ID A0A1L8FSZ5_XENLA Unreviewed; 318 AA.
AC A0A1L8FSZ5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Aquaporin-4 {ECO:0000256|ARBA:ARBA00040878};
GN Name=aqp4.S {ECO:0000313|RefSeq:NP_001342223.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:NP_001342223.1};
RN [1] {ECO:0000313|RefSeq:NP_001342223.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11726686;
RA Beier H., Grimm M.;
RT "Misreading of termination codons in eukaryotes by natural nonsense
RT suppressor tRNAs.";
RL Nucleic Acids Res. 29:4767-4782(2001).
RN [2] {ECO:0000313|RefSeq:NP_001342223.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25013167;
RA Loughran G., Chou M.Y., Ivanov I.P., Jungreis I., Kellis M., Kiran A.M.,
RA Baranov P.V., Atkins J.F.;
RT "Evidence of efficient stop codon readthrough in four mammalian genes.";
RL Nucleic Acids Res. 42:8928-8938(2014).
RN [3] {ECO:0000313|RefSeq:NP_001342223.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004415}. Cell projection
CC {ECO:0000256|ARBA:ARBA00004316}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR RefSeq; NP_001342223.1; NM_001355294.1.
DR AlphaFoldDB; A0A1L8FSZ5; -.
DR STRING; 8355.A0A1L8FSZ5; -.
DR PaxDb; 8355-A0A1L8FSZ5; -.
DR KEGG; xla:108695273; -.
DR OMA; PTAMFYW; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR NCBIfam; TIGR00861; MIP; 1.
DR PANTHER; PTHR19139; AQUAPORIN TRANSPORTER; 1.
DR PANTHER; PTHR19139:SF34; AQUAPORIN-4; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR02016; AQUAPORIN4.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000477};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
SQ SEQUENCE 318 AA; 34335 MW; 458DE9C82B994DCD CRC64;
MSDRPEASLR SKCGALCKCG KIMVACKGVW TQAFWKAVTG EFLAMLIFVL LSLGSTINWS
PKDNLQPADL VLISLCFGLS IATLVQCFGH ISGGHINPAV TVAMVCMRKI SLAKSVFYIV
AQCLGAIAGA GILYLVTPSD HAGNLGATLV NKKISSAHGL LVELIITFQL VFTICASCDP
KRKDITGSVA LAIGFSVAIG HLFAIPYTGA SMNPARSFGP AVIMNKWESH WVYWIGPVLG
AVIAGALYEY VYCPDPELKN HLKEVLNKAT QSSKRKYKEV EENKSQLESD DSLMKPTEVH
VIKEEKDKEP SGEVLSSV
//
