ID A0A1L8FF05_XENLA Unreviewed; 144 AA.
AC A0A1L8FF05;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Anaphase-promoting complex subunit 16 {ECO:0000256|ARBA:ARBA00013930};
DE AltName: Full=Cyclosome subunit 16 {ECO:0000256|ARBA:ARBA00031333};
GN Name=anapc16.S {ECO:0000313|RefSeq:XP_018083058.1,
GN ECO:0000313|RefSeq:XP_018083059.1,
GN ECO:0000313|Xenbase:XB-GENE-17335189};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018083059.1};
RN [1] {ECO:0000313|RefSeq:XP_018083058.1, ECO:0000313|RefSeq:XP_018083059.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018083058.1,
RC ECO:0000313|RefSeq:XP_018083059.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018083058.1,
RC ECO:0000313|RefSeq:XP_018083059.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
CC {ECO:0000256|ARBA:ARBA00025025}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the APC16 family.
CC {ECO:0000256|ARBA:ARBA00007252}.
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DR RefSeq; XP_018083058.1; XM_018227569.2.
DR RefSeq; XP_018083059.1; XM_018227570.2.
DR STRING; 8355.A0A1L8FF05; -.
DR PaxDb; 8355-A0A1L8FF05; -.
DR GeneID; 108697486; -.
DR KEGG; xla:108697486; -.
DR AGR; Xenbase:XB-GENE-17335189; -.
DR CTD; 108697486; -.
DR Xenbase; XB-GENE-17335189; anapc16.S.
DR OMA; ADNWRYK; -.
DR OrthoDB; 5318708at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 108697486; Expressed in brain and 19 other cell types or tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR029641; APC16.
DR PANTHER; PTHR31564; ANAPHASE-PROMOTING COMPLEX SUBUNIT 16; 1.
DR PANTHER; PTHR31564:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 16; 1.
DR Pfam; PF17256; ANAPC16; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 144 AA; 15086 MW; 00566199BB7939C9 CRC64;
MSSVRNSLIT LTRATPGSAR ESGVPGAADF SRMAASSSSS SAGGVSGSSV TGSGFSVSDL
APPRKALFTC PKAAGEMLED GSERFLCESV FSYQVASTLK QVKHDQQVSR MEKLAGLVEE
LEADEWRYTP IEQLLGFTPS SGGK
//