ID A0A1L8G7F5_XENLA Unreviewed; 134 AA.
AC A0A1L8G7F5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Cystatin {ECO:0000313|RefSeq:XP_018118354.1};
GN Name=LOC108716611 {ECO:0000313|RefSeq:XP_018118354.1,
GN ECO:0000313|RefSeq:XP_041418288.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018118354.1};
RN [1] {ECO:0000313|RefSeq:XP_018118354.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018118354.1,
RC ECO:0000313|RefSeq:XP_041418288.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018118354.1,
RC ECO:0000313|RefSeq:XP_041418288.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the cystatin family.
CC {ECO:0000256|ARBA:ARBA00009403}.
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DR RefSeq; XP_018118354.1; XM_018262865.2.
DR RefSeq; XP_041418288.1; XM_041562354.1.
DR STRING; 8355.A0A1L8G7F5; -.
DR PaxDb; 8355-A0A1L8G7F5; -.
DR GeneID; 108716611; -.
DR KEGG; xla:108716611; -.
DR OMA; GRTRCEN; -.
DR OrthoDB; 3086783at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 108716611; Expressed in stomach and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR027358; Kininogen-type_cystatin_dom.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR46186; CYSTATIN; 1.
DR PANTHER; PTHR46186:SF2; CYSTATIN-RELATED; 1.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
DR PROSITE; PS51647; CYSTATIN_KININOGEN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasodilator {ECO:0000256|ARBA:ARBA00022429}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..134
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041053327"
FT DOMAIN 33..134
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
SQ SEQUENCE 134 AA; 14493 MW; D3E209E862C9D200 CRC64;
MSSSVYLVLV LSLSLLVTLA STGMPGAPVA ANTGSEEVKN AANFALERFN LMSTNKHIYK
LLTVKSAKTQ VVAGRNYILE IIIGATNCQK NSHYNLQACK LTLGANAKLQ NCTFEVYVSW
NNVMSLSKST CKTL
//
