GenomeNet

Database: UniProt
Entry: A0A1L8F3Z3_XENLA
LinkDB: A0A1L8F3Z3_XENLA
Original site: A0A1L8F3Z3_XENLA 
ID   A0A1L8F3Z3_XENLA        Unreviewed;      4957 AA.
AC   A0A1L8F3Z3;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   28-FEB-2018, entry version 8.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OCT66306.1};
GN   ORFNames=XELAEV_18042564mg {ECO:0000313|EMBL:OCT66306.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:OCT66306.1, ECO:0000313|Proteomes:UP000186698};
RN   [1] {ECO:0000313|Proteomes:UP000186698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J {ECO:0000313|Proteomes:UP000186698};
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J.,
RA   Quigley I., Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B.,
RA   Simakov O., Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T.,
RA   Watanabe M., Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S.,
RA   van Kruijsbergen I., Shu S., Carlson J., Kinoshita T., Ohta Y.,
RA   Mawaribuchi S., Jenkins J., Grimwood J., Schmutz J., Mitros T.,
RA   Mozaffari S.V., Suzuki Y., Haramoto Y., Yamamoto T.S., Takagi C.,
RA   Heald R., Miller K., Haudenschild C., Kitzman J., Nakayama T.,
RA   Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., Karimi K.,
RA   Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., Shendure J.,
RA   DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y.,
RA   Veenstra G.J., Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
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DR   EMBL; CM004481; OCT66306.1; -; Genomic_DNA.
DR   Proteomes; UP000186698; Chromosome 8s.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186698};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4237   4257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4489   4509       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4563   4584       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4697   4717       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4757   4779       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4838   4861       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       84    139       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      146    191       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      199    254       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      260    317       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      325    382       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      574    784       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1000   1196       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1333   1546       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      447    467       {ECO:0000256|SAM:Coils}.
FT   COILED     1840   1860       {ECO:0000256|SAM:Coils}.
FT   COILED     3344   3364       {ECO:0000256|SAM:Coils}.
FT   COILED     3650   3670       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4957 AA;  563255 MW;  A5DB4DA21453C854 CRC64;
     MQEDVVVLQC STTIRKEQLK MCMGAEGFGN RLCFLESTSN AQNVPPDLAI CCFVLKQSLS
     VRALQEMLAN TVDMGNESSQ GGGHRTLLYG HAILLRHLHS DMYLCCLTTS RSLTDKLAFD
     VGLQEDVTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLST ASGELQVDAS
     FMQTLWNMNP ITSVCELAEG YVTGGHVLRL FHGHMDECLT IASTDQGEEQ RRMPHYEAGA
     VCSHARSLWR LEPLRISWSG SHLKCGQSFR VRHVTTGRYL AKDDEKGLVV LDADRSNTKA
     TAFCFRASKE KLDVAPKKDV EGMGIAEIKY GESMCFVQHV SSGLWLTYGA LDAKVVRLGP
     LKRKAILHQE GHMDDALCLS RSQREESQAS RMIYSTAGLF NLFIKGLDSL SGKNKPSKPV
     TLPIDMVILT LQDLIGYFQH PEDELQHEEK QTKLRSLKNR QNLFQEEGII SLVLDCVDRL
     NVYSTAAHFS EFAGEEAGES WKEIVNLLYE LLAALIRGNR SNCALFSSNL DWVVSKLDRL
     EASSGILEVL YCVLIESPEV LNIIKENHIK SIISLLDKHG RNHKVLDVLC SLCVCNGVAV
     RSNQNLITEN LLPRRDLLLQ TRLVNYVTSM RPNVFLGTCE GSTQYKKWYY EMVVDHVEQY
     VTAEATHLRV GWAMTEGYSP YPGAGEGWGA NGVGDDLYSF GFDGLHLWSG RVCRAVASHN
     QHLLAADDVV SCCLDLTVPS ISFRINGHPV QGMFENFNLD GLFFPVVSFS AGIKIRFLLG
     GRHGDFKFLP PPGYTPAYEA LLPRDRMRIE PIKEYKHDYE NIRNLLGPTK SLSHTSFVPY
     PVDTVQIVLP PHLERIREKL AENVHELWAL TRIEQGWTYG TVRDDNKRLH PCLLDFHSLP
     EAERNYNLLM SGETLKTLLA LGCHVGMADE KAEENLKKVK LPKTYIMSNG YKPAPLDLSH
     VKLTPAQNTL VEKLAENGHN VWARDRVLQG WTYSIIQDIK NKRNPRLVPY SLLDEKTKKT
     NRDSLCEAVR TLIGYGYNIE PPDQESTAQG IIKACAKRMR IFRAEKSYAV KSGKWYFEFE
     AVTTGEMRVG WARPEVRPDM ELGADEFAYV FNGCRGQRWH IGSEPFGRNW LPGDVVGCMI
     DLTEMNIVFT LNGEMLISDS GSELAFKDIE IGDGFIPVCS LGMSQVGRLN LGQDVSSLRY
     FTICGLQEGF EPFAINMKRD ITTWFSKSLP QFVNAPTDHA HIEVARIDGT VDNPPCLKVT
     HKTFGSQNSN NDMQFFRLSL PVEFHETFKC TPGATPLTRT FTIPEDEVQE VDMDSEFEML
     KKAVSRKEAE ATNEKEATKE APKEQIKPEN EKDTASEKVK PKRGFLFKAR KPAFISPPPV
     VPTMPRLMKD VVPDDRDDPD IIMNTTTYYY SVRIFAGQEP TGVWIGWVTP DYHLYDMNFD
     LNKVRVATIT MGDDKGNIFN SIKRSNCYMV WGGEFGNNTQ QARVRKEDLV IGCLIDLATG
     LMTFTANGKE VNTFFQVEPN TKLFPAVFAS PQSQNMFQFE LGKLKNIMPI SAAMFRSENK
     NPVPQCPPRL EVQMLTPVVW SRMPNDFLNV ESERINERQG WMVECSENLM MMALHIPEEN
     RCIDILELSE RLDMLKFHYH TLKLYCSVCA LGNNRVAHAL CSHVDESQLL YTIESNHLSG
     LLRSGYYDLL ISMHLESEKR ARLTMNNEFI VPMTEETKSI TLFPKDNKKY GLPGVGMSTC
     LKPELHFSHT CFVSTRTDLY QLSPFIPLDI LKIKAINMLT EAVLDGGQHT RDPVGGSVEF
     QFVPVLKLIS TLLIMGVFED DDVRHILKMI EPNVFTEEEE EAEQEQAGEG EEEKEEAEEE
     DVEKGEDEQE TGEETEEQDK DQEDEGKAVE AGEEETKEAE EGLEEGLLQM KLPESVKLQM
     CNLLQYFCDR ELQHRVEAII AFSERHMDSL QTNQRLRYKE LMQAFTMSAA ETARRTREFR
     SPPQEQINML LNFRNLSEDE CPIPEDIQDE LTEFHTDLLA HCGVQMEGEE EEEHEDTSLH
     NRLLNLMEKL KNLRKKEEPE PEPEPEEKEE PKPSTLQELI SHTMVHWAQE SFIQSPELVR
     VMFSLLHRQY DGLGELIRAL PKAYTINAVS VEDTMNLLES LGQIRSLLIV QMGPEEENLM
     IQSIGNIMNN KVFYQHPNLM RALGMHETVM EVMVNVLGGG DSKEIRFPKM VTNCCRFLCY
     FCRISRQNQR AMFEHLSYLL QNSGIGLGMR GSTPLDVAAA SVIDNNELAL ALQEQDLEKV
     VSYLAGCGLQ SCPMLLSKGY PDIGWNPVGG ERYLDFQRFA VFVNGESVEE NANVVVRLLI
     RRPECFGPAL RGEGGNGLLA AIEEAIKISE DPARDGPTVK KDRRRELYGG EEVHEENRVH
     LGNAIMSFYS ALIDLLGRCA PEMHLIQAGK GEALRIRAIL RSLVPIEDLV GVISLPLQIP
     AFGKDGNIIE PKMSASFVPD HKSPMVLFLD RVYGIDNQDF LLQVLEVGFL PDMRATASLD
     TAAFSTTEMA LALNRYLCLA VLPLITKCAP LFAGTEHRAI MVDSMLHTIY RLSRGRSLTK
     AQRDVIEECL MALCRYLRPS MLQHLLRRLV FDVPILNEFA KMPLKLLTNH YERCWKYYCL
     PTGWANYGVT SEEELHLTRK LFWGIFESLA HKKFDAELSK ITMPCLCAIA GAIPPDYVDA
     SYSSKTEKKA SVDAEGNFDP KPVETLNVII PEKLDGFINK YAEYTHDKWA FEKIQNNWSY
     GETVDEEAKT HHMLRPYKTF SEKDKEIYRW PIKESLKAMI AWEWTVEKAR EGEEDKTEKK
     TKSRKISQTA QQTYDPTVQT FSPTPMDLTG ITLSRELQSM AEQLAENYHN TWGRKKKHEL
     EGKGGGTHPL LVPYDTLTAK EKARDREKAH ELLKFLQING YAVTRGLKDM ELDTSSIEKR
     FAYGFLQKLL KLMDTAQEFI AHLEAVVSSG RVEKSPHERE IKFFAKILLP LINQYFKNHC
     LYFLSTPAKV LGSGGHASNK EKEMIASLFC KMAALVRHRV SLFGTDAPAV VNCLHILGRS
     LDARTVMKSG PEIVKAGLRS FFEGASDDIE KMVENLKLGK VTQSSTQVKG VAQNINYTTV
     ALLPVLTSLF EHIAQHQFGD DVILDDLQVS CYRTLCSIYS LGTTKSPYVE KQRPALGECL
     ARLAAAMPVA FLEPSLNEYN VYSVYTTKSP RERAILGLPN SVEEMCPDIP DLETLMKEIS
     MLAESGARYT EMPHVIEVTL PMLCNYLPRW WERGPENIPD DSSPCCTSVT SEHLNTLLGN
     ILRIVVNNLG IDEASWMKRL AVFAQPIVSK AKPELLRSHF IPTMEKLKKR AGKVVAEEEQ
     LRMEAKGESE DSESLIRDEF SVLCRDLYAL YPLLIRYVDN NRANWLTEPN SDAEELFRMV
     GEVFIFWSKS HNFKREEQNF VVQNEINNMS FLTADSKSKM SKSGGSDQER TQKKRRGDRY
     SVQTSLIVAT LKKMLPIGLN MCSPTDQELI VLAKTRYSLK DTDEEVREFL QNNLHLQGKC
     DNSSMRWQMA LYNKMSGKAE DSNNPEKIVK RVQEVSAVLF HLELTEHPFK SKKAVWHKLL
     SKQRRRAVVA CFRMTPLYNL PRHRACNMFL EAYKQAWILG EAHNFEDRMI DDLAKSSEAE
     EEEEAEEEKK PDPLHQLILH FSRTALTEKS KLDKDYLYMA YADIMAKSCH VEEESEEAPE
     GEEEVELTFE EKEMEKQKLL YQQSRLHNRG AAEMVLQMIS ACKGEPGSMV SSTLKLGISI
     LNGGNNEVQQ KMLDYLKEKK EVGFFQSMQV LMQTCSVLDL NAFERQNKAE GLGMVTEDGT
     SEKVMADDLF TQDLFRLLQL LCEGHNNGMR DIHIVGPCTG NQQSLAHSRL WDAVVGFLHV
     FAHMMMKLAQ MPKNGGLRNG DSSQIGLLKE LLDLQKDMVV MLLSLLEGNI VNGTIARQMV
     DMLVESSSNV EMILKFFDMF LKLKDIVASD AFRDYVTDPR GLISKKDFQK AMDSQKQYST
     SEIQFLLSCS EADENEMINF EEFASRFQEP AKDIGFNLAV LLTNLSEHVP NDIRLQNFLE
     LADCIINYFK PYLGKIEIMG AGKRIERIYF EISETNKTQW EMPQVKESKR QFIFDVVNEG
     GESEKMELFV NFCEDTIFEM QIASQISEPE EEKADDDEDD IGEGSGEGEE AENGSPEEAS
     SAFGEFMSNV VNFFKMFTYK NLRRQYRKVK KMSFKEIILA IVSFLWTVFL GILHFIYSVC
     KGIFLLIWHA LFGGSLVEGA QKLTVTELLA SMPDPTQDEV HSDGPPVTVS DEEPDAGDVT
     DFVDISKEEV QKEGAEIFGL ELKKDGGQYR ISAPDAPGGL GDMGDTTPVE PPTPEGSPIL
     KRKFGDEEDA EGELEEHEEH EEHEVVPEVP EEEPEPETEK ADLENGEKSA EVQEDTAPEP
     EEPDDPEVKP KKKSARDKKP EAEEGGFQFW NELEIQRIKF MNYLSRNFYN LRFLALFLAF
     AINFILLFYK VSDAPRGEED FEGSGIEDEL SGMDDGGDEE DDEEEGPVYF VIEESTGYMQ
     PTLYMLSVIH TLIAFLCIIG YNCLKIPLVI FKREKELARK LEFDGVYITE QPEDDDIKGQ
     WDRLVLNTPS FPSNYWDKFV KRKVLDKYGD IYGRERIAEL LGMDLASLEI TSQNEKKPEP
     DKSLLSWFTS IDIKYQIWNF GVVFTDNTFL YLVWYWIMSI LGHYNNFFYA AHLLDIAMGV
     KTLRTILSSV THNGKQLMMT VGLLAVVVYL YTVVAFNFFR KFYNKSEDED EPDMKCDDMM
     TCYLFHMYVG VRAGGGIGDE IEDPAGDEYE LYRVVFDITF FFFVIVILLA IIQGLIIDAF
     GELRDQQEQV KEDMETKCFI CGIGSDYFDT TPHGFETHTF EEHNLANYMF FLMYLINKDE
     TEHTGQESYV WKMYQERCWD FFPAGDCFRK TYEDQLG
//
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