ID A0A1L8END2_XENLA Unreviewed; 1936 AA.
AC A0A1L8END2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Myosin-1B {ECO:0000313|RefSeq:XP_041435042.1};
GN Name=LOC108702858 {ECO:0000313|RefSeq:XP_041435042.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041435042.1};
RN [1] {ECO:0000313|RefSeq:XP_041435042.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041435042.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041435042.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_018094083.1; XM_018238594.1.
DR RefSeq; XP_041435042.1; XM_041579108.1.
DR STRING; 8355.A0A1L8END2; -.
DR PaxDb; 8355-A0A1L8END2; -.
DR KEGG; xla:108702858; -.
DR OMA; TARSWAN; -.
DR OrthoDB; 2877572at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 108702858; Expressed in muscle tissue and 1 other cell type or tissue.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF78; MYOSIN-4; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT REGION 656..678
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1150..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1881..1911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1936 AA; 223589 MW; B4F77AEC0C9358EB CRC64;
MSSDAEMAVF GPAAQFLRKS EKERIEAQNK PFDAKSSVFV VEIKESYVKG VLQSKEGGKA
IVKTEGGQTV TVKDDQIFPM NPPKFDKIED MAMMTHLNEP SVLYNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYNPEVV VAYRGKKRQE APPHIFSISD NAYQSMLTDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA AAPDKKKEEV AKSKGTLEDQ IIQANPLLEA FGNAKTVRND
NSSRFGKFIR IHFGTTGKLS SADIETYLLE KSRVTFQLKA ERSYHIFYQI MSNKKPELID
MLLITTNPYD YPFVSQGEIS VASIDDTEEL MATDSAIDIL GFTADEKMTI YKLTGAVMHY
GNMKFKQKQR EEQAEPDGSE VADKAAYLMC LNSSDLLKAL CYPRVKVGNE YVTKGQTVQQ
VHNSVGALGK AVYEKMFLWM VTRINEMLDT KQPRQFFIGV LDIAGFEIFD YNSLEQLCIN
FTNEKLQQFF NHHMFVLEQE EYKKEGIEWT FIDFGMDLAA CIELIEKPMG IFSILEEECM
FPKATDTSFK NKLYDQHLGK SNNFQKPKPV KGKAEAHFSL VHYAGTVDYN ITGWLEKNKD
PLNDTVIGLY QKSSMKTLAY LFSSYAAGDA EGGGKKGGKK KGSSFQTVSA LFRENLNKLM
SNLRTTHPHF VRCIIPNETK TPGAMEHALV LHQLRCNGVL EGIRICRKGF PSRILYGDFK
QRYKILNASA IPEGQFIDSK KASEKLLGSI DVDHTQYRFG HTKVFFKAGL LGLLEEMRDD
RLAEVITRTQ ARCRGFLMRE EFKKMMERRE ALFTIQYNIR SFMNVKHWPW MKLYFKIKPL
LKSAESEKEM QNMKEEFAKT KEMLAKSEAK RKELEEKMVK VLQEKNDLQL QVQSESENLI
DAEERCDQLI KAKIQSEAKI KELNERLEDE EESNAELTAK KRKLEDECSE LKKDIDDLEL
TLAKVEKEKH ATENKVKNLT EEMAVLDETI VKLTKEKKAL QEAHQQTLDD LQAEEDKVNT
LTKAKAKLEQ QVDDLEGSLE QEKKLRMDLE RSKRKLEGDL KLAQETIMDL ENDRQQLDEK
LKKKEFEISQ FVSRIEDEQA LGAQLQKKIK ELQARIEELE EEIEAERTAR AKAEKQRSEF
SRELEEISER LEEAGGATSA QIEMNKKREA EFQKMRRDLE EATLQHEATA AALRKKQADS
VAELGEQIDN LQRVKQKLEK EKSELKMEID DLASNMEYVT KAKANFEKIC RTLEDQLSEL
KSKDEEHQRQ LNDITAQRAR LQTENGEYAR QLEEREALIS QLSRSKQAFT QQIEELKRQL
EEEIKAKNAL AHSLQSARHD CDLLREQYEE EQEAKAELQR SLSKANGEVA QWRTKYETDA
IQRTEELEDA KKKLAQRLQE AEEHIEAVNS KCASLEKTKL RLQNEVEDLM VDVERSNSAC
AALDKKQKNF DRILAEWKQK FEESQAELEA SQKESRSLST ELFKMKNSYE ESLDHLETTK
RENKNLQQEI SDLTEQISES NKLLHEVEKA KKLIEQEKTD IQSALEEAEA SLEHEEGKIL
RIQLELNQIK SEVDRKIAEK DEEMDQFKRN HIRVVESMQS SLDAEIRSRN DALRLKKKME
GDLNEMEIQL SHANRQAAES QKQLRNIQGL FKDVQIHLDD SLRAQEDLKE QLAMVERRAN
LMQAEIEEMR AALEQTERSR KVAEQELLDV SERVQLLHSQ NTSLINTKKK LETDMAQLQT
EVEEAIQEAR NAEDKAKKAI TDAAMMAEEL KKEQDTSAHL ERMKKNLDQT VKDLQHRLDE
AEQLAMKGGK KQIQKLEARV RELENEVESE QKRSTEAIKG VRKYERRVKE LTYQSEEDKK
NILRLQDLVD KLQMKVKAYK RQTEETEEQS NSNLTKYRKM QHELEEAEER ADIAESQVNK
LRAKTREVTK IVKSEE
//
