ID   A0A1L8F443_XENLA        Unreviewed;      2003 AA.
AC   A0A1L8F443;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Uncharacterized protein plekhg2.S {ECO:0000313|RefSeq:XP_018088858.1};
GN   Name=plekhg2.S {ECO:0000313|RefSeq:XP_018088858.1,
GN   ECO:0000313|Xenbase:XB-GENE-17339117};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018088858.1};
RN   [1] {ECO:0000313|RefSeq:XP_018088858.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018088858.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018088858.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_018088858.1; XM_018233369.2.
DR   STRING; 8355.A0A1L8F443; -.
DR   PaxDb; 8355-A0A1L8F443; -.
DR   GeneID; 108700294; -.
DR   KEGG; xla:108700294; -.
DR   AGR; Xenbase:XB-GENE-17339117; -.
DR   CTD; 108700294; -.
DR   Xenbase; XB-GENE-17339117; plekhg2.S.
DR   OMA; NTGSCYT; -.
DR   OrthoDB; 5400510at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 108700294; Expressed in lung and 11 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR   PANTHER; PTHR45924; FI17866P1; 1.
DR   PANTHER; PTHR45924:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 2; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT   REGION          42..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1433..1461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1700..1738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1874..1904
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1704..1719
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1874..1891
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2003 AA;  223693 MW;  B6EEBC252871C443 CRC64;
     MRFVSKDVTL GNSQTGDFPA WELGAVQTGA RLHYKVTMPE GVSRGSSKRA CKQAAPRPTS
     VSSLSGIVDG MSGSCTSVNT VCSDSDRPVS LSSSTSSASL QDSHSSFGSS GALVSSQNTG
     SCYTQQNGSD ISLDLTPMAL LEGESERSAM DRTFPGYTYS PILRKARDPK IKLSHVDRVV
     LEILETEQAY VRDLKSIVED YLGCIIDCGH LPLKPEQVST LFCNIEDIYE FNSELLEDLE
     NCNSAHGIAE CFVMRSEDFD IYTLYCMNYP NSVSVLHECM KSEELVQFFR ERQASLSHSL
     PLETYLLKPV QRIMKYHLLL QELAKHFDKN APGYEVVEEA IITMTAVAWY INDMKRKQEH
     AVRLQEIQSQ LVNWQGPDLS AFGELVLEGT FRVQRMKKER AFFLFSKMLL IAKKRMDLFI
     YKMHIFCCNL SLTEHLKDGL SFRVSDLTIP KHQQVIQARN QEEKRHWVHS IKRLIVENHP
     ASIPQKAKQV LLENSFQYSP DVRLSPEPLK SPRLDELWAF SRSRRQSEPP QLMCSPERSK
     KLFPALSMDS GFQHRRGRRL SEPAKEIQAA FENSDLVPIK HAGSEGELFP SSGSLRSSDS
     VCTLESSILE VADEVYEEDN SFSLPEEALS GSLSITEEIL ELLNKRGLQA DLGIMEKSES
     LELTGSNTEP EEQLLNCEPE VKTTGIKTEN DQQLVKHGNV CHGSEVLSDS KDPLQYPTKA
     SVCQGHINSE SSEEEEPKGD PRESPLHMLE ELEQEETSGF CNTEIPEHEI VQDTVCLNEL
     ENPKLSGCVQ NESFNVHDTA ECQEPAKLEP LPEKNEKNLK TKRDSTLTQD DRLLIERIKN
     YYETAEAGVS YLSKEDSISY IPTGVVKDSI LRFNYILQQE VKKDKEKSLF GNTKCVDRGK
     QVISSRKPWS RLDKDSQPPV SLTEIRSPIT LPLEQETEYL SCAEIRKAWK EKEKPNPTES
     IATPRRETLC RKRMGTPEDV LVIMEECDVE VPLASKEIPL IGDARKEQKK QSMEEKVTKQ
     DNHHKMAIAS MIGDPGESKE ICCPAGLSLY ETEDNCLFEN SEKIINKVQL LAKMYSEKIG
     RMKTQRKNGD NKRQIVDQSK AIEETLPQVI EEKTGDKSVT EPHPYGHLLI HETLLHINCI
     QENSLLLAAA REVTGVLYRE DLNAMDNSTT QPLLREETFS ERLPDYEFQI PFTEEPVIEI
     MAKLSLESNE KQEVKLQTDE FRLAEVAMVQ SETSCSVLEP SQTCNEEASK AVTDGSLPDG
     LLPDGYTTKE KEKQVLTANL VEIPEKCNVM GLNVSVRNVQ HSFPVCHESE NSLRENPLLK
     ETEPHSTDQR NAYTENEDTT HVDFKESEAV SSPESPKIQT EEQAKYVSNG EQAKMNLENM
     KEEYKIADEN DLENWKIPKE TTKDTNPSVR GDHFPFKVDT VLPSSVQVCE NGTRSHSEDH
     VIPSSTNTPA KQHDTNTFNK NRGLSPSVFD VMQRLQLDSS FSVASRNNLN NSKKLNLATR
     SSSFKSKTST AQEFHSMDKT LLKPPKMQIG ESKTAPNILN PSALQKKLSS AMTLSKFLST
     SHAAPGYMKR RPLTMSKSSD SEINIQETLL KNHCPVPVIA KPLAGCSSHI NADSPETDIK
     TKSMKQSFQR DDRKEEHILG ELNPIEILSR NQGNQRSACS TNNCQELNLG DKERKPLDNP
     VCLSPGSAVL IAFPYPPPIK TTPTSTASEP NSRVQSPLPL RTRMCSPPPR SASKSFRMPS
     FSSSRSCSFT PLSFSQVEKS SSSSASSTPT CTSPSFMPNS PDPGYGFPFH PRKSWGNCFP
     SGRDRVVSPR SALNSPLGST DEENRFWSCS GSPPCLSPDT HSVPSGISSH ELTSIHWPDV
     HELRSKYGPL KVQKSTNHQN TVDTSSASLV KPIGYSPEGS KRSPKRVASL DSAIQHTHVI
     QRSKSTVGVG NGDKWDSSNE KEKANLKASY STTVNIQIGG SGRIASFTNA QVILTHPLLQ
     APESQTTRKI NINGSTLDPL PKS
//