ID A0A1L8FG43_XENLA Unreviewed; 826 AA.
AC A0A1L8FG43;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=GDH/6PGL endoplasmic bifunctional protein isoform X1 {ECO:0000313|RefSeq:XP_018083335.1};
GN Name=h6pd.S {ECO:0000313|RefSeq:XP_018083335.1,
GN ECO:0000313|Xenbase:XB-GENE-6487871};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018083335.1};
RN [1] {ECO:0000313|RefSeq:XP_018083335.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018083335.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018083335.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC {ECO:0000256|ARBA:ARBA00004959}.
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DR RefSeq; XP_018083335.1; XM_018227846.1.
DR AlphaFoldDB; A0A1L8FG43; -.
DR STRING; 8355.A0A1L8FG43; -.
DR PaxDb; 8355-A0A1L8FG43; -.
DR GeneID; 108697628; -.
DR KEGG; xla:108697628; -.
DR AGR; Xenbase:XB-GENE-6487871; -.
DR CTD; 108697628; -.
DR Xenbase; XB-GENE-6487871; h6pd.S.
DR OMA; YCPQSGT; -.
DR OrthoDB; 989808at2759; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:InterPro.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR CDD; cd01400; 6PGL; 1.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR019796; G6P_DH_AS.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01198; pgl; 1.
DR PANTHER; PTHR23429:SF7; GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 67..250
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 255..558
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT DOMAIN 595..817
FT /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT /evidence="ECO:0000259|Pfam:PF01182"
FT BINDING 246
FT /ligand="substrate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10005"
SQ SEQUENCE 826 AA; 93837 MW; BEBE0CF3A105ABF7 CRC64;
MCDKKQLQGI RQLSNVYSHL PDDLQGPKRS LRQLGVNNML LKGLLIMLLL GTNFVDCTEH
KGHISVILVG ATGDLAKKYL WQGLFHLYLN EADTGHSFIF YGGALSPQEK GEGVIFDVLK
SLRCPGDVTP DRCALLKDQF LRLSRYRQLK TAENYTALNQ DIQNTMSEEG LHEAGRLFYL
SVPPFTYTDI ARSINATCRP LPGAWLRVVL EKPFGHDYAS AQQLATDLQL FFKEDEIYRI
DHYLGKQTVE QILPFRRQNR KHLDPIWNRE HVERVEIVLK ETVDAKARTS FYEEYGVIRD
VIQNHLTEIL TSVSMEVPLN YSKSYDALQA KLEVMNALQS LDHSSAVIGQ YQNYLAQVRE
ELEKNSNFFT NTQTFAGVLV QIDNTRWEGV PFILTSGKAL DERTAYVRVL FKDNSFCLQK
ETNGETDRTF CKRKQIIFHI GHGDLGFPAI LVSRGLFKPK FPSRHWQEAT ELPSLHLFGQ
PLTDYYVYRP VKEMDAYSLL ISNIFYGKKE TFVTTENLLS SWTFWTPLLE ILDRESPRVY
PGGRENGQLL DFVIENGGLQ FAAVEPLEIM GMEHKSSFAS IHSTFLGNSM VSNWAEQLIE
KLAQDIQLAA ESAVQKSGVF HLALSGGSTP LALFQRLTKH HHGFPWKRTH LWLVDERCVP
FTEPDSNFGN IEKYLLQHVR VPYINIHPMP VDRNQRICSE EDLGTEVYTK EISAHVSNSS
FDMVLLGLGS DGHTASIFPG AQDGIEGDKS VLFTESPGQP HRRMSLSLSL INKACKVAVL
VLGKGKHDIV TLISRAERNP MKWPIFGVNP TFGKLVWYID YDALLK
//