ID A0A1L8FRL8_XENLA Unreviewed; 235 AA.
AC A0A1L8FRL8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=znrf2.S {ECO:0000313|RefSeq:XP_018124809.1,
GN ECO:0000313|Xenbase:XB-GENE-17333023};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018124809.1};
RN [1] {ECO:0000313|RefSeq:XP_018124809.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018124809.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018124809.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR RefSeq; XP_018124809.1; XM_018269320.2.
DR AlphaFoldDB; A0A1L8FRL8; -.
DR STRING; 8355.A0A1L8FRL8; -.
DR PaxDb; 8355-A0A1L8FRL8; -.
DR GeneID; 108719979; -.
DR KEGG; xla:108719979; -.
DR AGR; Xenbase:XB-GENE-17333023; -.
DR CTD; 108719979; -.
DR Xenbase; XB-GENE-17333023; znrf2.S.
DR OMA; VAMRYHA; -.
DR OrthoDB; 5474929at2759; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR Bgee; 108719979; Expressed in oocyte and 19 other cell types or tissues.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd16695; mRING-CH-C4HC2H_ZNRF2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46661; E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN; 1.
DR PANTHER; PTHR46661:SF3; E3 UBIQUITIN-PROTEIN LIGASE ZNRF2; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 192..232
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 235 AA; 24708 MW; F12EC677356E9861 CRC64;
MRAEPTACVS GMGGRQSSSP AADGRTRAYS GSDIPSTTAR GPYRGPSGVA SSSSSPLARY
SYDSSGQETA GATGRGASGT DSVQPAALSS RSRSVGGIRS QAPLSIPGAA RDSGSSTPEE
GPRDRAHGGR ESRLMIGSLP AHLSPHLFGG FKCPVCSKFI PTDEMDLHLV MCLTKPRITY
NEDILTKDAG ECAICLEELQ QGDTIARLPC LCIYHKGCID EWFEVNRSCP EHPSD
//