ID A0A1L8FAK2_XENLA Unreviewed; 923 AA.
AC A0A1L8FAK2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Sodium/calcium exchanger 3 isoform X3 {ECO:0000313|RefSeq:XP_018086593.1};
GN Name=slc8a3.L {ECO:0000313|RefSeq:XP_018086593.1,
GN ECO:0000313|Xenbase:XB-GENE-17342305};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018086593.1};
RN [1] {ECO:0000313|RefSeq:XP_018086593.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018086593.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018086593.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR RefSeq; XP_018086593.1; XM_018231104.2.
DR AlphaFoldDB; A0A1L8FAK2; -.
DR STRING; 8355.A0A1L8FAK2; -.
DR PaxDb; 8355-A0A1L8FAK2; -.
DR GeneID; 108699193; -.
DR AGR; Xenbase:XB-GENE-17342305; -.
DR CTD; 108699193; -.
DR Xenbase; XB-GENE-17342305; slc8a3.L.
DR OMA; VEMANYH; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 108699193; Expressed in muscle tissue and 18 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF7; SODIUM_CALCIUM EXCHANGER 3; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 384..484
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 513..613
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 923 AA; 102976 MW; A9A83D19DB0FE6AD CRC64;
MAQLKLQPLA SSFLHFGLVT FILFLQSLHV DAGASHNPEN TVQNDTCSGS YECKEGVILP
IWYPENPSMG DKIARVIVYF VAMIYMFLGV SIIADRFMAS IEVITSQERE IVIKKPNGET
STTTIRVWNE TVSNLTLMAL GSSAPEILLS LIEVCGHGFL AGDLGPSTIV GSAAFNMFII
MALCVYVIPD GEVRRIKHLR VFFVTAAWSI FAYIWLYMIL AVFSPGVVQV WEGLLTLFFF
PVCVVLAWVA DKRLLFYKYM HKKYRTDKHR AIMIETEADH PKGIEMDGKV MNSHFLDGNL
LNMDGKEVDE SRRDMIRILK ELKQKHPEKD LDQLVEMANY YALSHQQKSR AFYRIQATRM
MTGAGNILKK HAAEQSKRSS SLQDICIDES EEFVSKIYFD PCSYQCLENC GAVLLTVVRK
GGDISKTVFV DYKTEDGSAN AGADYEFTEG TLVFKSGETQ KEFSVGIIDD DIFEEDEHFF
IRLSNIRIGG APEPAEINSF SYPKAVLVSP YVASITILDD DHAGIFTFEC DIIRVSESIG
VMEVKVLRTS GARGTVIVPF RTVEGTAKGG GEDYEDSYGE LEFKNDETVQ TIQIKIFDDE
EYEKNKTFFI ELREPHLVDL SVQKALLLNH ADLAERKLSV EEEEAKRIAE MGKPILGEHP
KLEVVIEESY EFKSTVDKLI KKTNLALVVG THSWRDQFME AITVSAAGDE EDDDSGEERL
PSCFDYVMHF LTVFWKVLFA CVPPTEYLNG WACFVVSIII IGILTAIIGD LASHFGCTIG
LKDSVTAVVF VAFGTSVPDT FASKVAATQD VYADASIGNV TGSNAVNVFL GIGLAWSVAA
IYWASQGQEF HVSAGTLAFS VTLFTIFAFV CISVLLYRRR PHIGGELGGP KSYRLATTLL
FVTLWLLYIL FATLEAYCYI KGF
//
