ID A0A1L8FA96_XENLA Unreviewed; 986 AA.
AC A0A1L8FA96;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 5 isoform X4 {ECO:0000313|RefSeq:XP_018086145.1};
GN Name=kcnh5.L {ECO:0000313|RefSeq:XP_018086145.1,
GN ECO:0000313|Xenbase:XB-GENE-17332810};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018086145.1};
RN [1] {ECO:0000313|RefSeq:XP_018086145.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018086145.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018086145.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_018086145.1; XM_018230656.2.
DR AlphaFoldDB; A0A1L8FA96; -.
DR STRING; 8355.A0A1L8FA96; -.
DR PaxDb; 8355-A0A1L8FA96; -.
DR GeneID; 108698819; -.
DR AGR; Xenbase:XB-GENE-17332810; -.
DR CTD; 108698819; -.
DR Xenbase; XB-GENE-17332810; kcnh5.L.
DR OMA; PMNKTET; -.
DR OrthoDB; 66005at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 108698819; Expressed in egg cell and 4 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF533; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 5; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01464; EAGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 781..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 111832 MW; 102EFCB7A4C90080 CRC64;
MPGGKRGLVA PQNTFLENIV RRSNESSFLL GNAQIVDWPV VYSNDGFCKL SGYHRADIMQ
KSSTCSFMYG ELTDKKTIEK VRQTFENYES NCFEILLYKK SRTPVWFYMQ IAPIRNEHEK
VVLFLCTFKD ITLFKQPIED ESTRGWTKFA RLTRALTNSR SVMQQLTPMN KAEVVHKHSR
LAEVLQLGSD ILPQYKQEAP KTPPHIILHY CTFKTTWDWV ILILTFYTAI MVPYNVSFKT
KQNNIAWLVL DSVVDVIFLV DIVLNFHTTF VGPGGEVISD PKLIRMNYLK TWFVIDLLSC
LPYDIINAFE NVDEGMSSLF SSLKVVRLLR LGRVARKLDH YLEYGAAVLV LLVCVFGLVA
HWLACIWYSI GDYEVIDEVT NTIKKDSWLY QLGLSIGTPY RYNASGSGQW EGGPSKDSLY
VSSLYFTMTS LTTIGFGNIA PTTDGEKIFS VAMMMVGSLL YATIFGNVTT IFQQMYANTN
RYHEVLNNVR DFLKLYQVPK GLSERVMDYI VSTWSMSKGI DTEKVLAICP KDMRADICVH
LNRKVFNEHP AFRLASDGCL RSLAVEFQTI HCAPGDLIYH AGESVDALCF VVSGSLEVIQ
DDEVVAILGK GDVFGDVFWK ETTLAHACAN VRALTYCDLH IIKREALLKV LEFYTAFANS
FSRNLTLTCN LRKRIIFRKI SDVKKEEEER QRQKNEVTLS IPVDHPVRKL FQKFKQQKEL
RNQGSSNTDL ERNQLQVEHC AMHNGAVLTG TSVVTVSQIT PIQTSLSYVR TNESMKQNNR
DAMELKPNSS SDTNSLKVTS PVRLKNGNGK GWLKLKNNMQ VQEEKKEDWN NVTKAESLGL
LSDDPKCTDP ETKVSKNSLR KTDSCDSGIT KSDLRLDKAG ETRSPLEHSP LQADAKHPFY
PIPEQALQTT LQEVKHELKD DIQSLSCRMT ALEQQVTEIL KLLTEKNKAP PSPPKIPTSP
LQIPCQDIFS VSRPVTPESE KEEIHV
//
