ID A0A1L8EX41_XENLA Unreviewed; 369 AA.
AC A0A1L8EX41;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Growth/differentiation factor 8 {ECO:0000256|ARBA:ARBA00023852, ECO:0000256|RuleBase:RU369049};
DE Short=GDF-8 {ECO:0000256|RuleBase:RU369049};
DE AltName: Full=Myostatin {ECO:0000256|ARBA:ARBA00031866, ECO:0000256|RuleBase:RU369049};
GN Name=LOC108701488 {ECO:0000313|RefSeq:XP_018091720.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018091720.1};
RN [1] {ECO:0000313|RefSeq:XP_018091720.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018091720.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018091720.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts specifically as a negative regulator of skeletal muscle
CC growth. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|RuleBase:RU369049}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369049}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_018091720.1; XM_018236231.2.
DR AlphaFoldDB; A0A1L8EX41; -.
DR STRING; 8355.A0A1L8EX41; -.
DR PaxDb; 8355-A0A1L8EX41; -.
DR GeneID; 108701488; -.
DR KEGG; xla:108701488; -.
DR OMA; AVRMIYM; -.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 108701488; Expressed in muscle tissue and 4 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF150; GROWTH_DIFFERENTIATION FACTOR 8; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU369049};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU369049};
KW Disulfide bond {ECO:0000256|RuleBase:RU369049};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369049};
KW Signal {ECO:0000256|RuleBase:RU369049}.
FT DOMAIN 257..369
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 369 AA; 41666 MW; 6FB1C4AF424FBD61 CRC64;
MINLRAWGCI YFCMLVVFNP VDLTDSNRAT DKDTLCSACT RRQNSKSTRL EAIKIQILSK
LQLEQAPNIS KDTIKYLLPK APPLQDLIDR YDVQKDESSA GHLEEDDYHV TAETIIIMPT
ESAISIDMKE KPICCFFKFS SKVQLTKISK AQLWIHLKPV QKPTTVVVQI SRLIKPLKDG
TRYIGIRSLK LEMNPGSGTW QSIDVKTVLQ NWLRQPESNL GIEIRAFDGN GQDLAVTSNE
DGLSPFMEVK IIDTPKRFRR DSGLDCDEYS TETMCCRYPL TVDFEAFGWD WVVAPKRYNA
NYCSGECGIE FLQKYPHGHV VNQANPKGPT GPCCSPTKMS SLNMLYFNDD AEVIQGKIPA
MVIDRCGCI
//
