ID A0A1L8G6C6_XENLA Unreviewed; 387 AA.
AC A0A1L8G6C6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=H2.0-like homeobox protein isoform X1 {ECO:0000313|RefSeq:XP_018118113.1};
GN Name=hlx.L {ECO:0000313|Xenbase:XB-GENE-6487236};
GN Synonyms=LOC108716468 {ECO:0000313|RefSeq:XP_018118113.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018118113.1};
RN [1] {ECO:0000313|RefSeq:XP_018118113.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018118113.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018118113.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the H2.0 homeobox family.
CC {ECO:0000256|ARBA:ARBA00038504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_018118113.1; XM_018262624.2.
DR AlphaFoldDB; A0A1L8G6C6; -.
DR PaxDb; 8355-A0A1L8G6C6; -.
DR GeneID; 108716468; -.
DR KEGG; xla:108716468; -.
DR CTD; 108716468; -.
DR Xenbase; XB-GENE-6487236; hlx.L.
DR OMA; EPMNEAS; -.
DR OrthoDB; 2911948at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 108716468; Expressed in spleen and 18 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR46808; H2.0-LIKE HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR46808:SF1; H2.0-LIKE HOMEOBOX PROTEIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DNA_BIND 236..295
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 387 AA; 42325 MW; 600E9D5D2620B28A CRC64;
MYATGLAPFY ASSHLNLWPA YCTGAAASGA VGFAALDTAK KPSFCIADIL HAGDPDSPPC
SSALTVGVMH PAQYQSAAGS PLRPTPVTPE SGFHHRLSPL PHYQPHRALS LCTNNSGRAR
MHGSSLPAPS SKDLKFGIDR ILSAEFDPKV KEGNTLRDLT SIISTGQQSG LLGQHMQSPA
GHFFAPLEPL GEASSLLGQL NSSQRSSAQQ QFQDTFPGPY AVLTKDTMPQ TYKRKRSWSR
AVFSNLQRKG LEKRFEVQKY VTKPDRKQLA AMLGLTDAQV KVWFQNRRMK WRHSKEAQAQ
KDKEKEEEAE KPEAPCSGEV HMDRSISPYR SEGESESSEC ESLDMMPSDN ERTETPSEPQ
PTSVIKSSPQ HCAPLSEAPT PPSPPLQ
//
