ID A0A1L8F2Y5_XENLA Unreviewed; 1224 AA.
AC A0A1L8F2Y5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=AF4/FMR2 family member 2 {ECO:0000313|RefSeq:XP_018088502.1};
GN Name=aff2.S {ECO:0000313|RefSeq:XP_018088502.1,
GN ECO:0000313|Xenbase:XB-GENE-17341245};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018088502.1};
RN [1] {ECO:0000313|RefSeq:XP_018088502.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018088502.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018088502.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_018088502.1; XM_018233013.2.
DR AlphaFoldDB; A0A1L8F2Y5; -.
DR STRING; 8355.A0A1L8F2Y5; -.
DR PaxDb; 8355-A0A1L8F2Y5; -.
DR GeneID; 108700123; -.
DR KEGG; xla:108700123; -.
DR AGR; Xenbase:XB-GENE-17341245; -.
DR CTD; 108700123; -.
DR Xenbase; XB-GENE-17341245; aff2.S.
DR OMA; CATFRGI; -.
DR OrthoDB; 4254515at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 108700123; Expressed in spleen.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF18; AF4_FMR2 FAMILY MEMBER 2; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 961..1223
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 93..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 136471 MW; 67819A383092926B CRC64;
MDLFDFFREW DLDQQCHYEQ DRSALKRKEW ERRTQEVQQD EDLFAAGFNL FGEPYKTNKG
DALANRVQNT LGNYDEMKDL LTNHNNQTHL VGIPKNSVPQ TPTPVEKNEQ NFFPDQRNRL
APCHQSSDQT SSSMPPPSSL APNTTLMHNH EGSRKSRVDW AHGGHTSSCT QSNQFNSQPS
RLKHNSSHDL LQIRYEDLYN CQSVIEELVP ATSSTHSRRH NHSKALSGEH SKSPIDSETL
GHGAVSPLPS TSLLAANNSV SSQNFPPGIH SKTSMVQQKP TAYVRPMDGQ DQVPNDSPEL
KPSTEIDDGY NNPLFGTLLE GKANVPVTKS KLPKLTIPQG NEVSLPNDPN CVEEILREMT
HSWPPPLTAI HTPCKAEQTK FAIPSKDSQH LTSGYNIQKR CDATNKTTAK SAPQKSMLED
DLKLSSDEED SEQANEKTKP RNIPVSGLPL QAVHGANLVN SSGGSGSSSE SESSSESDSD
SESSSSDIEC NEQARSATPE PEPPSTNTWQ LDKWLNKVNP HNKTIISSQN DVHSENNSET
QNNQQAEGKE KTELDNIISQ PDSKELLSPV REKSKLRATQ KNSDSKPLKQ KSPAPSEPVT
QRVAAKKQPK KVERTSSVEE NTWNKPNPTC STPKEKELRE TPEQPKTRTK TTVAKTAPRK
EQRTSIGSSS EKKRTKGTSK NVPKSREFVE TDSASESNTD QEEVLQVKIS TACSGPPNPN
KSKDCSSNIL SVSSLTSNSS GLSADQTHND LEEQFFSPLP VVQAELLSPL RDFEEVKSLW
VKIDLTLLSR VPGQESFDVL PLKNDPKETS FKYKQQTMNT TVERSSTKSR KKHKQSESSD
TQSNSKRQRL EDTAAPCFLP PCMSPIPSTR ITSTKETKRT TKKREEKAFP PLLSPLGDEP
SSMHTASTSM RHRKNSNMAA NAKISLEDDH SRSAGCVVEN IDHNHSESDV WSTETTLTNG
NIDYRRSKIT FDDTLHNADY YMQEAKRLKH KADALMEKFG KAVNYADAAL SFIECGNAME
RDPLEAKSPY TMYSETVELI RYAMRLKNFT GSAATEGEKK LAVLCYRCLS LLYLRMFKLK
KDHAMKYSRS LMEYFKNSSK SSQAPSPWGG NGKNTETPSP MSLSPSPVNT AGNSTGTGAS
SSTGTVSIPQ RIHHMAASHV NITNNVLRSY EHWDMADKLT KENKEFFQDL DTVMEPLTQH
SSMTYLVRYV RQGLHWLRIE SHLL
//
