ID A0A1L8GGF2_XENLA Unreviewed; 808 AA.
AC A0A1L8GGF2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Breast cancer anti-estrogen resistance protein 3 homolog isoform X1 {ECO:0000313|RefSeq:XP_018116487.1};
GN Name=bcar3.S {ECO:0000313|RefSeq:XP_018116487.1,
GN ECO:0000313|RefSeq:XP_041417455.1,
GN ECO:0000313|Xenbase:XB-GENE-17333998};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018116487.1};
RN [1] {ECO:0000313|RefSeq:XP_018116487.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018116487.1,
RC ECO:0000313|RefSeq:XP_041417455.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018116487.1,
RC ECO:0000313|RefSeq:XP_041417455.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
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DR RefSeq; XP_018116487.1; XM_018260998.2.
DR RefSeq; XP_018116488.1; XM_018260999.1.
DR RefSeq; XP_041417455.1; XM_041561521.1.
DR STRING; 8355.A0A1L8GGF2; -.
DR PaxDb; 8355-A0A1L8GGF2; -.
DR GeneID; 108715655; -.
DR KEGG; xla:108715655; -.
DR CTD; 108715655; -.
DR Xenbase; XB-GENE-17333998; bcar3.S.
DR OMA; GLLEWEF; -.
DR OrthoDB; 2953960at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 108715655; Expressed in muscle tissue and 19 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 154..253
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 540..807
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 313..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 92514 MW; 96F88AA22DD2BB3B CRC64;
MAAGKSASYH RNVQMNHQFP LVSSMDLLGS KSALGERRKD LFQNVCIHGT LPRKKKERVP
IRSSDMFCHM GTLPHTKSHK LPDPLMQDIT EAYPLQERRT KIFSMREHYL DPSMEYVKFS
KDRYIMDGGT PDKLKKELEE ELKLNSEDLR SHAWYHGRIP RQVSESLVKR DGDFLIRDSL
SSPGNFVLTC QWKNLSQHFK INKVVTRLNE AYCRIQYQLE HESFDSIPAL VRYYVGNRKA
VLQQSGAIIF QPINRTVPLR CIEEKYGTSP VKRLELDIME GKAEPTKRLS LNFGQGVSQE
QCLARGNLLR NKEKSGSQPA CLDNMREKRR PLKAHQSESY LPLGSRQPYL SQGMDMKASP
KPHVFRTGSE PTLSPTEIRR FNHEAHPSEA LRGSDSQLCP RPPPKPTKAP SIKQSQSPLV
WQPSEANYCE LHPTPPEDCA WSDSHSSHNS YIEDQRRDEI ETLSFCNSEL SFPALEDRIS
QCSATDFCGD IEDDEFIGPV YETVSSFCPN DFQSVLLTKE NKPLEMALLR RAKELFTNND
PRTIAKHILR MDCKVARILD VSPEVERMMG VSSGLELIIL PYGHQLRLDL MERHTTMAIG
IAVDILGCTG NLEERVATLH KIIQLAVEVK TLGDYFAFSA IMKALDMPQI TRLEQTWTML
RHQYTQTAIT YEKQLKPFSK NLYEGEGLDA QEDTTVPLVM PLVTLLERQS VIFEGMDLWE
KNDRGCEIMF NNLQTARQVA QNATVYKKNA ERILEGFKPD ELMSEIFKTE FQMRLLWGSK
GALLKQSERY HKFGQILTAL SRKLEPPS
//