ID   A0A1L8G7M7_XENLA        Unreviewed;       855 AA.
AC   A0A1L8G7M7;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Rho guanine nucleotide exchange factor 33 isoform X3 {ECO:0000313|RefSeq:XP_041418621.1};
GN   Name=arhgef33.L {ECO:0000313|RefSeq:XP_041418621.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041418621.1};
RN   [1] {ECO:0000313|RefSeq:XP_041418621.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041418621.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041418621.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_041418621.1; XM_041562687.1.
DR   AlphaFoldDB; A0A1L8G7M7; -.
DR   STRING; 8355.A0A1L8G7M7; -.
DR   PaxDb; 8355-A0A1L8G7M7; -.
DR   OMA; LEHANMV; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR042849; ARHGEF33.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR46944; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR   PANTHER; PTHR46944:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ   SEQUENCE   855 AA;  98025 MW;  E20A029BB31625D7 CRC64;
     MHLQLRPSCP NRRNLNRSEV TYGETENIPV SGLPAQIYQL QALASELKSG FSEAMQELSR
     IQHGEYALEE KVKSCRCTME EKVTEVKNSL NNLKEEVNTA MAMIHAIIAK QEEMQQKIEQ
     LQQEKRRESR KVKNKRLQKE EPMAQPQVPP NGNFLQPSLS ESTVVNHHFN NIAQPSPFEK
     VPASRLVTAN DCNMAAITTA SRVTQEDSEK SYTTSTLIET QQKAYMPSHI WRQPKDERES
     NEENSPKEQP DRIRDTGRNR SAPVENVLSE PTGFARRQNA ARDLLESERK YVLNLSHILK
     IRATLQGSDI KRATKERSSL RYLIQHHLDL LHVLQERVIK WSREGILGDI FLKLTNDENN
     FLDYYVAYLK DLPESISVIH IVVLKEAEED IKSDLYILLF HVVQRIPEYL IILQNILKFT
     EQEHPDYYLL LVCVQRLRVF ISHYSVLFQY NEDLLIQKRK KLKKSSMIKL YKGLASQCSG
     SSQEVPPSVN TSSIIKENII QSDETHQLYP AMPGSNLNLV PQIKKGRQTP VENIQPLKSS
     EWEADGKKHD RPDIIVPTPY SGPDQEVNSL LSPLQSIPEM EYESTSVDAL LDMERSKRTS
     SNIFSHGNLA PNYEEYEYGS EIIGVSTPYE EDPFPNHPLF ESCSAASSES SLDICFLRPI
     NFTLESNRTE RSLQPASRNC FSPVSNSSYR HEGIHIKNKP LSRSLKEFPR NQEAVSTRLY
     SARCTSASRM QFKQDRSTQS HGSDSARNSH RQFYIPQRPH ADSRSLLEDI QMDGNARFYH
     KDETEQTSFS EHHPRPDQKG GFRSSFRKLF KKKSGGLESK EKSSEKSSLD QSPTRQEIFR
     HHSALISELD RGTAV
//