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Database: UniProt
Entry: A0A1L8GGF2_XENLA
LinkDB: A0A1L8GGF2_XENLA
Original site: A0A1L8GGF2_XENLA 
ID   A0A1L8GGF2_XENLA        Unreviewed;       808 AA.
AC   A0A1L8GGF2;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Breast cancer anti-estrogen resistance protein 3 homolog isoform X1 {ECO:0000313|RefSeq:XP_018116487.1};
GN   Name=bcar3.S {ECO:0000313|RefSeq:XP_018116487.1,
GN   ECO:0000313|RefSeq:XP_041417455.1,
GN   ECO:0000313|Xenbase:XB-GENE-17333998};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018116487.1};
RN   [1] {ECO:0000313|RefSeq:XP_018116487.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018116487.1,
RC   ECO:0000313|RefSeq:XP_041417455.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018116487.1,
RC   ECO:0000313|RefSeq:XP_041417455.1};
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
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DR   RefSeq; XP_018116487.1; XM_018260998.2.
DR   RefSeq; XP_018116488.1; XM_018260999.1.
DR   RefSeq; XP_041417455.1; XM_041561521.1.
DR   STRING; 8355.A0A1L8GGF2; -.
DR   PaxDb; 8355-A0A1L8GGF2; -.
DR   GeneID; 108715655; -.
DR   KEGG; xla:108715655; -.
DR   CTD; 108715655; -.
DR   Xenbase; XB-GENE-17333998; bcar3.S.
DR   OMA; GLLEWEF; -.
DR   OrthoDB; 2953960at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 108715655; Expressed in muscle tissue and 19 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd10337; SH2_BCAR3; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR   PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR   PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          154..253
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          540..807
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          313..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   808 AA;  92514 MW;  96F88AA22DD2BB3B CRC64;
     MAAGKSASYH RNVQMNHQFP LVSSMDLLGS KSALGERRKD LFQNVCIHGT LPRKKKERVP
     IRSSDMFCHM GTLPHTKSHK LPDPLMQDIT EAYPLQERRT KIFSMREHYL DPSMEYVKFS
     KDRYIMDGGT PDKLKKELEE ELKLNSEDLR SHAWYHGRIP RQVSESLVKR DGDFLIRDSL
     SSPGNFVLTC QWKNLSQHFK INKVVTRLNE AYCRIQYQLE HESFDSIPAL VRYYVGNRKA
     VLQQSGAIIF QPINRTVPLR CIEEKYGTSP VKRLELDIME GKAEPTKRLS LNFGQGVSQE
     QCLARGNLLR NKEKSGSQPA CLDNMREKRR PLKAHQSESY LPLGSRQPYL SQGMDMKASP
     KPHVFRTGSE PTLSPTEIRR FNHEAHPSEA LRGSDSQLCP RPPPKPTKAP SIKQSQSPLV
     WQPSEANYCE LHPTPPEDCA WSDSHSSHNS YIEDQRRDEI ETLSFCNSEL SFPALEDRIS
     QCSATDFCGD IEDDEFIGPV YETVSSFCPN DFQSVLLTKE NKPLEMALLR RAKELFTNND
     PRTIAKHILR MDCKVARILD VSPEVERMMG VSSGLELIIL PYGHQLRLDL MERHTTMAIG
     IAVDILGCTG NLEERVATLH KIIQLAVEVK TLGDYFAFSA IMKALDMPQI TRLEQTWTML
     RHQYTQTAIT YEKQLKPFSK NLYEGEGLDA QEDTTVPLVM PLVTLLERQS VIFEGMDLWE
     KNDRGCEIMF NNLQTARQVA QNATVYKKNA ERILEGFKPD ELMSEIFKTE FQMRLLWGSK
     GALLKQSERY HKFGQILTAL SRKLEPPS
//
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