ID A0A1L8GFB9_XENLA Unreviewed; 352 AA.
AC A0A1L8GFB9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=deoxyribonuclease II {ECO:0000256|ARBA:ARBA00012036};
DE EC=3.1.22.1 {ECO:0000256|ARBA:ARBA00012036};
GN Name=dnase2b.S {ECO:0000313|RefSeq:XP_018116188.1,
GN ECO:0000313|Xenbase:XB-GENE-17338614};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018116188.1};
RN [1] {ECO:0000313|RefSeq:XP_018116188.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018116188.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018116188.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-
CC phosphooligonucleotide end-products.; EC=3.1.22.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000447};
CC -!- SIMILARITY: Belongs to the DNase II family.
CC {ECO:0000256|ARBA:ARBA00007527}.
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DR RefSeq; XP_018116188.1; XM_018260699.2.
DR AlphaFoldDB; A0A1L8GFB9; -.
DR STRING; 8355.A0A1L8GFB9; -.
DR PaxDb; 8355-A0A1L8GFB9; -.
DR GeneID; 108715496; -.
DR KEGG; xla:108715496; -.
DR AGR; Xenbase:XB-GENE-17338614; -.
DR CTD; 108715496; -.
DR Xenbase; XB-GENE-17338614; dnase2b.S.
DR OMA; HMPQLCA; -.
DR OrthoDB; 4662at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 108715496; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0004531; F:deoxyribonuclease II activity; IEA:UniProtKB-EC.
DR CDD; cd09192; PLDc_DNaseII_beta_2; 1.
DR InterPro; IPR004947; DNase_II.
DR PANTHER; PTHR10858; DEOXYRIBONUCLEASE II; 1.
DR PANTHER; PTHR10858:SF2; DEOXYRIBONUCLEASE-2-BETA; 1.
DR Pfam; PF03265; DNase_II; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ SEQUENCE 352 AA; 40779 MW; 548C7AD6DF1E359E CRC64;
MLGLYHFAVV YLPAMSMVAA EISCRNEAGD PIDWFVVYKL PMLNDSTGSG LDYLYMDSTN
QEWQISKFQI NTTKSAVGQV LQQLYQDYDK DDTVYMIYND APPNVKNSSR KGHTKGVLFF
DTSQGFWLIH SVPHFPPSPE DGYGYPSTGK RFGQTAICVT YPYSEFKEIA NQLLYYNPNV
YNCSVPNMYQ KELWMLHKIC LGGHFPWIDS TRLTQLNSAR GEVFLNFAKS KYFVDDIYTA
WIAQKLRTNM FVESWISREQ LPSNCSLQYH VYNIKRIGLP TQSSFQSFYD HSKWCVSQSN
GDLWTCIGDL NRHPLQTRRS GGFICTQNKH IYTAFRNMVL YYKNCTDTEN KM
//
