ID A0A1L8G6A7_XENLA Unreviewed; 536 AA.
AC A0A1L8G6A7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=suppressor of cytokine signaling 5 {ECO:0000313|RefSeq:XP_018118027.1, ECO:0000313|RefSeq:XP_041418425.1};
GN Name=socs5.L {ECO:0000313|RefSeq:XP_018118027.1,
GN ECO:0000313|RefSeq:XP_041418425.1, ECO:0000313|RefSeq:XP_041418426.1,
GN ECO:0000313|Xenbase:XB-GENE-865284};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041418425.1};
RN [1] {ECO:0000313|RefSeq:XP_018118027.1, ECO:0000313|RefSeq:XP_041418425.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018118027.1,
RC ECO:0000313|RefSeq:XP_041418425.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018118027.1,
RC ECO:0000313|RefSeq:XP_041418425.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_018118027.1; XM_018262538.2.
DR RefSeq; XP_041418425.1; XM_041562491.1.
DR RefSeq; XP_041418426.1; XM_041562492.1.
DR STRING; 8355.A0A1L8G6A7; -.
DR PaxDb; 8355-A0A1L8G6A7; -.
DR GeneID; 100381168; -.
DR KEGG; xla:100381168; -.
DR AGR; Xenbase:XB-GENE-865284; -.
DR CTD; 100381168; -.
DR Xenbase; XB-GENE-865284; socs5.L.
DR OMA; NRHATIP; -.
DR OrthoDB; 5362214at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 100381168; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR00678; PI3KINASEP85.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 381..476
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 471..520
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 63..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 61296 MW; 0D0FF5139E3D8A4D CRC64;
MEKVEKMWNT FKYRCQNLFS HDDDANQNDA VDVNANRCLR GMDKIENASD QSARLSIGPL
QQNITSELSP GPSGSSSRRS QNCVSEMPQV VEISVEKDND SGLSAGTRLA RRDSYTRHAP
WGAKKKHSCS TKTQNSFDPD KKICRTRSGL QRRERRHGTS SVHDMETMGS RAVGSHSLRQ
RLNETVGLCF PIRTYNRPSK PLFTNKRKIH LSELMLEKCP FPPGSDLAQK WHLIKQHTAP
VSPHPSFLET FDQSISTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAA AQVNPVYKLG
PKLAPGMADM SGDANAACQG GCESEEDTTT LCLQSRRQKQ RQFSGDSHTQ INKQGAWKVH
TQIDYIHCLV PDLIEIMSNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR
RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTVPLNRTF
PFSLQYICRA VICRSTTYDG IDFLPLPSML QDFLKEYHYK QKVRVRWLER EPVKSK
//
