ID A0A1L8GAL2_XENLA Unreviewed; 501 AA.
AC A0A1L8GAL2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=2-phosphoxylose phosphatase 1 {ECO:0000256|ARBA:ARBA00040357};
DE AltName: Full=Acid phosphatase-like protein 2 {ECO:0000256|ARBA:ARBA00041499};
GN Name=pxylp1.L {ECO:0000313|RefSeq:XP_018119323.1,
GN ECO:0000313|Xenbase:XB-GENE-6488319};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018119323.1};
RN [1] {ECO:0000313|RefSeq:XP_018119323.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018119323.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018119323.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-
CC beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-
CC beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:56512, Rhea:RHEA-COMP:12573, Rhea:RHEA-
CC COMP:14559, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:132093,
CC ChEBI:CHEBI:140495; Evidence={ECO:0000256|ARBA:ARBA00036311};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR RefSeq; XP_018119323.1; XM_018263834.2.
DR AlphaFoldDB; A0A1L8GAL2; -.
DR STRING; 8355.A0A1L8GAL2; -.
DR PaxDb; 8355-A0A1L8GAL2; -.
DR GeneID; 108717080; -.
DR KEGG; xla:108717080; -.
DR AGR; Xenbase:XB-GENE-6488319; -.
DR CTD; 108717080; -.
DR Xenbase; XB-GENE-6488319; pxylp1.L.
DR OMA; DWEWNYY; -.
DR OrthoDB; 3403603at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 108717080; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF125; 2-PHOSPHOXYLOSE PHOSPHATASE 1; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
SQ SEQUENCE 501 AA; 57893 MW; 9EE92D46FCCE1FE3 CRC64;
MLLRNRFLLL LALAGLLAFL SLSLQFFSRW LPVSLQLKTE MQVFPEFPVR LIPADQVRGE
GLSAKNRKRI MPEPLTEPPA LDPLYEANLY CNTPGAKEKS MEGHAPPNLK LLSVQVIIRH
GDRYPLYAIP KTKRPDIDCV LEPTRKPSHP HLTDFISHMS RGVEAQMEGT LSSLPRLPNH
ILCEMGELTQ TGVVQHLRNG QLLKEIYLKK HRLLPSAWTA KHLYFESTGK SRTLQSGLAL
LYSFLPNFDW KKINIKHQWS TIFCSNHCDC PMRNHFLEEE QRRQYSLRVK NNLLEKTYIN
MAKIVGIPTR QLRASNPIDS LLCNFCHNAS FPCTKNGCID LEHFKVIKTH QLEDEKERHE
KQLYFKYALM ATHPLLNQTA NRMLHIAGGK REEIFALYAA HDVTLSPVLS ALGLKEARFP
RFAARLVFEL WHDPDKASDH YVRVLYNGED VTFQTSFCRD QQRSSRRPLC PLKKFSTFIQ
KEMFLSLNST GYYDACHQRL F
//
