ID A0A1L8F7H3_XENLA Unreviewed; 252 AA.
AC A0A1L8F7H3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN Name=tspan6.L {ECO:0000313|RefSeq:XP_018085383.1,
GN ECO:0000313|Xenbase:XB-GENE-17344739};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018085383.1};
RN [1] {ECO:0000313|RefSeq:XP_018085383.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018085383.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018085383.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC {ECO:0000256|ARBA:ARBA00006840, ECO:0000256|RuleBase:RU361218}.
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DR RefSeq; XP_018085383.1; XM_018229894.2.
DR AlphaFoldDB; A0A1L8F7H3; -.
DR STRING; 8355.A0A1L8F7H3; -.
DR PaxDb; 8355-A0A1L8F7H3; -.
DR GeneID; 108698419; -.
DR KEGG; xla:108698419; -.
DR AGR; Xenbase:XB-GENE-17344739; -.
DR CTD; 108698419; -.
DR Xenbase; XB-GENE-17344739; tspan6.L.
DR OMA; FLFRHEI; -.
DR OrthoDB; 2913577at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 108698419; Expressed in egg cell and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03161; TM4SF2_6_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR InterPro; IPR048232; TSN6/7_LEL.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF426; TETRASPANIN-32; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361218};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|RuleBase:RU361218};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361218}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 218..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
SQ SEQUENCE 252 AA; 27822 MW; C136875EFBB1ACE2 CRC64;
MASPSRRLQT KPVITCLKSV LLIYTFIFWI TGVILLTVGI WGKVGLDVYF SLLNENATNV
PYVLIGTGAV IILLGTFGCF ATCRASTWML KLYAMFLSII FLVELIAAIV GLVFRHEIKN
SFQQGYLQAL QQYNSTGDPR SQAVDTIQRT LQCCGVNSYN DWGQAPYYKT HGIPQSCCRV
PGNCTEADMK DMVKAGGKVF KQGCISLVTT VMESRMGVVA GISFGIACFQ LVGMFLACCL
SRYITNNQYE MV
//
