ID A0A1L8F7B3_XENLA Unreviewed; 1691 AA.
AC A0A1L8F7B3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Collagen alpha-5(IV) chain isoform X3 {ECO:0000313|RefSeq:XP_018085325.1};
GN Name=col4a5.L {ECO:0000313|RefSeq:XP_018085325.1,
GN ECO:0000313|Xenbase:XB-GENE-17331745};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018085325.1};
RN [1] {ECO:0000313|RefSeq:XP_018085325.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018085325.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018085325.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR RefSeq; XP_018085325.1; XM_018229836.2.
DR STRING; 8355.A0A1L8F7B3; -.
DR PaxDb; 8355-A0A1L8F7B3; -.
DR GeneID; 108698395; -.
DR AGR; Xenbase:XB-GENE-17331745; -.
DR CTD; 108698395; -.
DR Xenbase; XB-GENE-17331745; col4a5.L.
DR OMA; SNNESCG; -.
DR OrthoDB; 2882192at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 108698395; Expressed in lung and 16 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1091; COLLAGEN ALPHA-2(IX) CHAIN-LIKE ISOFORM X1; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 13.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119,
KW ECO:0000313|RefSeq:XP_018085325.1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
SQ SEQUENCE 1691 AA; 161149 MW; 61D2FAA38CC46745 CRC64;
MRLGDWQRVP CVLAALLLVL CYWAHNAESA ACQGCTSASK CDCSGVKGEK GERGLPGLEG
HLGLPGFPGP EGPPGPRGPK GDGGIPGPFG PKGIRGPPGL PGFPGNPGQP GLPGQDGAPG
PSGIPGCNGT KGERGFPGSS GLSGTLGPPG PPGFPGAKGD PGESFPFAEG QKGDPGLPGL
PGLPGPTGPG GIQGPVGRPG PAGLPGTPGS PGPPGPKGNM GLNFQGSKGE KGEPGIQGLP
GPPGQLEQVE PPQTTIQKGE KGIPGDQGFP GERGPMGPPG PPGGAKGGKG ESGEPGKIGK
PGKDGKIGPP GGEGFRGDPG LPGSLGRNGE QGQKGDRGLP GPPGEVISRP GIGRVGPKGN
TGPPGITGSK GDRGFPGLQG PPGFPGTPGT SSVGPPGSPG LPGERGQKGD DGPPGISIPG
LPGSEGLTGS PGPPGLPGRP GPPSIPSAGI CQPGQPGPPG RPGDSGYAGE RGQKGDKGDT
CFNCIGNGIL GQKGDPGLPG LTGSPGLPGT SGQKGDEGIP GLNGLPGPPG FPGSSGPSGR
PGPKGEPGEV IGGIGIKGEK GDPGFPGPAG SPGLDGPNGR DGTTGTPGPK GEPGGFALKG
DRGLPGDLGL PGLPGDRGPM GPPGFGPSGP PGEKGIQGVS GRPGAPGIPG PKGAPGQTVM
ETGDPGPPGL PGIPGDAGSP GEPGVPGQPG IPGVSGAKGE PGVPGIGLPG AAGAKGFPGN
PGPSGAPGLA GRPGSEGIPG QPGLPGSKGD PGYGLPGPPG SQGPAGLKGS QGPKGDSGFP
GSPGLPGRGG FDGPVGPKGD PGQNGLPGTP GLPGVPGSGG QGPPGQPGLP GPAGPPGPSG
SPGIQGEKGD HGAPGFDMPG PPGDRGSPGF PGERGFTGPP GPPGGQGRDG LPGFSGAKGE
MGVMGPPGSV GPAGNPGNPG LSGPKGNDGN PGQPGLPGLP GREGEKGDRG PAGPPGIIDS
ANLQLKGIKG EPGFPGVPGL SGAKGAAGLP GNLGPPGQSG IPGSPGLPGP KGDSGFPGQP
GIGGAPGSKG SMGEMGLPGP PGAKGSFGQP GRPGSAGSPG FSGLKGEKGE PGISGAGIPG
SPGTKGEPGQ NGYPGSPGAK GNPGNPGLPG LPGTTGPKGD PGLPGFPGGP GSPGPKGADG
PTGNSGSPGP PGIRGESGRP GPQGSSGEKG QPGQDGIPGP SGLKGEPGLP GFGSPGLPGL
PGSSGPKGDA GFPGTPGNSG LPGFKGDQGF PGSPGPQGPP GQPGLPGPRT EGPKGDSGPV
GPPGRPGYPG PPGLEGARGP SGDGGFKGEK GNPGLAGQPG YPGSKGEPGA LGFPGDPGRP
GLNGMKGDQG VPGVPGLPGM KGPGGPPGLA GFQGDAGLPG AIGLPGPPGP KGEYREIKGA
SGLPGPPGRP GLNGPPGPPG PPGLTGPLGI PGDPGRDGLP GFEGQNGRKG DRGQAGQPGS
RGFNGPPGPD GLQGPPGPPG QGSVAHGFLI TRHSQSTDVP GCPLGTNIIY DGYSLLYVQG
NERAHGQDLG TAGSCLRRFS TMPFMFCNIN NVCNFASRND YSYWLSTPEP MPMSMDPLRG
RDIQPFISRC AVCEAPAMVI AVHSQTIQIP QCPQGWSSLW IGYSFMMHTS AGAEGSGQAL
ASPGSCLEEF RSAPFIECHG RGTCNYYANS YSFWLATVEM SEMFSKPQSE TLKAGDLRTR
VSRCQVCMKR T
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