ID   A0A1L8GF21_XENLA        Unreviewed;      1211 AA.
AC   A0A1L8GF21;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=dhx38.S {ECO:0000313|RefSeq:XP_018116029.1,
GN   ECO:0000313|Xenbase:XB-GENE-17336232};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018116029.1};
RN   [1] {ECO:0000313|RefSeq:XP_018116029.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018116029.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018116029.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_018116029.1; XM_018260540.2.
DR   RefSeq; XP_018116030.1; XM_018260541.1.
DR   AlphaFoldDB; A0A1L8GF21; -.
DR   STRING; 8355.A0A1L8GF21; -.
DR   PaxDb; 8355-A0A1L8GF21; -.
DR   GeneID; 108715422; -.
DR   KEGG; xla:108715422; -.
DR   AGR; Xenbase:XB-GENE-17336232; -.
DR   CTD; 108715422; -.
DR   Xenbase; XB-GENE-17336232; dhx38.S.
DR   OMA; VDVMFHR; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 108715422; Expressed in neurula embryo and 19 other cell types or tissues.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd17983; DEXHc_DHX38; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806,
KW   ECO:0000313|RefSeq:XP_018116029.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ   SEQUENCE   1211 AA;  138219 MW;  4B92699D2A79EE05 CRC64;
     MEDDLSLHRL EGSDPSLETG GLVIKKKSSI NEQHVFKAPA PRSSLLGLDL LAAQKRKERE
     EKEQQEGEKK PKVSSRDSEE KDRSSDRPND KLSRGSHGDR HYRTARVETP SYTGGVNEEF
     LARNRQRERE RREHGVYASS KDDRQRRKDR GREREDRSHR NRSERDSGSE RSARRSEPES
     PRHRARDAST PSRSNWEEDD SGYGGSQRSQ WESPSPAPSN KDSERSHRSE RESSRRERSE
     RGRYSEESPL PTPSYKYNEW ASDRRHLGST PRLSQGRGKQ DNEDDKINFI SEEEQQQWED
     DQRQADRDWY MMDEGFDESH NALTSSSEDY VKKREQQLQK QSTKRVSAQR RQINEDNERW
     ETNRMLTSGV VQRLEVDEDF EEDNAAKVHL LVHNLVPPFL DGRIVFTKQP EPVIPVRDAT
     SDLAIIARKG SQLVRKHREQ KERKKAQHKH WELAGTKLGD IMGVKKQADE SDKPVAEDGG
     VDYKTEQKFA DHMRERSEAS SDFSRKKSLM EQRQYLPIFA VQQELLTIIR DNSIVIVVGE
     TGSGKTTQLT QYLHEDGYTD YGMIACTQPR RVAAMSVAKR VSEEMQVSLG EEVGYAIRFE
     DCTSEKTLIK YMTDGILLRE CLRESDLDNY SAVIMDEAHE RSLNTDVLFG LLREVVTRRS
     DLKLIVTSAT MDAEKFAAFF GNVPIFHIPG RTFPVDILFS KTPQEDYVEA AVKQALQIHL
     SGAAGDILIF MPGQEDIEVT SDQIVERLEE LDSAPPLAVL PIYSQLPSDL QAKIFQKAPD
     GVRKCIVATN IAETSLTVDG IMFVIDSGYC KLKVFNPRIG MDALQIYPIS QANANQRSGR
     AGRTGPGQCY RLYTQSAFKN ELLHTAVPEI QRTNLSNVVL LLKSLGVQDL LLFHFMDPPP
     EDNMLNSMYQ LWILGALDNT GALTSTGRLM VEFPLDPALS KMLIVSCDMG CSSEILIVVS
     MLSVPAIFYR PKGREEESDQ IREKFAVPES DHLTYLNVFL QWKNNNYSSG WCNQHFIHAK
     AMRKVREVRA QLKDIMVSQR MSLSSCGSDW DIVRKCICAA YFHQAARLKG IGEYVNVRTG
     MPCHLHPTSS LFGMGYTPDY IVYHELVMTT KEYMQCVTAV DGEWLAELGP MFYSIKHAGK
     SRQENKRRAK EEVSAMEEEM MLAEEQLRSR REEQQKKNVL GSARSLKIYT PGRKDQVEPG
     TPRRTPARFG L
//