ID   A0A1L8EUH9_XENLA        Unreviewed;       674 AA.
AC   A0A1L8EUH9;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|RuleBase:RU369081};
DE            EC=2.3.2.27 {ECO:0000256|RuleBase:RU369081};
DE   AltName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|RuleBase:RU369081};
GN   Name=rnf157.L {ECO:0000313|RefSeq:XP_018090839.1,
GN   ECO:0000313|Xenbase:XB-GENE-17331968};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018090839.1};
RN   [1] {ECO:0000313|RefSeq:XP_018090839.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018090839.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018090839.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: E3 ubiquitin ligase. {ECO:0000256|RuleBase:RU369081}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC         ECO:0000256|RuleBase:RU369081};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369081}.
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DR   RefSeq; XP_018090839.1; XM_018235350.2.
DR   AlphaFoldDB; A0A1L8EUH9; -.
DR   STRING; 8355.A0A1L8EUH9; -.
DR   MaxQB; A0A1L8EUH9; -.
DR   PaxDb; 8355-A0A1L8EUH9; -.
DR   GeneID; 108701126; -.
DR   KEGG; xla:108701126; -.
DR   AGR; Xenbase:XB-GENE-17331968; -.
DR   CTD; 108701126; -.
DR   Xenbase; XB-GENE-17331968; rnf157.L.
DR   OMA; EDSCPVH; -.
DR   OrthoDB; 383715at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 108701126; Expressed in camera-type eye and 19 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR   CDD; cd16817; mRING-HC-C3HC5_RNF157; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR045194; MGRN1/RNF157-like.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22996:SF1; E3 UBIQUITIN LIGASE RNF157; 1.
DR   PANTHER; PTHR22996; MAHOGUNIN; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|RuleBase:RU369081};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU369081};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transferase {ECO:0000256|RuleBase:RU369081};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU369081};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU369081};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU369081}.
SQ   SEQUENCE   674 AA;  73341 MW;  D5973061ECE3073D CRC64;
     MGALTSRQHA GVEEVDMPCS SLYRYPPKSG SYFGSHFIMG GEKFESSHPE GYLFGENSDL
     NFLGSRPVTF PYTAPSPQEP VKTLRSLINI RKDTLRLVRC TEELKSTGVE GSRPKVHYNV
     EFTFDTDAPV AITIYYQSTE EFQGGIASYL PKSSNLQSDT VHFKRGVSQQ FCFPSHTVDP
     AEWREEELTF DLDREVYPMV VHAVVEEGEE HLGHSHVLMA IFEKHADGSF CVKPLKQKQV
     VDGVSYLLQE IYGIENKYNS QDSKVAEDEV SDNSAECVVC LSDVRDTLIL PCRHLCLCNA
     CADTLRYQAS NCPICRLPFR ALLQIRAMRK VPGPHSPAGF SPIIAAPTSD SEEHTSEHVP
     PGYEVVSLLE ALNGPLTPSP SVPPLRALGE ARRPGALPSY GSDIHLRMHS PLQHLCGSQA
     LKLKKSISRS ISQNSSVLQE DEMEKSFSEA EIRTPRKKTS QLAEECGVTP ESDNLTLSSS
     GAIDQSSCTG TPLSPTITSP EDPLSSSLAQ SVMSMASSHS QQSQFSTDTV SSMSGSYTAG
     GMEEEEGGVT PSPPAAASGS PSMEGELSPA ESPEPHFVTV SAEEMDAEGN VTEEEFASPE
     EDDGQRTGRE CDNNNAAGVT LRDVLDNVRG SEGCLADVCY TSVPGQQRSN PYHGSDNCIS
     LQEDKQSQMD TELV
//