRINHFPED NDYDHDSSEY LLRIVRASSV FPILSTILLL
LGGLCVGAGH LYSSRNNIIL SAGILFVAAG LSNIIGIIVY ISSNAGDPSD KKDEDKKNQY
NYGWSFYFGA LSFIVAETIG VLAVNIYIER NKDLRFRSKR ILKTSSLSPY GRMPSYRYRR
RRSRSSSFST EPSPSREMSP VSMKIAGTLP MGEISMYTLT REPLKITTAA SFNSDSDASF
LQVHNCFQKE LEGINISVVN RRTTPV
//
