ID A0A1L8EPW1_XENLA Unreviewed; 507 AA.
AC A0A1L8EPW1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=NGFI-A binding protein 1 S homeolog isoform X1 {ECO:0000313|RefSeq:XP_018092581.1, ECO:0000313|RefSeq:XP_018092582.1};
GN Name=nab1.S {ECO:0000313|RefSeq:XP_018092581.1,
GN ECO:0000313|RefSeq:XP_018092582.1, ECO:0000313|RefSeq:XP_018092583.1,
GN ECO:0000313|Xenbase:XB-GENE-1194160};
GN Synonyms=nab1 {ECO:0000313|RefSeq:XP_018092581.1,
GN ECO:0000313|RefSeq:XP_018092582.1, ECO:0000313|RefSeq:XP_018092583.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018092581.1};
RN [1] {ECO:0000313|RefSeq:XP_018092581.1, ECO:0000313|RefSeq:XP_018092582.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018092581.1,
RC ECO:0000313|RefSeq:XP_018092582.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018092581.1,
RC ECO:0000313|RefSeq:XP_018092582.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBUNIT: Homomultimers may associate with EGR1 bound to DNA.
CC {ECO:0000256|ARBA:ARBA00011364}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NAB family. {ECO:0000256|ARBA:ARBA00008864}.
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DR RefSeq; XP_018092581.1; XM_018237092.2.
DR RefSeq; XP_018092582.1; XM_018237093.2.
DR RefSeq; XP_018092583.1; XM_018237094.2.
DR STRING; 8355.A0A1L8EPW1; -.
DR PaxDb; 8355-A0A1L8EPW1; -.
DR GeneID; 100137690; -.
DR AGR; Xenbase:XB-GENE-1194160; -.
DR CTD; 100137690; -.
DR Xenbase; XB-GENE-1194160; nab1.S.
DR OrthoDB; 4181992at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 100137690; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.20.120.2010; NAB conserved domain 2; 1.
DR InterPro; IPR006986; Nab1_C.
DR InterPro; IPR006989; NAB_co-repressor_dom.
DR InterPro; IPR039040; NAB_fam.
DR InterPro; IPR006988; Nab_N.
DR InterPro; IPR038398; NCD2_sf.
DR PANTHER; PTHR12623; NGFI-A BINDING PROTEIN; 1.
DR PANTHER; PTHR12623:SF9; NGFI-A-BINDING PROTEIN 1; 1.
DR Pfam; PF04902; Nab1; 1.
DR Pfam; PF04904; NCD1; 1.
DR Pfam; PF04905; NCD2; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..83
FT /note="Nab N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04904"
FT DOMAIN 191..317
FT /note="NAB co-repressor"
FT /evidence="ECO:0000259|Pfam:PF04905"
FT DOMAIN 323..506
FT /note="Nab1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04902"
FT REGION 140..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 57263 MW; 301825924A5D801B CRC64;
MASSLPRTVG ELQLYRILQR ANLLSYFDAF IQQGGDDVQQ LCEAGEEEFL EIMALVGMAS
KPLHVRRLQK ALRDWVTNPG IFNQPLTSLP VSSIPIYKLP ESSPSILGLN SSSYERNSNA
REPHLKIPKC AATTCVQSLG PGKSDGVGNS PLQNNSEGRH WQSHHTTESE HSLSPADLGS
PASPRDTTET LDASAALSVS ECVERMFPSL PKSDINEVRE MLKTNKKLSK MIGHIFEMGD
EEPHREEEIR KYSAIYGRFD SKRKDGKHLT LHELTVNEAA AQLCMKDIAL LTRRDELFTL
ARQISREVTY KYTYRTTKSK CEDQEELSPK RIKTEENFYD YQETLIALHQ QMESLKEQMT
VAKAKGEETA AHSLQAKLEK ILSKQMDLLR NSEYDRLPER CHSTGYYLKN SEDSSPNTIA
SDSSESQVEQ PLNLRTSNHH SQQLQQHMSD VEQHLGKQLC NELSGHYSSS ETNAQYSDSV
GILKDYSQSA LNNTERKVIK LEPEDTR
//
