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Database: UniProt
Entry: A0A1L8FG08_XENLA
LinkDB: A0A1L8FG08_XENLA
Original site: A0A1L8FG08_XENLA 
ID   A0A1L8FG08_XENLA        Unreviewed;       606 AA.
AC   A0A1L8FG08;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OCT70525.1};
GN   ORFNames=XELAEV_18037447mg {ECO:0000313|EMBL:OCT70525.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:OCT70525.1, ECO:0000313|Proteomes:UP000186698};
RN   [1] {ECO:0000313|Proteomes:UP000186698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J {ECO:0000313|Proteomes:UP000186698};
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J.,
RA   Quigley I., Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B.,
RA   Simakov O., Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T.,
RA   Watanabe M., Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S.,
RA   van Kruijsbergen I., Shu S., Carlson J., Kinoshita T., Ohta Y.,
RA   Mawaribuchi S., Jenkins J., Grimwood J., Schmutz J., Mitros T.,
RA   Mozaffari S.V., Suzuki Y., Haramoto Y., Yamamoto T.S., Takagi C.,
RA   Heald R., Miller K., Haudenschild C., Kitzman J., Nakayama T.,
RA   Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., Karimi K.,
RA   Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., Shendure J.,
RA   DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y.,
RA   Veenstra G.J., Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; CM004479; OCT70525.1; -; Genomic_DNA.
DR   Proteomes; UP000186698; Chromosome 7s.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000186698};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    265    287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    365       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      231    370       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      377    548       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     46       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      117    144       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS      7     30       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   606 AA;  69533 MW;  55FA5B33F151DBC8 CRC64;
     MVLPVPSSSS MHLQQDNSSC VQNNINDNRL NVDDPRVRRN SIPPARTPTA KHMLAYLPRP
     PTDTSRYGTF PQKPETMVVS TTSCDDYHQK TDIKTEHNGP KKGSIISSFI PLSANSIKES
     RQRRSITVDP TNSTAATQPV KHRPSVTINT EDLPRYQRAA KQEMPIQEVS NKWHPKHALS
     VPNIPMRSKN PTRSVVSAPV TTKSHRMRCK LMYDDRQLFN LTNRQARQRY VTKDGKCRVN
     LGRIDEKKRF LSDIFTTIVD LKFRCFIFVF MLCYIVTWVA FGVIYFVDAL LRDDVNHIGD
     PKWKPCIDNV DNFLSALLFS VETQRTIGYG SRMVSADCPE GVILIMAQSI LGSMIDALMV
     GCMFVKISRP KKRAETLIFS KKCVVSHRDE KLCLMFRIGD LRDSHMVDAK IRAKLIKSRQ
     TKEGEFIPLE QSEINLGYDT GEDRLFLVEP QIICHFINDH SPFWEMTAES LKREEFEIIV
     ILEGIVEATG MTCQAKTSYT EDEILWGHRF EPCMTLEKGA FRVDYSHFDK TFDVQTPWSS
     AKEMHEVKEM EQNDRSTLSF DWDNMLQTFL PDDSNTGSVD FIPHNQDKNY IAEEDCKESK
     SNDLDI
//
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