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Database: UniProt
Entry: A0A1L8EZJ8_XENLA
LinkDB: A0A1L8EZJ8_XENLA
Original site: A0A1L8EZJ8_XENLA 
ID   A0A1L8EZJ8_XENLA        Unreviewed;      4607 AA.
AC   A0A1L8EZJ8;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   28-FEB-2018, entry version 8.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OCT64786.1};
GN   ORFNames=XELAEV_18041025mg {ECO:0000313|EMBL:OCT64786.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:OCT64786.1, ECO:0000313|Proteomes:UP000186698};
RN   [1] {ECO:0000313|Proteomes:UP000186698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J {ECO:0000313|Proteomes:UP000186698};
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J.,
RA   Quigley I., Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B.,
RA   Simakov O., Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T.,
RA   Watanabe M., Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S.,
RA   van Kruijsbergen I., Shu S., Carlson J., Kinoshita T., Ohta Y.,
RA   Mawaribuchi S., Jenkins J., Grimwood J., Schmutz J., Mitros T.,
RA   Mozaffari S.V., Suzuki Y., Haramoto Y., Yamamoto T.S., Takagi C.,
RA   Heald R., Miller K., Haudenschild C., Kitzman J., Nakayama T.,
RA   Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., Karimi K.,
RA   Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., Shendure J.,
RA   DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y.,
RA   Veenstra G.J., Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; CM004481; OCT64786.1; -; Genomic_DNA.
DR   Proteomes; UP000186698; Chromosome 8s.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186698};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3990   4013       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4215   4235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4362   4386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4407   4429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4488   4511       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       19     74       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       81    128       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      136    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      196    259       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      261    318       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      510    721       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      937   1133       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1179   1386       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3726   3761       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      384    404       {ECO:0000256|SAM:Coils}.
FT   COILED     1684   1704       {ECO:0000256|SAM:Coils}.
FT   COILED     2875   2895       {ECO:0000256|SAM:Coils}.
FT   COILED     3103   3123       {ECO:0000256|SAM:Coils}.
FT   COILED     3278   3298       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4607 AA;  522775 MW;  68C05924D773904C CRC64;
     MLANTMANAN EGASQGGGHR TLLYGHAILL RHSFSGMYLT CLTTSRSLTD KLAFDVGLQN
     TSTGEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSTERY LHLSISNGMS NIQVDASFMQ
     TLWNVHPTCS GSSVEEGFLL GGHVVRFFHG HDECLTIPST DSGEVQHRKV NYEAGGAGAR
     ARSLWRVEPL RISWSGSHIR WGQTFRLRHI TTGQYLTLTE DQGLVLQDRT KSDTKSSAFC
     FRASKEKLDT GSKRDIDGMG AAEIKYGDSI CFVQHVNSGL WLTYKSQDAK TARLGPLKRR
     AILHLEGHMD DGVCLQKCQH EESQAARIIR NTTALFSQFI SDLDSMTGNN WTGSTPTALP
     IEEVVQTLQD LISYFKPPDE ELEHEDKQNK LRSLKNRQNL FKEEGMLALV LNCIDRLNVY
     SGAAHFTELL GKKEGPSWKE ILNLLYELLA ALIRGNRSNC AQFSNNLDWL ISKLERLESS
     SGILEVLHCI LIESPEALNL IEKGHIRSII SLLDKHGRNH KVLDVLCSLC MCNGVAVRTN
     QNLICDNLLP RRDLLLQTRL VNDVTSMRPN IFLGVAEGSA QYKKWYFEMM IDQVDPFLTP
     EPTHLRVGWA STSGYAPYPG GGEGWGGNGV GDDLFSYGFD GLHLWSGRVP RAVASTNQHL
     LASDDVVSCC LDLGVPSISF RINGQPVQGM FENFNTVGLF FPVVSFSAGV KVRFILGGRH
     GEFKFLPPTG YAPCYEALLP KEKMRVEPVK EYKRDFDGVR DLLGTTHFLS QASFIPCPID
     TSQVVLPPHL EKIRDKLAEN IHELWGMNKI ELGWIYGKVR DDNKRQHPCL VEFSKLPDTE
     KNYNLQMSTE TLKTLLALGC LIVHSNQTAE ENLKKLKLPK NYMMSNGYKP APLDLSDLKL
     LPAQEVLVDK LAENAHNVWA KDRIKQGWTY GIQQDLKNKR NPRLVPYALL DERTKKSNRD
     SLREAVRTFI GYGYNIEPPD QEITDQMTER VGIDKIRFFR VEKTYAVESG KWYFEFEVVT
     GGDMRVGWAR PGCRPDLELG ADDQAFVFEG GRAQCWNMGS SYFGSSWQPG DVVGCMIDVD
     DKSMIFTLNG ELLITNQGSE LAFADFEIEN GFVPVCSIGL SQIGRMNLGK DASTFKYYTM
     CGLQEGFQPF AVNMNRDIVM WFSKRLPTFV NVPKEHPHIQ VTRIDGTVES PPCLKVTHKT
     FGTQNSNEDM IYCRLSMPVE FHSAFNTEEN FLKRNQIQEA SSHTTTTYYY SVRIFAGQDP
     SSVWVGWVTP DYHFYSKKFD LAKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDLSAGSE
     RSSRSSVDID IGCLVDLASG LLSFTANGKD LGTCYQVEPN TKLFPAVFLQ PTSTNLIQFE
     LGRLKNTMPL SAAIFKSEEK NPVPQCPPRL DVQTITPVLW SRMPNNFLKV ETERVSERHG
     WVVQCLEPLQ MMALHIPEEN RCIDILELSE QEDLMKFQNH TLQLYCAVCA LGNNRVSHAL
     CSHVDQSQLL YTIDNQYLPG LLRSGFYNLL ISMFLESAKE GKLMMNNEFI IPITDETRKI
     RLFPDESKRH GLPGVGRTTC LKSDLHFTMP CFVLTGEERQ QHGPEIPIDI LKTKAISMLT
     EAVQSSGEHI RDPVGGKVEF QFVPVLKLIA TLVIMGVFED EDVQQILLLI DPNVFGDNKE
     EETEEHEKEE VAQVEEKAVE AGEKATRDPT APTKGLLQTR LPESVKLQMC ELLHYFCDCE
     LKHRVESIVS FSDNFVSKLQ YNQKFRYNEL MLALNMSAAL TAKKTREFRS PPQEQINMLL
     NFQIQDDCPC PEEIRDELYQ FHEDLLMHSG IPLDEEEEEE EDTSMTGRLR TLLYKIKGRP
     KTEENDADEE EEKSPTTLKE LISHTMVRWA EEDHIQDPEL VRIMFTLLRR QYDSTGELLR
     AMRKTYTISA ASVEDTINLL ASLGQIRSLL SVRMGKEEEM LMIDGLGDIM NNKVFYQHPN
     LMRVLGMHET VMEVMVNVLG GDKSQQITFP KMVASCCRFL CYFCRISRQN QKAMFEHLGY
     LLENSSVGLA SPSMRGSTPL DVAAASVMDN NELALALQEP DLEKVVTYLA GCGLQSCPML
     IAKGYPDIGW NPIEGERYLS FLRFAVFVNA ESVEENASVV VKLLIRRPEC FGPSLRGEGG
     NGLLSAMQEA INISENPALD LPSQGYQREV VENEEEEEIV HMGNAIMSFY SALIDLLGRC
     APETHLIEAG KGEAIRIRSI LRSLVPTEDL VGIISIPLKL PAFNKDGSVF EPDMAASFCP
     DHKAPMVLFL DRVYGIKDQS VLLHLLEVAF LPDLRASASL DTASLSVTEM ALALNRYICS
     AVLPLLTRCA PLFSGTEHYA ALIDSTLHTI YRLSKGRSLT KAQRDTIEEC LLSICHHMRP
     SMLQQLLRRL VFDVPLLNEY CKMPLKLLTD HYELCWKYYC LPSGWGSYGL ASEEELHLTE
     KLFWGIFDSI SNKRYDAELF RMSMPCLSAI AGALPPDYVD TRIKATPEKQ MSVDAEGNFD
     PTPINTANLT LPEKLEYIVN KNAEHSHDKW AYDKIHSGWK YGLSLDENMK THPLLRPFKT
     LSEKEKEIYR WPLRESVKTM LTMGWSVERT KEGEALALHR ENEKMRSISQ SSQGNGYSPA
     PEDLGNVVLS RELQGMVEVM AENYHNIWAK KKKMELENKG GGSHPLLVPY DTLTAKEKAR
     DREKAQELFK FLQVNGYAIS RGLKDMELDA SSMEKRFAFK FLKKVLHYVD SAQEFIAHLE
     AVVSSGKSEK SPHEQEIKFF AKVLLPLVDQ YFQNHCLYFL SSPTKTLSSS GYASNKEKEM
     VASLFCKLAA LVRHRISLFG SDSATMVSCL HILAQTLDTR TVMKSGSELV KAGVRAFFEN
     AAEDLEKTLE NLKLGKFTHS RTQMKGVSQN INYTTVALLP ILTSIFEHVA RHQFGVDLLL
     DDVQVSCYRI LCSLYSLGTG KNIYVERSDT YYSVLGMPET VEQMCPDMPH LEGLMKEINE
     LAESGARYTE MPQVIEVVLP MLCNYLSYWW ERGTENVPEN AGPCCTQVTS EHLSVILGNI
     LKIINNNLGI DEASWMKRIA VYAQPIISKA QPDLLKSHFI PTLEKLKKKA IKIVQEEEQL
     KADSKADTQE AELLILDEFA VLCRDLYAFY PMLIRYVDNN RSNWLKKPDI DSDELFRMVA
     EVFILWCKSN NFKREEQNFV IQNEINNLAF LTGNNKNKMS KSGGQDQERK RIKRRGDLYS
     IQTSLIVAAL KKMLPIGQNM CTPGDQELIS LAKSRYNLRD TDDEVKEHLR NNLHLQEKSE
     DPAVKWQLNL YKDIRISDEQ SDSEKIVERV QKISAAIFHL EQVELPLRSK KAVWHKLLSK
     QRKRAVVACF RMVPLYNLPR HRSINLFLHG YQRFWIESEE NSFEEKLIED LAEKEMEKQK
     TLYQQARLHE RGAAEMVLQM ISASKGEMGP MVVETLKLGI AILNGGNTVV QQKMLDYLKE
     KKDAGFFQSL SGLMQSCSVL DLNAFERQNK AEGLGMVTEE GTLIVRERGE KVLQNDEFTC
     DLFRFLQLLC EGHNNDFQNF LRTQMGNTTT VNIIISTVDY LLRLQESISD FYWYYSGKEV
     IDESGQRNFS KSLAVTKQIF NSLTEYIQGP CIGNQQSLAH SRLWDAVVGF LHVFANMQMK
     LSQDSSQIEL LKELLDLLQD MVVMLLSLLE GNVVNGTIGK QMVDTLVESS SNVEMILKFF
     DMFLKLKDLT SSDAFKEYDP EGKGVISKKE FQKAMEGQKQ YAQSEIEFLL SCAEADENDM
     FNYVEFVDRF HEPAKDIGFN VAVLLTNLSE HMPNDSRLQC LLDPASSVLS YFSPYLGRIE
     IMGGAKRIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEQEKME LFVNFCEDTI
     FEMQLASQIS ESDAVERPEE EEEEESHHII EDGEEDEEAQ ALESSSAFIV ACTSLKNNTS
     NFLKMLTLKN IGKQLRKVKK MTLKELVKGF FSFFWMLFVG LFQFVFTIVW GIFQILWSTV
     FGGGLVEGAK NIKVTKILAD MPDPTQFGIH DDVLEAEKVD GTEHAASTEL ANLVKGDKGD
     LDIPDIFGTQ AKKEGSKHGP EIGLGDCSEA VTAESAPSLE NAVRKKKNAL AAELAKEHEE
     QTKAECEKAD LEDGEKKDKV KAEEQSELVE SKGNISKKKR RGQKKEESEA FMANFLAGLE
     IYQTKMLNYL ARNFYNLRFF ALFVAFAINF ILLFYKVPLV VFKREKEIAR NVEFEGLYIT
     EQPSEDDIKG QWDRLVINTP SFPNNYWDKF VKRKVINKYG DLYGADRIAE LLGLDKNALD
     FSPVKKTKPE EGSLVSWLSS IDTKYHIWKL GVVFTDNSFL YLAWYTTMSI LGHYNNFFFA
     AHLLDIAMGF KTLRTILSSV THNGKQLALT VGLLAVVVYL YTVVAFNFFR KFYNKSEDED
     DPDMKCDDMM TCYLFHMYVG VRAGGGIGDE IEDPAGDPYE MYRIVFDITF FFFVIVILLA
     IIQGLIIDAF GELRDQQEQV REDMETKCFI CGIGNDYFDT TPHGFETHTL QEHNLANYLF
     FLMYLINKDE TEHTGQESFV WKMYQERCWD FFPAGDCFRK QYEDQLS
//
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