ID A0A1L8F450_XENLA Unreviewed; 1939 AA.
AC A0A1L8F450;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Myosin-4 {ECO:0000313|RefSeq:XP_018088868.1};
GN Name=myh13.S {ECO:0000313|RefSeq:XP_018088868.1,
GN ECO:0000313|Xenbase:XB-GENE-11536245};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018088868.1};
RN [1] {ECO:0000313|RefSeq:XP_018088868.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018088868.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018088868.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_018088868.1; XM_018233379.2.
DR STRING; 8355.A0A1L8F450; -.
DR PaxDb; 8355-A0A1L8F450; -.
DR GeneID; 108700301; -.
DR KEGG; xla:108700301; -.
DR AGR; Xenbase:XB-GENE-11536245; -.
DR CTD; 108700301; -.
DR Xenbase; XB-GENE-11536245; myh13.S.
DR OMA; RDAIYVI; -.
DR OrthoDB; 2877572at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 108700301; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF77; MYOSIN-4 ISOFORM X1; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT REGION 660..682
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1153..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1939 AA; 223238 MW; 6FD44B74BE917A8D CRC64;
MASDAEMSVF GLAAPFLRKP EKERLEAQNK PFDAKNSCFV HDDKELYVKG TIASRDSSKV
TVNTVDDKTV TVKEEQVFPQ NPPKFDKIED MAMLTHLNEA SVLYNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYNPEVV AGYRGKKRQE APPHIFSISD NAYQFMLQDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA AIGDPGKKKE SINKLQGTLE DQIIQANPLL EAFGNAKTVR
NDNSSRFGKF IRIQFGTTGK LSSADIETYL LEKSRVTFQL SAERSYHIFY QILTNKKPEI
VEMLLLTTNP YDYSFISQGE ISVKSIDDEE ELMATDSAID ILGFNHDEKM GIYKMTGAVM
HKGNMKFKQK QREEQAEPDG TEVADKIGYL MGLNSADLLK ALCYPRVKVG NEFVTKGQTV
QQVYNSIGAL SKSVYEKLFL WMVTRINQQL DTKLPRQYFI GVLDIAGFEI FDLNSLEQLC
INFTNEKLQQ FFNHHMFVLE QEEYKKEGID WEFIDFGMDL AACIELIEKP MGIFSILEEE
CMFPKATDTS FKNKLYDQHL GKCKNFEKPK PAKGKAEAHF SLVHYAGTVD YNICGWLEKN
KDPLNETVVG LFQKSPVKLL SFLYSSYAGT DAAAEGGGKS GKKKKGSSFQ TVSALFRENL
NKLMTNLRST HPHFVRCLIP NETKTPGIME NHLIIHQLRC NGVLEGIRIC RKGFPSRILY
ADFKQRYKIL NANAIPEGQF IDSKKAAEKL LASIDVDHTQ YRFGHTKVFF KAGLLGVLEE
MRDDKLAEII TKTQALCRGF LMRVEFKKMV ERRDAIYVIQ YNIRAFMNVK HWPWMKLYFK
IKPLLKSAET EKEMANIKVE FDKTKEALAK SEARKKELEE KMVALLQEKN DLQLQCQSEF
ENLADSEERC EGLIKNKINL EAKIKELTER LEDEEESNAE LTAKKRKLED ECSELKKDID
DLELTLAKVE KEKHATENKV KNLTEEMSAL DDNISKIAKE KKALQEAHQQ TLDDLQAEED
KVNSLSKAKT KLEQQVDDLE GSLEQEKKLR LDLERAKRKL EGDLKLAQET IMDLENDKQQ
TDEKLKKKDF EMSQLQSRIE DEQTLASQLQ KKIKELQARI EEVEEEIEAE RAARAKVEKQ
RSDLSRELEE ISERLEEAGG ATSAQIEMNK KREAEFQKVR RDLEESTLQH EATAAALRKK
HADSVAELGE QLDNLQRVKQ KLEKEKSELK MEIDDLASNL ENVSKSKANI EKVSRMLEDQ
LSEIKSKDDE HQRIINDLTG QKARLQTENG EQSRQLEEKE SLISQLSRGK QAFTQQTEEL
KRQLEEESKA KNALAHALQS SRHDCDLLRE QYEEEQEAKA ELQRSLSKAN SEVAQWRTKY
ETDAIQRTEE LEEAKKKLAQ RLQEAEEQVE AVNSKCASLE KTKQRLQGEV EDLMVDVERA
NSVAAALDKK QRNFDKVLVE WKQKYEEGQS ELEAAQKEAR LLSTEIFKMK NAYEEALEHL
ETMKRENKNL QQEISDLTEQ MGETVKNIHE LEKAKKQVEQ ERGDLQAALE EAEGSLEHEE
AKILRIQLEL NQVKSEVDRK IAEKDEEIEQ LKRNTQRVID TMQSTLDSEI RSRNDALRLK
KKMEGDLNEM EIQLGHANRQ ATEAQKQLRN VQAQLKDTQL QLDDAIRAQD DMKEQLAVVE
RRTNLQQAEI EEMRSVLEQT ERSRKVAEQE LLDASERVQL LHSQNTSLLN TKKKLESDMV
QLQGEVEETV QEARNAEEKA KKAITDAAMM AEELKKEQDT SAHLERMKKN LEQTVKDLQH
RLDEAEQLAM KGGKKQLQKL EARVRELENE LDAEQKRGSD GIKGVRKYER RVKELTYQTE
EDRKNVLRLQ DLVDKLQLKV KAYKRQAEES EEQANAYMSR FRKVQHELEE AEERADIAES
QVNKLRAKSR DIGKKGENE
//
