UniProt: A0A1L8EZT5

Database: UniProt
Entry: A0A1L8EZT5_XENLA

LinkDB:  A0A1L8EZT5_XENLA 
Original site:  A0A1L8EZT5_XENLA

All links

Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (25)   
   InterPro (12)   
   Pfam (3)   
   PROSITE (7)   
   SMART (3)   
All databases (34)   

Download RDF

ID   A0A1L8EZT5_XENLA        Unreviewed;      1323 AA.
AC   A0A1L8EZT5;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   Name=LOC108699739 {ECO:0000313|RefSeq:XP_018087746.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018087746.1};
RN   [1] {ECO:0000313|RefSeq:XP_018087746.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018087746.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018087746.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171,
CC         ECO:0000256|RuleBase:RU000312};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_018087746.1; XM_018232257.2.
DR   STRING; 8355.A0A1L8EZT5; -.
DR   PaxDb; 8355-A0A1L8EZT5; -.
DR   GeneID; 108699739; -.
DR   KEGG; xla:108699739; -.
DR   OMA; REVMEMV; -.
DR   OrthoDB; 1614410at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 108699739; Expressed in egg cell and 7 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00112; LDLa; 1.
DR   CDD; cd06263; MAM; 1.
DR   CDD; cd05036; PTKc_ALK_LTK; 1.
DR   Gene3D; 2.60.120.200; -; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR000998; MAM_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   PANTHER; PTHR24416:SF294; LEUKOCYTE TYROSINE KINASE RECEPTOR; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF12810; Gly_rich; 1.
DR   Pfam; PF00629; MAM; 2.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00137; MAM; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS50060; MAM_2; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; Kinase {ECO:0000313|RefSeq:XP_018087746.1};
KW   Membrane {ECO:0000256|RuleBase:RU000312};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|RuleBase:RU000312,
KW   ECO:0000313|RefSeq:XP_018087746.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transferase {ECO:0000256|ARBA:ARBA00023137};
KW   Transmembrane {ECO:0000256|RuleBase:RU000312};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   BINDING         957
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT   DISULFID        249..267
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   1323 AA;  145492 MW;  35E71D7A0E3E1BE5 CRC64;
     MRCYSCAYAN IIDGTLILRP TEHIFLKVNV DLCGGLHAES IMSLNLPITS ESVSDDEKAE
     QLGQSCDFKI HCPWVSSKKR DGTPHWVQSI IGELEPEKQR ELLESQSSSR NKQDEILFLN
     TSRSLETCEV TWLLSPVLTG SSEMCQLELI LYSQEDAQIT AMVHNIKANL SLPLSLKEMT
     VNKRSNWKML SSEITGVNEP FRISLDYTHC DRAADYFIVL ESLTLKHCSA AGYQDSDVPT
     CIEETSFFCD NGDCMSHVKL CDFNWDCPTG EDEGALCEII LPPGSYCSFE DGTCGWTSYE
     GSDARWLFTD SAQMEDTSPT DLKFVKGHFL YLSVQSKYSD GNATTYSAMI PVVVPENDCQ
     LRFKFLISGI YNGSLGIYGL EEEKEFESSV KLWVKEGPLG DFWNSGTLQI PQFQNRFRLL
     VVAVWGWNTH AHIALDNVTF SADCFHAGRI EIGYENRGSM DDFEDTVTPL SEPFYTEENS
     ELELQFTTCG ASGPHGPTQT QCDNAYRNSN ISVVVCKDGP LRGLQMWKVP FTSTYQISAY
     GAAGGKGAKN HNNPAHGVFI SAIFPLHKDE TLFILVGQQG EDACPGKNEL TREICTGKSS
     VIEDNYDDQK KFSEWAGGGG GGGGASYVFK EVNGEFIPLL VAAGGGGKAY LEDTEDPLDL
     TQPERFENNT AVPGLNGMSA AAGGGGGWNE ITDLPVAGKS LVFGAEGGQS CYKAIIKLQW
     HTAGGFGGGG GPCTSGGGGG GYQGGNASEL DEIFSDGQYG VSFFHPSVKI FLHPLAAMEG
     HGEVQIKLFV NCSHCHTDNC KRDAISRNVV CLCDIGTVLA SDNITCIVPK WAIAEKQLPL
     SLIFAVLIAT VILGVIFACG SLSFVYHRKK KQLEGARVRL QSTEYKLSKI RSSIIMTDYN
     PNYCFAGKGA GLSELKEVPR KNITLLRALG HGAFGEVYEG MVVGISGDPN PLQVAIKTLP
     EICSEQDEMD FLMEALIISK FSHQNIVRCI GVSLQTLPRF ILLELMSGGD MKSFLRHNRP
     WLNKPSTLSM LDLLNMARDI ACGCKYLEDN HFIHRDIAAR NCLLMYSGTG RVAKIGDFGM
     ARDIYRASYY RKGGRAMLPV KWMPPEAFLE GVFTSKTDTW SFGVLLWEIF SLGYMPYPCK
     TNQEVLEFVT SGGRMDPPKN CPGPVYRIMT QCWQHTPGHR PNFSTILERI SYCTQDPDVI
     NTPLPIESGP APEDEGSTSI RPNNCNGINP MMSSPPLAPL LDTQSIEQKL GDAPQELLVE
     NLAGWNIKTP GLPTVAESTE GSWFQSNLNS TTEPNPQTTH KLKNKSKNLW NPTYGSWVME
     STC
//

DBGET integrated database retrieval system