ID A0A1L8FK20_XENLA Unreviewed; 961 AA.
AC A0A1L8FK20;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=unc5b.L {ECO:0000313|RefSeq:XP_018079844.1,
GN ECO:0000313|Xenbase:XB-GENE-6046969};
GN Synonyms=p53rdl1 {ECO:0000313|RefSeq:XP_018079844.1}, unc5b
GN {ECO:0000313|RefSeq:XP_018079844.1}, unc5b-a
GN {ECO:0000313|RefSeq:XP_018079844.1}, unc5h2
GN {ECO:0000313|RefSeq:XP_018079844.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018079844.1};
RN [1] {ECO:0000313|RefSeq:XP_018079844.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018079844.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018079844.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR RefSeq; XP_018079844.1; XM_018224355.2.
DR AlphaFoldDB; A0A1L8FK20; -.
DR STRING; 8355.A0A1L8FK20; -.
DR PaxDb; 8355-A0A1L8FK20; -.
DR GeneID; 398393; -.
DR AGR; Xenbase:XB-GENE-6046969; -.
DR CTD; 398393; -.
DR Xenbase; XB-GENE-6046969; unc5b.L.
DR OMA; ASSDWIY; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 398393; Expressed in egg cell and 11 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF6; NETRIN RECEPTOR UNC5B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 31..961
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5035351890"
FT TRANSMEM 395..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
SQ SEQUENCE 961 AA; 107109 MW; D27F06F31ECD6581 CRC64;
MYLSRNPSGA ALAAILVALI LSCNFPSSTA GMYLKQKLPY LSSSTKAQGI EYSDVLPDSF
PSAPAESLPH FLLEPEDAYI VKNKPVELVC KANPATQIYF KCNGEWVNQN DHITKERVDD
VTGLVVREVQ IEVSRQQVEE LFGLEDYWCQ CVAWSSAGTT KSKRSYVRIA YLRKNFDQEP
LGKEVALEQE ALLQCRPPEG VPPAEVEWLK NEEIIDPTKD TNFLITIDHN LIIKQARLSD
TANYTCVSKN IVAKRRSTTA TVIVFVNGGW SSWTEWSPCN NRCGHGWQKR TRTCTNPAPL
NGGTMCEGQQ YQKFACNTMC PVDGGWTEWS KWSACSTECT HWRSRECNAP TPKNGGKDCS
GMLLDSKNCT DGLCMQNKRV LGETKSRLLE STGDVALYAG LVVAIFIVII LLMAVGIVVY
RRNCREFDTD ITDSSAALTG GFHPVNFKTS RHDNSQLIHP AMQPDLTANA GIYRGNMYAL
QDSADKIPMT NSPLLDPLPN LKIKVYNSST VGSSPGIHDG NNLLGTKPTG TYPSDNNIMN
ARNKNMSMQH LLTLPRDSSN SVTGTFGSLG GRLTFPNTGV SLLIPQGAIP QGKYYEMYLM
INKRENTVLP SEGTQTILSP IITCGPTGLL LCKPVILTVP HCADINTSDW ILQLKTQSHQ
GNWEEVVTLN EETLNTPCYC QLESHSCHTL LDQLGTYAFV GESYSRSAIK RLQLAIFAPM
LCTSLEYNLK VYCVEDTPDA LKEVLELEKT LGGYLVEEPK LLMFKDSYHN LRLSIHDIPH
SLWRSKLMAK YQEIPFYHIW SGSQRTLHCT FTLERYSLAA TELTCKICVR QVEGEGQIFQ
LHTLLEENVK SFDPFCSQAE NSVTTHLGPY AFKIPFSIRQ KICNSLDAPN SRGNDWRLLA
QKLCMDRYLN YFATKASPTG VILDLWEALH QDDGDLNTLA SALEEMGKSE MMLVMATDGD
C
//
