ID   A0A1L8EQK4_XENLA        Unreviewed;       781 AA.
AC   A0A1L8EQK4;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=RNA exonuclease 5 {ECO:0000313|RefSeq:XP_018094683.1, ECO:0000313|RefSeq:XP_018094684.1};
GN   Name=rexo5.S {ECO:0000313|RefSeq:XP_018094683.1,
GN   ECO:0000313|RefSeq:XP_018094684.1, ECO:0000313|RefSeq:XP_018094685.1,
GN   ECO:0000313|Xenbase:XB-GENE-6488220};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018094684.1};
RN   [1] {ECO:0000313|RefSeq:XP_018094683.1, ECO:0000313|RefSeq:XP_018094684.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018094683.1,
RC   ECO:0000313|RefSeq:XP_018094684.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018094683.1,
RC   ECO:0000313|RefSeq:XP_018094684.1};
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
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DR   RefSeq; XP_018094683.1; XM_018239194.2.
DR   RefSeq; XP_018094684.1; XM_018239195.2.
DR   RefSeq; XP_018094685.1; XM_018239196.2.
DR   STRING; 8355.A0A1L8EQK4; -.
DR   PaxDb; 8355-A0A1L8EQK4; -.
DR   GeneID; 108703163; -.
DR   KEGG; xla:108703163; -.
DR   AGR; Xenbase:XB-GENE-6488220; -.
DR   CTD; 108703163; -.
DR   Xenbase; XB-GENE-6488220; rexo5.S.
DR   OMA; PHICIQY; -.
DR   OrthoDB; 5479236at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 108703163; Expressed in egg cell and 19 other cell types or tissues.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR047021; REXO1/3/4-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12801:SF115; RNA EXONUCLEASE 5; 1.
DR   PANTHER; PTHR12801; RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839,
KW   ECO:0000313|RefSeq:XP_018094683.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022839,
KW   ECO:0000313|RefSeq:XP_018094683.1};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022839,
KW   ECO:0000313|RefSeq:XP_018094683.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          533..607
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          628..702
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   781 AA;  87904 MW;  F8361D98EBF6BBB3 CRC64;
     MGEEPSLNTH KRRNCYIEDE TEPKKKRVKS EDQNINGSTL HKHKKSPRLS PALFRDNCII
     QHQQIHELLK YACLGKSCSS AQPSWCRIHH QKRLGSVVII VLHDLAQLHF YQFYLHFPYL
     RKLFKHRFSM PVPSSDFIAT LIGAEEKVTS GIKEQEFSSL HPLSSLPGPA DTAFSSGETG
     ETFKHDPVIL KYGNKRLGLT RYLLSQEEMR KNNYPLVGSP DSIDYVNSGC SREITDDSPL
     FGLDCEMCLT DKGSELTRIS LVDANGSCIM DELVKPDNII RDYMTRFSGI TRKLLLPVKM
     KLKDVQHKLK SLLPPNAVLV GHSLDNDLRA LQMIHPHVID TALLFAREYG RKFRLKFLAQ
     VVLGREIQTE DRMGHCPAED ARATLNLAQY FIHHGPEKVA QLQLHSILRS MNNPNGSLAA
     QEKTLQVKQN GSLLPLTTPI EQQSEEPHSL MESLYSDGKK ILYMARINGV KESVSSKLLE
     NIWCSSEEEV LKNACSLAQP ASISIVKFSP GDRYSQGTEE LHERSRSMFS NMMTVFAGPF
     EETFCLESVR RVFRTCGPIK SLKVLSQNYQ PYFCVEYSVL EAAQLAVETL DGGHINGCCI
     KVQRLVTEQT FNCEVLLKAM EEDAENKDVI YVSGFKKSLT EEILQQRFSH FSDLKAVFLP
     ASPLNGKAAK YCFLKFHHFQ SAAEAIDRIT GEGELRCRKA ITACHLHQWL QTVEPCGPQE
     RQVLPKEDGL SDIMESLDSN IMQVYENLPA NTLCLVLFSG TNSSSRSLPG FGLMGIKAAC
     G
//