ID A0A1L8EV21_XENLA Unreviewed; 969 AA.
AC A0A1L8EV21;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ern1.L {ECO:0000313|RefSeq:XP_018091027.1,
GN ECO:0000313|Xenbase:XB-GENE-17339046};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018091027.1};
RN [1] {ECO:0000313|RefSeq:XP_018091027.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018091027.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018091027.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_018091027.1; XM_018235538.2.
DR AlphaFoldDB; A0A1L8EV21; -.
DR STRING; 8355.A0A1L8EV21; -.
DR PaxDb; 8355-A0A1L8EV21; -.
DR GeneID; 108701211; -.
DR AGR; Xenbase:XB-GENE-17339046; -.
DR CTD; 108701211; -.
DR Xenbase; XB-GENE-17339046; ern1.L.
DR OMA; NYWVERF; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 108701211; Expressed in pancreas and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_018091027.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 969 AA; 108834 MW; B2ED21535615FD4D CRC64;
MAPLAVLLLL FLCLTCGGSG STVSLPETLL FVSTLDGSLH AISKRTGSIR WTLKEDPVLQ
VPTHVTEPAF LPDPNDGSLY TLGSKNKEGL TKLPFTIPEL VQASPCRSSD GMLYMGKKQD
IWYVIDLVTG EKQQTLTSSF AESLCPSTSL LYLGRTEYTI TMYDTKNKVL HWNATYHDYA
ATLPDEGTEY KMSHFVSNGD GMVVTVDSES GDVLWIQNYA SPVVALYMWQ REGLRKVRHT
NVAVETLRYL TFMSGEVGRI TKWKYPFPKE TETKSKLMPT LYVGKYSTSL YASFSLVHEG
VTVVPRGRAI PLLDGPTTDG VTIEENGECE FTPSTDLKIP AGIKPKDKLS YWRNQWLLIG
HHEVPNSAPT KILENFPASL PRGQENVIET GAEKPRIPEE VLDMANEASE GLGTSYSQDL
SDISRPVPPK PEAPVDSMLK DMATIIFSTF LLAGWVAFVI TYPKTVQQQQ QLQHQQFQKQ
LEEKIQLLQM QNVPFQSPAD LSPDGDYLDI SGGQGEGSTV SSPNVSPKAS NHSVCSNISA
SEGASVISTE HEDADEDRHV AVGKISFNPR EVLGHGAEGT IVYRGHFDNR DVAVKRILPE
CFSFADREVQ LLRESDEHPN VIRYFCTERD RQFQYIAIEL CTATLQEYVE EKDFDRHGLE
PITLLEQTIS GLSYLHSLNI VHRDLKPHNI LISMPNAHGK VKAMISDFGL CKKLAVGRNS
FSRRSGVPGT EGWIAPEMLC EDSKENPTYT VDIFSAGCLF YYVISEGKHP FGKSLQRQAN
ILLGTYSLDC LDLGKHEDLV AHQLIEEMIN KDPQRRPSAP AVLKHPFFWS LDKQLQFFQD
VSDRIEKEAL DGPLVKQLER GGRSVVQMDW RQHITVPLQT DLRKFRSYKG NSVRDLLRAL
RNKKHHYREL PAEVQETLGG VPDDFVRYFT SRFPSLLLHT YLAMHMCSHE RPFQPYYHSD
PSTFCPDVA
//
