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Database: UniProt
Entry: A0A1L8FAX4_XENLA
LinkDB: A0A1L8FAX4_XENLA
Original site: A0A1L8FAX4_XENLA 
ID   A0A1L8FAX4_XENLA        Unreviewed;      4870 AA.
AC   A0A1L8FAX4;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OCT68688.1};
GN   ORFNames=XELAEV_18039977mg {ECO:0000313|EMBL:OCT68688.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:OCT68688.1, ECO:0000313|Proteomes:UP000186698};
RN   [1] {ECO:0000313|Proteomes:UP000186698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J {ECO:0000313|Proteomes:UP000186698};
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J.,
RA   Quigley I., Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B.,
RA   Simakov O., Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T.,
RA   Watanabe M., Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S.,
RA   van Kruijsbergen I., Shu S., Carlson J., Kinoshita T., Ohta Y.,
RA   Mawaribuchi S., Jenkins J., Grimwood J., Schmutz J., Mitros T.,
RA   Mozaffari S.V., Suzuki Y., Haramoto Y., Yamamoto T.S., Takagi C.,
RA   Heald R., Miller K., Haudenschild C., Kitzman J., Nakayama T.,
RA   Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., Karimi K.,
RA   Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., Shendure J.,
RA   DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y.,
RA   Veenstra G.J., Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; CM004480; OCT68688.1; -; Genomic_DNA.
DR   RefSeq; XP_018086652.1; XM_018231163.1.
DR   GeneID; 108699223; -.
DR   KEGG; xla:108699223; -.
DR   KO; K04963; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000186698; Chromosome 8l.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186698};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4182   4206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4408   4428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4479   4498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4610   4628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4671   4692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4774       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    270       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      276    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      590    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1017   1213       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1259   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3919   3954       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      464    484       {ECO:0000256|SAM:Coils}.
FT   COILED     2961   2981       {ECO:0000256|SAM:Coils}.
FT   COILED     3226   3246       {ECO:0000256|SAM:Coils}.
FT   COILED     3401   3421       {ECO:0000256|SAM:Coils}.
FT   COILED     3588   3613       {ECO:0000256|SAM:Coils}.
FT   COILED     4313   4347       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4870 AA;  553251 MW;  CEA3903077CE3AE1 CRC64;
     MAEGGEVEDE IQFLRTDDEV VLQCVATIHK EQRKFCLAAE GLGNRLCFLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLANTMANGN EGASQGGGHR TLLYGHAILL RHSFSGMYLT
     CLTTSRSLTD KLAFDVGLRN TSTGEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSSERY
     LHLSISNGMS NIQVDASFMQ TLWNVHPTCS GSSVEEGFLL GGHVVRFFHG HDECLTIPST
     DSGEVQHRKV NYEAGGAGTR ARSLWRVEPL RISWSGSHIR WGQTFRLRHI TTGQYLTLTE
     DQGLVLQDRA KADTKSSAFC FRASKEKLDT GSKRDIDGMG AAEIKYGDSI CFVQHVNSGL
     WLTYKSQDAK TARLGPLKRR AILHQEGHMD DGVTLQKCQH EESQAARIIR NTTALFSHFI
     SDLDSVTGNN RTGSTPITLP IEEVVQTLQD LIAYFQPPEE ELEHEDKQNK LRSLKNRQNL
     FKEEGMLALV LNCIDRLNVY ISTAHFSELL GEKEGPAWKE ILNLLYELLA ALIRGNRSNC
     AQFSNNLDWL ISKLERLESS SGILEVLHCI LIESPEALNL IEKGHIRSII SLLDKHGRNH
     KVLDVLCSLC VCNGVAVRTN QNLICDNLLP RRDLLLQTRL VTDVTSMRPN IFLGVAEGSA
     QYKKWYFEMI IDQVDPFLTP EPTHLRVGWA STSGYAPYPG GGEGWGGNGV GDDLFSYGFD
     GLHLWSGRVP RAVASTNQHL LASDDVVSCC LDLGVPSISF RINGQPVQGM FENFNTEGLF
     FPVVSFSAGV KVRFLLGGRH GEFKFLPPAG YAPCYEALLP KEKMRVEPVK EYKRDFDGVR
     DYLGTTHFLS QASFIPCPID TSQIVLPPHL EKIRDKLAEN IHELWGMNKI ELGWIYGKVR
     DDNKRQHPCL VEFSKLPETE KNYNLQMSTE TLKTLLALGC LIVHSNQTAE ENLKKVKLPK
     NYMMSNGYKP APLDLSDVKL LPAQEVLVDK LAENAHNVWA KDRIKQGWTY GIQQDLKNKR
     NPRLVPYALL DERTKKSNRD SLREAVRTFI GYGYNIEPPD QEITDQMTER VSIDKIRFFR
     VEKTYAVESG KWYFEFEVVT GGDMRVGWAR PGCRPDLELG ADEQAFVFEG SRAQCWNMGS
     SYFGRSWQPG DVVGCMINLD DKSMIFTLNG ELLITNQGSE LAFADFEIEN GFVPVCSLGL
     SQIGRMNLGK DASTFKYYTM CGLQEGFQPY AVNMNRDVVM WFSKRLPTFV NVPKDHPHIE
     VTRIDGTVES PPCLKVTHKT FGTQNSNADM IYCRLSMPVE FHSAFNTEEN FLKRNQLQEA
     SSHTTTTYYY SVRIFAGQDP SSVWVGWVTP DYHFYREKFD LSKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDLSAGSQ RSSRSSVDID IGCLVDLATG LLSFTANGKD LGTCYQVEPN
     TKLFPAVFLQ PTSTNLIQFE LGRLKNTMPL SAAIFKSEEK NPVPQCPPRL DVQTITPVLW
     SRMPNNFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCIDILELSE QEDLMKFHYH
     TLKLYCAVCA LGNNRVSHAL CSHVDQSQLL YTIDNQYLPG LLRSGFYNLL ISMFLESAKE
     GKLMMNNEFI IPITDETRKI RLFPDESKRH GLPGVGRSTC LKSDLHFTVP CFVLTGEERQ
     QHGPEIPIDI LKTKAISMLT EAVQSSGEHI RDPVGGKVEF QFVPVLKLIA TLLIMGVFED
     EDVQQILLLI DPNVFGDNKE EETEEYEKEE VAQVEEKDVE AGEKAIRDPT SPTKGLLQTR
     LPESVKLQMC ELLHYFCDCE LKHRVESIVS FSDNFVSKLQ HNQKFRYNEL MQALNMSAAL
     TAKKTREFRS PPQEQINMLL NFRLHDDCPC PEEIRDELYE FHEDLLMHCG IPLDELEEEE
     EDTSWTGRLR TLLYKIKGRP KTEENDPDEE EEKSPTTLKE LISQTMVRWA QEDHIQDPEL
     VRIMFSLLRR QYDSIGELLR AMRRTYTISA ASVEDTINLL ASLGQIRSLL SVRMGKEEEM
     LMIDGLGDIM NNKVFYQHPN LMRVLGMHET VMEVMVNVLG GDKSQQIAFP KMVASCCRFL
     CYFCRISRQN QKAMFEHLGY LLENSSVGLA SPSMRGSTPL DVAAASVMDN NELALALQEP
     DLEKVVTYLA GCGLQSCLML IAKGYPDIGW NPIEGERYLS FLRFAVFVNG ESVEENASVV
     VKLLIRRPEC FGPSLRGEGG NGLLSAMQEA INISENPALD LPSHGYQREV VEEDEEEEIV
     HMGNAIMSFY SALIDLLGRC APETHLIEAG KGEAIRIRSI LRSLVPTEDL VGIISIPLKL
     PAFNKDGSVF EPDMAASFCP DHKAPMVLFL DRVYGIKDQS FLLHLLEVAF LPDLRASASL
     DTASLSVTEM ALALNRYICS AVLPLLTRCA PLFSGTEHYA ALIDSTLHTI YRLSKGRSLT
     KAQRDTIEEC LLSICHHMRP SMLQQLLRRL VFDVPLLNEY CKMPLKLLTN HYEQCWKYYC
     LPSGWGSYGL ASEEELHLTE KLFWGIFDSL SNKFLSLLQK YDAELFRMSM PCLSAIAGAL
     PPDYVDTRIK ATPEKQMSVD AEGNFDPKPI NTANLTLPEK LEYIVNKNAE HSHDKWAYDK
     IHSGWKYGMS LDENMKTHPL LRPYKTLSEK EKEIYRWPVR ESVKTMLSMG WSVERTKEGE
     ALALHRENEK MRSISQSSQG NGYNPAPQDL SNVVLSRELQ GMVEVMAENY HNIWAKKKKM
     ELESKGGGSH PLLVPYDTLT AKEKARDREK AQELFKFLQV NGYAISRGLK DMELDASSME
     KRFAFKFLKK VIHYVDSAQE FIAHLEAVVG SGKSEKSPHE QEIKFFAKVL LPLVDQYFKN
     HCLYFLSSPT KTLSSSGYAS NKEKEMVASL FCKLAALVRH RISLFGSDSA TMVSCLHILA
     QTLDTRTVMK SGSELVKAGV RAFFENAAED LEKTLENLKL GKFTHSRTQM KGVSQNINYT
     TVALLPILTS IFEHVARHQF GVDLLLDDVQ VSCYRILCSL YALGTGKNIY VERQRPALGE
     CLAALAGAIP VAFLEPSLNH NNPLTVFNTK SPRERAILGM PDTVEEMCPD MPHLEGLMKE
     INELAESGAR YTEMPHVIEV VLPMLCNYLS YWWERGTENV PENARPCCTL VTSEHLSVIL
     GNILKIINNN LGIDEASWMK RIAVYAQPII SKAQPDLLKS HFIPTLEKLK KKAIKIVLEE
     EQLKADSKAD TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRSNWLKK PDIDSDELFR
     MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGNTKS KMSKSGGQDQ ERKRIKRRGD
     LYSIQTSLIV AALKKMLPIG LNMCTPGDQE LISLAKSRYS LKDTDDEVKE HLRNNLHLQE
     KSEDPAVKWQ LNLYKDIRQS DEQSDSEKIV ERVQKISAAL FHLEQVEQPL RSKKAVWHKL
     LSKQRKRAVV ACFRMAPLYN LPRHKINNFF LSSYQRIWLE KVHENSDYDS LILVLTKPKK
     TDEEEEEETE KKPDPLHQII LHFSRNALTE RSKLEDDPLY TAYAAMMAKS CQNEEEDEEK
     EKTFEEKEME KQKTLYQQAR LHERGAAEMV LQMISASKGE MGPMVVETLK LGISVLNGGN
     TVVQQKMLDY LKEKKDAGFF QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTLIVRE
     RGEKVLQNDE FTRDLFRFLQ LLCEGHNNDF QNFLRTQMGN TTTVNIIIST VDYLLRLQES
     ISDFYWYYSG KEVIDESGQH NFSKSLAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV
     VGFLHVFANM QMKLSQDSSQ IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV
     ESSSNVEMIL KFFDMFLKLK DLTSSDAFKE YDPEGKGVIS KKEFQKAMEG QKQYAPSEIE
     FLLSCAEADE NDMFNYVEFV DRFHEPAKDI GFNVAVLLTN LSEHMPHDSR LQCLLEPASS
     VLSYFSPYLG RIEIMGGAKR IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE
     KMELFVNFCE DTIFEMQLAS QISDSDAVER PEEEEEEESH HIIEVGEEDE EAQSLESSSA
     FIVACTSLKN NTSNFLKMLT LKNIGKQLRK VKKMTLKELV KVFFSFFWML FVGLFQFVFT
     IVWGVFQILW STVFGGGLVE GAKNIKVTKI LGDMPDPTQF GIHDDVLEAE KVDANEHATS
     TELANLVKGD KGDVDMPDIF GIQGKKEGSK HSPEVGLGDF SEAVTTETAP SLENAVRKRK
     NALAAELAKE QEEQSKAESE KADLEDGEKK DKVKAEEQSE LVESKESISK KKRRGPKKEE
     PEAFMANFLA GLEIYQTKML NYLARNFYNL RFLALFVAFA INFILLFYKV TEEHSSEDSE
     DNETNLWDTF QEEEEDADEG AVYFVLQENT GYMAPTLRIL AVMHTIISFV CVIGYYCLKV
     PLVVFKREKE IARNVEFDGL YITEQPSEDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN
     KYGDLYGADR IAELLGLDKN ALDFSPVKKT KPEEGSLVSW LSSIDMKYHI WKLGVVFTDN
     SFLYLAWYTT MSILGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV
     VYLYTVVAFN FFRKFYNKSE DEDDPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD
     PYEMYRIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY
     FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC
     FRKQYEDQLG
//
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