ID A0A1L8G6D5_XENLA Unreviewed; 555 AA.
AC A0A1L8G6D5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
DE EC=2.3.2.27 {ECO:0000256|PIRNR:PIRNR015614};
GN Name=traf5.L {ECO:0000313|RefSeq:XP_018118064.1,
GN ECO:0000313|Xenbase:XB-GENE-6486947};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018118064.1};
RN [1] {ECO:0000313|RefSeq:XP_018118064.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018118064.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018118064.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|PIRNR:PIRNR015614};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR RefSeq; XP_018118064.1; XM_018262575.2.
DR AlphaFoldDB; A0A1L8G6D5; -.
DR STRING; 8355.A0A1L8G6D5; -.
DR PaxDb; 8355-A0A1L8G6D5; -.
DR GeneID; 108716445; -.
DR KEGG; xla:108716445; -.
DR AGR; Xenbase:XB-GENE-6486947; -.
DR CTD; 108716445; -.
DR Xenbase; XB-GENE-6486947; traf5.L.
DR OMA; CPIDHER; -.
DR OrthoDB; 2913784at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 108716445; Expressed in spleen and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16642; mRING-HC-C3HC3D_TRAF5; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR049440; TRAF3/5_RING.
DR InterPro; IPR027130; TRAF5_C3HC3D_RING-HC_finger.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF83; TNF RECEPTOR-ASSOCIATED FACTOR 5; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF21363; TRAF3_RING; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 3.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614};
KW Receptor {ECO:0000313|RefSeq:XP_018118064.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 555 AA; 63985 MW; B16225833B1CA09C CRC64;
MACEDLCPLP VTFARQNSST AVSLDFVPKQ GYLFVEQLQD RYKCASCHLV LHNPHQTGCG
HRFCEKCISN LIDLSETPQC PIDMETIKPH EIFKDNCCKR EVLNLLVYCK NSPGCDVKVM
LGRYQEHLVQ CLYETTQCSN EGCHDKMLRK ELKGHLESEC KLRPEACIYC KQIMASINLT
IHVGLYCPLY PVSCPNACPV TCPRAELDKH LYVCPEAELQ CPFTNYGCNV KVKRGNMKEH
EDTFLRDHML HVLNRNMKLE EQVLDLQQNL KLKEHQIQKL SDTVKWCENE CNQFGQFTGS
NGNPLSSTMT LASYIDKSVW LEEQVLQLVS KEHSRFDLRP ILDTLETTKE RISTMETYKD
HIDNLDCEFK KHDMLLSSHK MQMTSNEERF RLLEGTSYNG KLIWKIADYE RKKREAIEGR
TLSIFSQHFY TSWCGYRLCA RAYLNGDGSG KGSFLSLYFV VMKGEFDSIL PWPFKQKVTL
MLLDQSRKKN HITDIFRADP NSSSFKRPDS EMNIASGCPR FASHAQLENP KNGCYIKDDT
LFIKVVVDLT DLEEV
//
