ID A0A1L8G2A8_XENLA Unreviewed; 517 AA.
AC A0A1L8G2A8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transmembrane protein 181 isoform X1 {ECO:0000313|RefSeq:XP_018120752.1};
GN Name=tmem181.S {ECO:0000313|RefSeq:XP_018120752.1,
GN ECO:0000313|Xenbase:XB-GENE-17331076};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018120752.1};
RN [1] {ECO:0000313|RefSeq:XP_018120752.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018120752.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018120752.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_018120752.1; XM_018265263.2.
DR AlphaFoldDB; A0A1L8G2A8; -.
DR STRING; 8355.A0A1L8G2A8; -.
DR PaxDb; 8355-A0A1L8G2A8; -.
DR GeneID; 108717858; -.
DR KEGG; xla:108717858; -.
DR AGR; Xenbase:XB-GENE-17331076; -.
DR CTD; 108717858; -.
DR Xenbase; XB-GENE-17331076; tmem181.S.
DR OMA; TEVATPF; -.
DR OrthoDB; 5478455at2759; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 108717858; Expressed in intestine and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR InterPro; IPR040416; TMEM181.
DR InterPro; IPR047843; WLS-like_TM.
DR PANTHER; PTHR31918; TRANSMEMBRANE PROTEIN 181; 1.
DR PANTHER; PTHR31918:SF1; TRANSMEMBRANE PROTEIN 181; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000313|RefSeq:XP_018120752.1};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 169..465
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
SQ SEQUENCE 517 AA; 60261 MW; 6A0AB3ACD8429267 CRC64;
MDPDYASFES SLCNEFKDFW KKISDAYNEL KEDLTPYRDD RFYRLAPMRL YTLSKRHFVL
VFVVFFICFG LTLFIGIAGP NVIQANSTGY EVVNKSKVEP FKLNSPVLST YNQQLWLTCR
IDLNKADDFS IQANFTMTVQ IHGVTPDATV TFISSPEHTR PRIIRCAQKC EEIIVVHLGY
LNYTQYKLLV SFENLKQLSI KSVTFTWKAY NPTFSQVEIW FRFVFVVLTF VVTCLFAHSL
RKFSMRDWGI EQKWMSLLLP LLLLYNDPFF PLTFLVNSWF PGMLDDLFQS IFLCALLLFW
LCVYHGIRVQ GERKCLTFYL PKLFIVGLLW LASVTLGIWQ TVNELHDPTY QYKVDTGNFQ
GMKIFFLIVA SLYILYLLFL IIRACTELRN MPYVDLRLKF LTALTFVVII ISIVILYLRF
GAQVLQDNFV AELTTHYENS AEFLSFYGLL NFYLYTLAFV YSPSKKALYE SQLKDNPAFS
MLNDSDDDVI YGSDYEEMPL QNGQATRAKY KAESDSD
//
