ID A0A1L8G1J3_XENLA Unreviewed; 435 AA.
AC A0A1L8G1J3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Forkhead box protein A2-B {ECO:0000313|RefSeq:XP_018120584.1};
GN Name=foxa2.S {ECO:0000313|Xenbase:XB-GENE-17336344};
GN Synonyms=LOC108717763 {ECO:0000313|RefSeq:XP_018120584.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018120584.1};
RN [1] {ECO:0000313|RefSeq:XP_018120584.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018120584.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018120584.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_018120584.1; XM_018265095.2.
DR AlphaFoldDB; A0A1L8G1J3; -.
DR STRING; 8355.A0A1L8G1J3; -.
DR PaxDb; 8355-A0A1L8G1J3; -.
DR GeneID; 108717763; -.
DR KEGG; xla:108717763; -.
DR CTD; 108717763; -.
DR Xenbase; XB-GENE-17336344; foxa2.S.
DR OMA; LGMNSYM; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 108717763; Expressed in pancreas and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR013638; Fork-head_N.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018533; Forkhead_box_C.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR PANTHER; PTHR11829:SF167; HEPATOCYTE NUCLEAR FACTOR 3-BETA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF08430; Forkhead_N; 1.
DR Pfam; PF09354; HNF_C; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DNA_BIND 149..243
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
SQ SEQUENCE 435 AA; 48060 MW; 496CA071E44E88F4 CRC64;
MLGAVKMEGH EATDWSSYYG EPEAYSSVGN MNAGLSMNPM NTYMSMSAMS TSANMTASSM
NMSYVNTGMS PSITGMSPGT GAMPGMGNGV ASMASHLSPS MSPMSAQATS MNALAPYTNI
NSMSPIYGQS NINRSRDPKT YRRSYTHAKP PYSYISLITM AIQQSPSKML TLSEVYQWIM
DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR
RQKRFKCDKK PSLREGGGKK LSEGASSVGS VGNSSSERSV GNESPHSSSS PCQEQKRSLV
DMKSSHGLSP EHATSPASQA QHLLSQHHSV LSHEAQSHLK PEHHYSFNHP FSINNLMSSE
QQHHHHHHHH NHQHHHKMDL KAYEQVMHYS GYGSPMAGSL AMSTVTNKSG LEPSPISSDT
SYYQGVYSRP IMNSS
//
