ID A0A1L8FEG6_XENLA Unreviewed; 319 AA.
AC A0A1L8FEG6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=calcium homeostasis modulator 2 S homeolog isoform X1 {ECO:0000313|RefSeq:XP_018082427.1, ECO:0000313|RefSeq:XP_018082428.1};
GN Name=calhm2.S {ECO:0000313|RefSeq:XP_018082427.1,
GN ECO:0000313|RefSeq:XP_018082428.1, ECO:0000313|RefSeq:XP_018082429.1,
GN ECO:0000313|Xenbase:XB-GENE-6251477};
GN Synonyms=calhm2 {ECO:0000313|RefSeq:XP_018082427.1,
GN ECO:0000313|RefSeq:XP_018082428.1, ECO:0000313|RefSeq:XP_018082429.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018082428.1};
RN [1] {ECO:0000313|RefSeq:XP_018082427.1, ECO:0000313|RefSeq:XP_018082428.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018082427.1,
RC ECO:0000313|RefSeq:XP_018082428.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018082427.1,
RC ECO:0000313|RefSeq:XP_018082428.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CALHM family.
CC {ECO:0000256|ARBA:ARBA00008497}.
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DR RefSeq; XP_018082427.1; XM_018226938.2.
DR RefSeq; XP_018082428.1; XM_018226939.2.
DR RefSeq; XP_018082429.1; XM_018226940.2.
DR STRING; 8355.A0A1L8FEG6; -.
DR PaxDb; 8355-A0A1L8FEG6; -.
DR GeneID; 446391; -.
DR AGR; Xenbase:XB-GENE-6251477; -.
DR CTD; 446391; -.
DR Xenbase; XB-GENE-6251477; calhm2.S.
DR OMA; FAFHCPC; -.
DR OrthoDB; 2899675at2759; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 446391; Expressed in egg cell and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029569; CALHM.
DR PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1.
DR PANTHER; PTHR32261:SF3; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 2; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 319 AA; 35959 MW; 5EA421CE6B4B95F5 CRC64;
MASIITENLK FFSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP GRNYMYGLAA
IGVPALVLFL IGIMLNNHTW NLVAECQKRA LKNCSTPATF LLFGSILGRA LVAPVTWSVI
SLLRGEAYVC ARSEFLNPTA FLDFPSEYGP DSMARFSCPD TPKELIPFKD EVIRRLKYES
QFLGWILIAV IASAAFLLKC LQHCCTPLSF HQEDYWKQYR YAEKDLFNRT AEVHAKVLAA
NNVKQFFGFV ALDKDEKDIV SQYPVDEAQT SPQWQEITGV YLYRENKGFP LYSRLHKWAK
KVIGNGMDPD GREMALLAV
//
