ID   A0A1L8F6Z7_XENLA        Unreviewed;      1371 AA.
AC   A0A1L8F6Z7;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=FH2 domain-containing protein 1 {ECO:0000313|RefSeq:XP_018085215.1};
GN   Name=LOC108698325 {ECO:0000313|RefSeq:XP_018085215.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018085215.1};
RN   [1] {ECO:0000313|RefSeq:XP_018085215.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018085215.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018085215.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_018085215.1; XM_018229726.2.
DR   STRING; 8355.A0A1L8F6Z7; -.
DR   PaxDb; 8355-A0A1L8F6Z7; -.
DR   GeneID; 108698325; -.
DR   KEGG; xla:108698325; -.
DR   OMA; PHDGHNS; -.
DR   OrthoDB; 5310689at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 108698325; Expressed in ovary and 18 other cell types or tissues.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR027649; Inf2.
DR   PANTHER; PTHR46345:SF7; FH2 DOMAIN CONTAINING 3; 1.
DR   PANTHER; PTHR46345; INVERTED FORMIN-2; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51444; FH2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT   REGION          655..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          704..725
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          744..767
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          779..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          845..930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1032..1062
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1101..1179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1219..1278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          346..399
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        655..670
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        744..765
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        779..818
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        854..913
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1115..1129
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1145..1160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1251..1265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1371 AA;  154009 MW;  6C381F9E1067B85F CRC64;
     MLISMKMGTK DVSLCEEFPT QHNGLQAQEP SIPVKIPAPP PPPPPNLNNS MIPGSPILRF
     DTKQRSRLRN FNWEAIPPEK VKGKPSLWSS ELFHEDLQID TRRMEELFGK PEEDKKRNSL
     FVRRTMSLGD SHLNKVFLLD SRRSMNISIF LKQFKRSAEQ IVEDLRKGKA DEYSSEKLSE
     LVKQLPERDE IKRLQSFKGD KSRLSEADLF MLLLLELPSY ALRLEGLILK KDFHATLVSQ
     LSTARELKGA AEELLQCSEL HSILKLVLKA GNFMNAGGYA GNAVGFRISS LLKLAETKAN
     KPGMNLLHFV VMEVQSKNAG LLSFTDRLEH VSSASRLSEV GLLEEFNKLQ SRVTSMRQAL
     KASEQKDLRE QMDKFIEYAE EQLCEVQKEI KALQKARQQL VEFLCEEEVS FSLEECCKVF
     SCFCQKFQLA IKENQDRERE DKRRQQWEKE RLQKRLSVAT YSSSDNRPVG DDLEHTLERN
     LRSLTRSPSL RLCRMRSSGS FSPTSTIPEL FQKDKTQDGW DQKNANQMRE VSERLLKQQM
     EYKACKNVHI LNTTIHMNTE TTGQALATSQ TPATSQHQWL GKSGHTSSPL KEEPVSEILK
     PPIEHQELEK QATLPIFTAE TCVECQSKLE KPTKCMTLPK LMPNWLQPKT LDCRLESTNE
     SSSPPTHETA IQSDLLHPHS KPAIAMPEIN TMETLEKLRS QEIPGVSHTQ PQTESPRQCQ
     PKSDTNTLIN GIKYEKQNQT LIQDSQEPSC QPSLETVNTK ESLPSSPIEP LKLSLAQIVP
     ATQSQSHSES ASEACRQSPS NKEPTIFSQE NCESPNEAKS NALIPPELLN KRPLLWQNGM
     DTSIQFKPVP ANRRRSIPQS TTESPRLPVS RRQSVPQSAS ERTRQSTITL APDLSTTILS
     QPASKISSQS QHGKKTDSLK KTLSQSGLRE KNKSIVHPVM QQNSLHQTKP ELIGESHVQY
     ESDCPEPSCK QSELETRGQS AAHAELETAE EPIQLDTETP KQLLEQPLTR NVKQTQCQPM
     AKVLKQLIGK PTQKISKQSQ AQPGVQKSHP AAETANQSIA RSKPESIRYT LIRTSSVNTR
     TTVMESLSNK QQGKLTKALH STTQEKMTEP QNETSKTVKP KDPENKPLAK GQKSIHTIGK
     RETPNPCSKW KRELHSTPDR GGGGKVENIG AATGGNNAEH KREDNLRNVS IGRSGSPIAK
     TVKSSDLGLG MKRVSAQKDG APVHLQGPGG MKQTTSSPKL THKESRDIKS PNRTSSPSPG
     SGKMTHDKVT WSPKEKNDMA HVYSNDGAKV SERKYRSFLT SKSYIPAPQK SLQLPWHSLE
     PARESVWMPH VGPSRTNAVA RMAFRVIRQE FSTSIHRGLR SQHLDNLPIW R
//