UniProt: A0A1L8F409

Database: UniProt
Entry: A0A1L8F409_XENLA

LinkDB:  A0A1L8F409_XENLA 
Original site:  A0A1L8F409_XENLA

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Ontology (2)   
   GO (2)   
Gene (3)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   XENBASE (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (6)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (1)   
   SMART (1)   
All databases (12)   

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ID   A0A1L8F409_XENLA        Unreviewed;       368 AA.
AC   A0A1L8F409;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit TIM50 {ECO:0000256|RuleBase:RU365079};
GN   Name=timm50.S {ECO:0000313|RefSeq:XP_018088859.1,
GN   ECO:0000313|Xenbase:XB-GENE-17341067};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018088859.1};
RN   [1] {ECO:0000313|RefSeq:XP_018088859.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018088859.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018088859.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane.
CC       {ECO:0000256|RuleBase:RU365079}.
CC   -!- SUBUNIT: Component of the TIM23 complex.
CC       {ECO:0000256|RuleBase:RU365079}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004434,
CC       ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU365079}.
CC   -!- SIMILARITY: Belongs to the TIM50 family.
CC       {ECO:0000256|ARBA:ARBA00006344, ECO:0000256|RuleBase:RU365079}.
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DR   RefSeq; XP_018088859.1; XM_018233370.2.
DR   AlphaFoldDB; A0A1L8F409; -.
DR   STRING; 8355.A0A1L8F409; -.
DR   PaxDb; 8355-A0A1L8F409; -.
DR   GeneID; 108700295; -.
DR   KEGG; xla:108700295; -.
DR   AGR; Xenbase:XB-GENE-17341067; -.
DR   CTD; 108700295; -.
DR   Xenbase; XB-GENE-17341067; timm50.S.
DR   OMA; WKSLHYY; -.
DR   OrthoDB; 11362at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 108700295; Expressed in oocyte and 19 other cell types or tissues.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd07521; HAD_FCP1-like; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR004274; FCP1_dom.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   PANTHER; PTHR12210; DULLARD PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR12210:SF3; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM50; 1.
DR   Pfam; PF03031; NIF; 1.
DR   SMART; SM00577; CPDc; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   PROSITE; PS50969; FCP1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU365079};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|RuleBase:RU365079};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365079};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946,
KW   ECO:0000256|RuleBase:RU365079};
KW   Translocation {ECO:0000256|ARBA:ARBA00023010,
KW   ECO:0000256|RuleBase:RU365079};
KW   Transmembrane {ECO:0000256|RuleBase:RU365079};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU365079};
KW   Transport {ECO:0000256|RuleBase:RU365079}.
FT   TRANSMEM        80..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365079"
SQ   SEQUENCE   368 AA;  41688 MW;  17929EDE1AC9344A CRC64;
     MAASLVPVCG RSVRLLRVLG HRAEPRFRAF SAEQGAEGGL TGSVLQEKLQ KRDTEASSDS
     SGSEEKQKKQ KENTANAKKV ILRVAGVLGV AGSGALVYIF GSNSVDEQGK EIPDEFDSDP
     PVVQQMKRTY KYFKDYRQMI IEPTSPQLLP DPLKEPYYQP PYTLVLELTD VLLHPEWSLS
     TGWRFKKRAG IDNLFKQLAP LYEIVIFTSE TGLTAFPLID SVDPHGFVSY RLFRDATRYT
     EGHHVKDISC LNRDPSHVVI VDCKREAFKL QPYNGLAIKK WDGNSEDRAL YDLTAFLKTI
     AVNGVDDVRT VLENYSLEDD PLEAFKRRQT QLEQEEQQRL SELSQLSKRQ TLSLGSFTSR
     LWPRSKQQ
//

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