ID A0A1L8G7P7_XENLA Unreviewed; 261 AA.
AC A0A1L8G7P7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Synapse differentiation-inducing gene protein 1 {ECO:0000256|ARBA:ARBA00040240};
DE AltName: Full=Dispanin subfamily C member 2 {ECO:0000256|ARBA:ARBA00041354};
DE AltName: Full=Transmembrane protein 90B {ECO:0000256|ARBA:ARBA00042246};
GN Name=syndig1.L {ECO:0000313|RefSeq:XP_018118356.1,
GN ECO:0000313|Xenbase:XB-GENE-6488028};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018118356.1};
RN [1] {ECO:0000313|RefSeq:XP_018118356.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018118356.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018118356.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May regulate AMPA receptor content at nascent synapses, and
CC have a role in postsynaptic development and maturation.
CC {ECO:0000256|ARBA:ARBA00037790}.
CC -!- SUBUNIT: Homodimer. Interacts with GRIA1 and GRIA2.
CC {ECO:0000256|ARBA:ARBA00038680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell
CC projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC {ECO:0000256|ARBA:ARBA00006843}.
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DR RefSeq; XP_018118356.1; XM_018262867.2.
DR AlphaFoldDB; A0A1L8G7P7; -.
DR STRING; 8355.A0A1L8G7P7; -.
DR PaxDb; 8355-A0A1L8G7P7; -.
DR GeneID; 108716613; -.
DR KEGG; xla:108716613; -.
DR AGR; Xenbase:XB-GENE-6488028; -.
DR CTD; 108716613; -.
DR Xenbase; XB-GENE-6488028; syndig1.L.
DR OMA; MHSKITE; -.
DR OrthoDB; 4253341at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 108716613; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR PANTHER; PTHR14768:SF3; SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1; 1.
DR PANTHER; PTHR14768; UPF0338 PROTEIN; 1.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ SEQUENCE 261 AA; 29348 MW; A401855254E52E87 CRC64;
MQNMDGLIEQ NNVLLHNKIT EAGKKNGLIN TRNLMAENKD GMVSVYPTPQ YQSHIVGNIS
PQIGRDSIKN EPVQQLLDPN MLQKTVESHY RPNIILYSEN VLRSWGENVS SECCETTFIE
DRSPTKDSLD YPDSKFIDLS SEDIKIHTLS YDVEEEEDFQ ELESDYSSDT ESEDNFLMMP
PRDHLGLSVF SMLCCFWPLG IAAFYLSHET NKAVAKGDFH QASSSSRRAL FLAVLSITIG
TGIYVGVAVA LIAYLSKNNH L
//
