ID A0A1L8GF82_XENLA Unreviewed; 733 AA.
AC A0A1L8GF82;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Adhesion G protein-coupled receptor L4 {ECO:0000313|RefSeq:XP_018116206.1};
GN Name=adgrl4.S {ECO:0000313|RefSeq:XP_018116206.1,
GN ECO:0000313|Xenbase:XB-GENE-17338314};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018116206.1};
RN [1] {ECO:0000313|RefSeq:XP_018116206.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018116206.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018116206.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_018116206.1; XM_018260717.2.
DR AlphaFoldDB; A0A1L8GF82; -.
DR STRING; 8355.A0A1L8GF82; -.
DR PaxDb; 8355-A0A1L8GF82; -.
DR GeneID; 108715501; -.
DR KEGG; xla:108715501; -.
DR AGR; Xenbase:XB-GENE-17338314; -.
DR CTD; 108715501; -.
DR Xenbase; XB-GENE-17338314; adgrl4.S.
DR OMA; WDENTIG; -.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 108715501; Expressed in lung and 15 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR12011:SF59; ADHESION G PROTEIN-COUPLED RECEPTOR L4; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|RefSeq:XP_018116206.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 56..94
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 106..142
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 470..711
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 733 AA; 81823 MW; 6C5781E22E7B0F75 CRC64;
MKQLYLIVCI ISLLGQGYQQ CSISCHVNAK CKTENGAVGC YCANGYTGDG INFCQDDNEC
QNATNICGEN ANCTNTDGGY YCTCVPGFYS SGAERFVTND GTYCTDEDEC NAKNCGYNAE
CKNTAGGYDC FCKEGYQPSS GRLLFKADDG TYCQESYKLR CHLDDSCISF SINKTISQVT
TIKEPNAILN EIQRNTAREL LPIDVISFVE VLAASSSLLS TVNNSVLNKE NATIITFVKT
VNNFVEKDKI KVWKNLRDDS RIKSITKLMH TTEHTALEMS QNFKKTTQLS INASDMALKL
FTFDSNHMKH THPHVFIEGD SIKISSKKKE SSLSNGTVAI VFLRYENIGV LLGSNANTSI
KEHDSVDQRA LVNSPVIAAA IKSNPPTLYQ LEKITFILKH REIFSDVGAT KCAFWSYKEE
TMNGEWSTNG CEVLASNSTH TSCRCNHLTH FAILMSSSSR NQVASHHSVL TRITQLGIII
SLICLSLCIF TFLFFSEIQS TRTTIHKNLC CALFLAELLF IIGINMTKNK LFCAVVAGLL
HYFFLAAFAW MCIEGIHLYL IVVGVIYNRG FLHKNFYIFG YCSPAVVVGI SAILGYKYYG
TDKVCWLSTE NNFIWSFIGP ACLIILVNLM AFGVIIYKVF RHTAMLKPEV TCYENIRSCA
RGALALLFLL GATWMFGVLH VVNGSLVTAY LFTISNAFQG MFIFIFLCVL SKKIQEEYYR
LFKNVPCCFT CLR
//
