ID   A0A1L8F1A4_XENLA        Unreviewed;      1104 AA.
AC   A0A1L8F1A4;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Hamartin isoform X5 {ECO:0000313|RefSeq:XP_018088124.1};
GN   Name=tsc1.S {ECO:0000313|RefSeq:XP_018088124.1,
GN   ECO:0000313|Xenbase:XB-GENE-6488161};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018088124.1};
RN   [1] {ECO:0000313|RefSeq:XP_018088124.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018088124.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018088124.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_018088124.1; XM_018232635.2.
DR   AlphaFoldDB; A0A1L8F1A4; -.
DR   STRING; 8355.A0A1L8F1A4; -.
DR   PaxDb; 8355-A0A1L8F1A4; -.
DR   GeneID; 108699932; -.
DR   AGR; Xenbase:XB-GENE-6488161; -.
DR   CTD; 108699932; -.
DR   Xenbase; XB-GENE-6488161; tsc1.S.
DR   OMA; RWRKMEV; -.
DR   OrthoDB; 4251017at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 108699932; Expressed in neurula embryo and 19 other cell types or tissues.
DR   InterPro; IPR007483; Hamartin.
DR   PANTHER; PTHR15154; HAMARTIN; 1.
DR   PANTHER; PTHR15154:SF2; HAMARTIN; 1.
DR   Pfam; PF04388; Hamartin; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT   REGION          281..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          990..1016
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          765..792
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          835..894
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        334..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1104 AA;  124372 MW;  0A3F868857D28493 CRC64;
     MAQQTTVWEH LYLLESSDLQ QLDQIHTLIR DHLIADRSPI LVNNLVDHYV ESGSEQAMLI
     LSMVQEPHDK HLLDKINEYL VKAASRLPTL TLLGHVIRRQ PSWKHKLSQA PVLQSLLKCL
     KVDNDVVVLT TGVLVLITVL PMIPQSGKQH LYEFFDIFGR LATWCLKNPG RVAEMCLVHL
     HASVYALFHR LYGMYPCNFV SFLRSHYSMK ENLETFEEIV KPMMEHVRIH PELVTGSKDH
     ELDPSRWKRL ETHDIVVECA KISLDPSEAS YEEGYSPLSN RLRQRQHDTT SSPYTEIRGS
     NASTPRTCTQ SAPPHTASIE LLQDSIWSPS TICGMTTPPN SPANVLVDAS HASSRPPSKV
     LYTPGGKATP LGTPATSPPP TSNSEECTPA SGASLTPHKK NESSDPGRPA TNRQLLSKGE
     KSTDESPKTQ KTVYLSELPD IISDFAADHN STEEAAICQE LSRITMPDPE PTVLRGGFDS
     PFSLRCDSQP GSQKKLASYS FGLIPEPSAT DKLHYSVSHD NSKQAFTPIE PPNGNENATD
     SGKPPSNNSL PSTADIFSPQ VQRNVSCFSL APYEHLFELA LPKTANLFLC NKTEELCRRG
     KGSLEEGEEG AFSISPAEVL DRLIQLGADA HTKELSNRLS LPSKAADWTH FGGSPPTDEI
     HVLRNQLVLL HNQLLYERFK RQQHAQRNRR LLRKVIKVTS LEEQNAAMKK QLKLQEVDMH
     SIKQSLFQEQ TRYRRLQEER DTVVTQLRSQ IRQLQHDRDL FYNQSQELQT KLEDCRTTIA
     DLRLEVKQAN NKVCHTELRL SQVSQKLSNS ESVQHQMEFL NRQLLVLGEV NELYVEQLQQ
     KQTNSTKEVE MLQTSFKKDL EKARLNVVQL SQRLECTQKR IVELEAQLAK KESLFQEQKK
     FLEHVKGKSR GQLQAAESRY LAQKRISQVF EVKILSLYNR LEKEGPLKSQ SEEKAETAEA
     AEERCDINIA SVYSPDVGIL EEVNGSEYNL PANRTSSSSS QSSSTLSTPE KGTNLQLSRR
     QLLEIPSSGH LTIGSYPNAK SFLGIRAREL FRNKSESHCD EESISSLSEI LKTELCQELI
     PETNAEGSPQ NQDCVRNLQI MDYD
//