ID   A0A1L8F1P3_XENLA        Unreviewed;      1370 AA.
AC   A0A1L8F1P3;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=IQ motif and SEC7 domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_018088221.1};
GN   Name=iqsec2.S {ECO:0000313|RefSeq:XP_018088221.1,
GN   ECO:0000313|Xenbase:XB-GENE-17330075};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018088221.1};
RN   [1] {ECO:0000313|RefSeq:XP_018088221.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018088221.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018088221.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   RefSeq; XP_018088221.1; XM_018232732.2.
DR   STRING; 8355.A0A1L8F1P3; -.
DR   PaxDb; 8355-A0A1L8F1P3; -.
DR   GeneID; 108699966; -.
DR   KEGG; xla:108699966; -.
DR   AGR; Xenbase:XB-GENE-17330075; -.
DR   CTD; 108699966; -.
DR   Xenbase; XB-GENE-17330075; iqsec2.S.
DR   OMA; CQTRRVQ; -.
DR   OrthoDB; 204547at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 108699966; Expressed in brain and 19 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ   SEQUENCE   1370 AA;  152956 MW;  83622C49BEBDF630 CRC64;
     MEGGAGSGSN PGGQESPNRA VEYLLELNNI IESQQKLLET QRRRIEELEV QLDRVSQENR
     ELREQQSVRV EREQHRAEYR GEAGGGGCGN YGHHHHHRGD NPQGYHGQPH QHHRAPHRGP
     TRSSSPGGGH STNNSPATTL QRKSDGENSR TMSVEGGDSL GSESGTIVDS PGQQPPYRGE
     VKSDHYDLPS PTRHPSHPGL QWSQRARLQP ASVSLRKQEE EENKRSKAFS DSYELSTDLQ
     DKKVEMLERK YGGYFLSRRA ARTIQTAFRQ YRMNKNFERL RSSASESRMS RRIILSNMRM
     QYSFEEYDKS HNVPYFQGKP VSLDEGVASC HGQGERGLQY GESCSGMDGD SINTSGEFCN
     EITDLEDSFS KQVKSLAESI DDALSCRSTH CSDPRDDKGS LEKGDSRDQH GDSTATSFSD
     VTLYMDEGVP VSPISLDRPP SSDHDTPQGT SSRQEYWATS SSREDSRENG SRRSTPCMEC
     RDFRMRGAHL PLLTIEPPSD SSVDLSDRSD RGSLNRQVVY EQENCSPHGT IKQAPHKGPI
     RSPNPHRHYH PEPPPPPTDN VGGNNGTSGG VGGGGMGGVR HMHHVKPELG ENSDGDNESL
     NSTTNSNETI NCSSGSSSHD SLREPTNTLC KQTYQRETRH SWDSPAFNND VVQRRQYRIG
     LNLFNKKPEK GIQYLIERGF LSDTPVGVAH FILERKGLSR QMIGEFLGNR QKQFNRDVLD
     CVVDEMDFSN MDLDDALRKF QAHIRVQGEA QKVERLIEAF SQRYCVCNSV LVRQFRNPDT
     IFILAFAIIL LNTDMYSPSV KPERKMKLDD FIKNLRGVDN GEDIPRDLLV GIYQRIQARE
     LRTNDDHVSQ VQAVERMIVG KKPVLSLPHR RLVCCCQLYE VPDPNRPQRM GVHQREVFLF
     NDLLVVTKIF QKKKILVTYS FRQSFPLVDM QMQLFQNSYY QNGIKLLSAV PGGERKVLII
     FNAPSLQDRL RVTSDLRESI AEVQEMEKYR VESELEKQKG VMRPNTSPGP GIKETVNGTL
     GRPSLDDTYA LGEGLKRSAL SSSLRDLSEA GKRGRRNSAG SLDSTIEGSI ISSPRPHQRI
     PPPAPAPPEE YKAPRPVSNS SSFLGSLFGT KRGKGPFQNV PPSPLPPHPQ TPPGMPEGQS
     KIQALHAQYF HNQGVLAQAP PPYHSQPPTT APPPQPHQPP PPPSHRYHVP PTSAQFTLQR
     PGQQKRQPPV GGTPMTPSSP HPQYTLHGRH QPNQPQSPLP MYGAVPQHAM SHTYPQHIHQ
     TQHTMQKQPP KHFVFSHHTS AMPSQPQRPS QYNQQHNQSP CSPISPIPPH PSYPPLPPPS
     PHTPHTPLTP HSPLLPTSPL PQHGSHHPMG SNTAPGNPKQ KPVNRISTVV
//