ID A0A1L8G9R5_XENLA Unreviewed; 470 AA.
AC A0A1L8G9R5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Cannabinoid receptor {ECO:0000256|PIRNR:PIRNR037995};
GN Name=cnr1.L {ECO:0000313|RefSeq:XP_018118890.1,
GN ECO:0000313|Xenbase:XB-GENE-17341869};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018118890.1};
RN [1] {ECO:0000313|RefSeq:XP_018118890.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018118890.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018118890.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: G-protein coupled receptor for cannabinoids. Mediates many
CC cannabinoid-induced effects in the central nervous system (CNS), as
CC well as in peripheral tissues. Signaling typically involves reduction
CC in cyclic AMP. {ECO:0000256|PIRNR:PIRNR037995}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, axon {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004294}. Presynapse
CC {ECO:0000256|ARBA:ARBA00034106}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|PIRNR:PIRNR037995, ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_018118890.1; XM_018263401.2.
DR AlphaFoldDB; A0A1L8G9R5; -.
DR STRING; 8355.A0A1L8G9R5; -.
DR PaxDb; 8355-A0A1L8G9R5; -.
DR GeneID; 108716878; -.
DR KEGG; xla:108716878; -.
DR AGR; Xenbase:XB-GENE-17341869; -.
DR CTD; 108716878; -.
DR Xenbase; XB-GENE-17341869; cnr1.L.
DR OMA; QCGENIV; -.
DR OrthoDB; 5258261at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 108716878; Expressed in brain.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0004949; F:cannabinoid receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000810; Canbinoid_rcpt_1.
DR InterPro; IPR002230; Cnbnoid_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR22750:SF47; CANNABINOID RECEPTOR 1; 1.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PIRSF; PIRSF037995; Cnoid_rcpt_1; 1.
DR PRINTS; PR00522; CANABINOID1R.
DR PRINTS; PR00362; CANNABINOIDR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR037995};
KW G-protein coupled receptor {ECO:0000256|PIRNR:PIRNR037995,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037995};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Receptor {ECO:0000256|PIRNR:PIRNR037995, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transducer {ECO:0000256|PIRNR:PIRNR037995, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 133..397
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 470 AA; 52880 MW; C98B2BB7B3EA044E CRC64;
MKSILDGLAD TTFRTITTDL LYMGPNEVQY DDSKGDISSK LVYFPQKLPL SSLRGDPSHE
KMTIIDDPLL SIPLDQINST DFYNKSIIFK DTDDNVQCGK NFMDMECFMI LNPSQQLVIA
ALSIILGTFT VLENMLVLIV IVQSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFVDFHVF
HRKDSPNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLSYKRIVTR TKAVIAFCMM
WTIAIVIAVL PLFGWNCIKR RSVCSDIFPL IDETYLMFWI GVTSILLLFI VYAYMYILWK
AHTHAVRMLQ RGTQKSIIVH TSEDGKVHIT RPDQTRMDIR LAKTLVLILV VLIICWGPLL
AIMVYDVFGE INKMIKTVFA FCSVLCLLNS TVNPIIYALR SQDLRNAFCS MFPSCKGTAQ
PLDNSMESDC QNRHVNNSNV HRAAESCIKS TVKIAKVTMS VSTDTSAEAV
//
