ID A0A1L8FZC3_XENLA Unreviewed; 1130 AA.
AC A0A1L8FZC3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Extracellular sulfatase Sulf-1 isoform X1 {ECO:0000313|RefSeq:XP_018123564.1, ECO:0000313|RefSeq:XP_041422423.1};
GN Name=sulf1.L {ECO:0000313|RefSeq:XP_018123564.1,
GN ECO:0000313|RefSeq:XP_041422423.1,
GN ECO:0000313|Xenbase:XB-GENE-6488695};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018123564.1};
RN [1] {ECO:0000313|RefSeq:XP_018123564.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018123564.1,
RC ECO:0000313|RefSeq:XP_041422423.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018123564.1,
RC ECO:0000313|RefSeq:XP_041422423.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus,
CC Golgi stack {ECO:0000256|ARBA:ARBA00004348}.
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR RefSeq; XP_018123564.1; XM_018268075.2.
DR RefSeq; XP_041422423.1; XM_041566489.1.
DR STRING; 8355.A0A1L8FZC3; -.
DR PaxDb; 8355-A0A1L8FZC3; -.
DR GeneID; 108719292; -.
DR KEGG; xla:108719292; -.
DR AGR; Xenbase:XB-GENE-6488695; -.
DR CTD; 108719292; -.
DR Xenbase; XB-GENE-6488695; sulf1.L.
DR OMA; ECKRRKW; -.
DR OrthoDB; 1365192at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 108719292; Expressed in egg cell and 18 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd16147; G6S; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR024609; Extracellular_sulfatase_C.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR43108:SF1; EXTRACELLULAR SULFATASE SULF-1; 1.
DR PANTHER; PTHR43108; N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER; 1.
DR Pfam; PF12548; DUF3740; 2.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 2.
DR PROSITE; PS00523; SULFATASE_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1130
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041081215"
FT DOMAIN 43..373
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT DOMAIN 535..694
FT /note="Extracellular sulfatase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12548"
FT DOMAIN 697..755
FT /note="Extracellular sulfatase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12548"
FT REGION 561..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 658..685
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 561..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..602
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 130174 MW; FC7D7BE6807134B2 CRC64;
MKFLGFALVF ILLQMELPVG HGSSLKGSRV RGRIQPDRRN IRPNIILVLT DDQDVELGSL
QVMNKTRRIM EEGGASFINA FVTTPMCCPS RSSMLTGKYV HNHNIFTNNE NCSSPSWQAI
HEPRTFAVYL NNTGYRTAFF GKYLNEYNGS YIPPGWREWL GLVKNSRFYN YTMCRNGFKE
KHGFEYEKDY FTDLITNDSI NYFKLSKKMY PHRPIMMVIS HAAPHGPEDS APQFSEFFPN
ASQHITPSYN YAPNMDKHWI MQYTGAMLPI HMEFTNVLHR KRLQTLLSVD DSMEKLYNML
VDIGELENTY LIYTSDHGYH IGQFGLVKGK SMPYDFDIRV PFFVRGPNVE PGSVVPQMVL
NLDLAPTILD IAGLDTPPDM DGKSVLTLLD IERPGNRLRT NKKNKIWRDT FLVERGKFLR
KKEEPSKSTP QSNHLPKYER VKELCQQARY QTACEQPGQK WQCIEDMSGK LRIHKCKGSS
HTISLKKRTR SINSKGYGSK HKECVCGEAD YKPSRSQKKK QRLFMRTPGA KKFNPRFVHT
RHTRSLSVEF EGEIYDINLD DEEDHQSSQL RSITKRHYIS EEEVGGDEDD DDNGEDEEDE
EYMTTIPDND ELMLADGVIS ASQSASVRVT HKCYILANDT VHCERELYQS TKAWKDHKAY
IDKEIEALQD KIKNLREVRG HLKRRKPDEC DCSKPGFYKK EKGVKVQDRL KGRMHPFKDG
VQDVDNKFQI FKENRKKKKE RKEKKRQKKG EECSLPGLTC FTHDKNHWQT APFWNSGSFC
ACTSSNNNTY WCLRTINETH NFLFCEFATG FLEYFDMNTD PYQLTNAVHT VERGILNQLH
IQLMELRSCQ GHKQCNPRPK GLEAGDIYGT DGRANLPNFT EDVDWKGLED LYSVNETLYG
YRNNYRLSLD DWANYLKDVD RVFALLNGNS KQTRRNETLV TQPDGFSNAS RYEMTSAESE
EEFSGAAAED REPVTETNFS ALNMSIAVFN NEKKLETVND FPEQTDLNQP LWSNKNTERS
TAVAPDPYEV EFSGNGLTEM ESKNTFHLQT DIYLSTERQQ DRSLTSGDIF EDQVYLPIDS
KPVHQMALPA LQLDNSKNLE TTNNMSLLCY SEEISKDNVE GSALSPLLSD
//
