ID A0A1L8FTX8_XENLA Unreviewed; 833 AA.
AC A0A1L8FTX8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 3 {ECO:0000313|RefSeq:XP_041423958.1};
GN Name=kcnq3.S {ECO:0000313|RefSeq:XP_041423958.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041423958.1};
RN [1] {ECO:0000313|RefSeq:XP_041423958.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041423958.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041423958.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_041423958.1; XM_041568024.1.
DR AlphaFoldDB; A0A1L8FTX8; -.
DR STRING; 8355.A0A1L8FTX8; -.
DR PaxDb; 8355-A0A1L8FTX8; -.
DR KEGG; xla:108695451; -.
DR OMA; IRATSIM; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProt.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR020969; Ankyrin-G_BS.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR003948; K_chnl_volt-dep_KCNQ3.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735:SF11; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01462; KCNQ3CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..329
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 410..615
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 93632 MW; 00F561BBBDA6EE7A CRC64;
MGLKSRHSAG QVEKKAAHVG DGEQTSLGAG VDKDGTLLLV GPGKEDVKRN PQGIGLLAKT
PLSCSRPIKR NNAKYRRIQT LIYDALERPR GWALLYHAFV FLIVLGCLIL AVLTTFKEYE
DVSGDWLLLL ETFALVIFGV EFALRIWAAG CCCRYKGWRG RLKFARKPLC MLDIFVLVAS
IPVVAVGKSQ GNVLATSLRS LRFLQILRML RMDRRGGTWK LLGSAICSHS KELITAWYIG
FLTLILSSFL VYLVEKDVPE RNEKGELIEE EFETYADALW WGLITLATIG YGDKTPKTWE
GRLIAATFSL IGVSFFALPA GILGSGLALK VQEQHRQKHF EKRRKPAAEL IQAAWRFYAT
NLSRIDLIAT WRYYETTVQF PYFSQKWSLL DRVRLSNPRG TSPKAKTFSP LNIEGAEESP
SKEAKNIGLS NKERFRTALK MKAYAFWQSS EDAGAAGDPI ADSGYGTELL VEDLIPTIKA
AIHASRILQF LLHKKKFKET LRPYDVKDVI EQYSAGHLDM LSRIKYLQTR IDMVFAPGPL
STPKHKKSQK GTGGLGGGYG YSSQQSPRHD PYSVKVPEIE DQSMMGKFVK VERQVQDMEK
KLDFLVDMHM QHMDQLQVHI TEYYPLRETL AEDEGVGSRY SEVEGLIYNY TESCSHTSPY
HPLHQVSFNK TNQYGFFENY PRSFTAPLPF NGENCSRVAT PPSSYTERPT VLPIQTLIDT
RVDYQDSGKT SNPYLKEASP VQRRSFRDSD TPLSLLSVNH DELQRSPSGF SISQEKEDFS
FGNNGSNWMK EKRFLAEGET DTDTDPFTPS GPITLSSTGD GISDSAWTPS NPV
//
