ID A0A1L8GGH9_XENLA Unreviewed; 843 AA.
AC A0A1L8GGH9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Guanine nucleotide exchange factor VAV3 isoform X2 {ECO:0000313|RefSeq:XP_018116576.1};
GN Name=vav3.S {ECO:0000313|RefSeq:XP_018116576.1,
GN ECO:0000313|Xenbase:XB-GENE-17336610};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018116576.1};
RN [1] {ECO:0000313|RefSeq:XP_018116576.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018116576.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018116576.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_018116576.1; XM_018261087.2.
DR AlphaFoldDB; A0A1L8GGH9; -.
DR STRING; 8355.A0A1L8GGH9; -.
DR PaxDb; 8355-A0A1L8GGH9; -.
DR GeneID; 108715695; -.
DR KEGG; xla:108715695; -.
DR AGR; Xenbase:XB-GENE-17336610; -.
DR CTD; 108715695; -.
DR Xenbase; XB-GENE-17336610; vav3.S.
DR OMA; VFINIPX; -.
DR OrthoDB; 2911406at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 108715695; Expressed in spleen and 14 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20869; C1_VAV3; 1.
DR CDD; cd21264; CH_VAV3; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11981; SH3_VAV3_1; 1.
DR CDD; cd11978; SH3_VAV3_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR047015; VAV3_SH3_1.
DR InterPro; IPR035734; VAV3_SH3_2.
DR PANTHER; PTHR45818:SF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT REGION 567..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 97288 MW; 1D0198259F1354D0 CRC64;
MEPWRQCAQW LIRCRVLPPN HRVTLDTAQV FDLAQTLRDG VLLCQLLKNL QGSSINLKEI
NLRPQMSQFL CLKNIRTFLS VCCGAFSMKK SDLFESFDLF DVRDFAKVIE TLSKLSHTTI
SLSAGIRPFP TEESVQDEDI YKALPDLIDE SGADEDEELY YDSVYQEDDG GEVYEDLMKA
EAALPNRSAE SDVRSCCLLE IKQTEEKYSE TLDSIEKFFM EPLKNFLTPT DIQNVFINIS
EMVEVHKNLM KEIKDSANHR NSQNLYVIFL TYKERLLIYG EYCSQVELAI SLLDNISKTR
EDVRLKLEEC SKRANNGKFT LRDLLVVPMQ RVLKYHLLLQ ELVKHTTEPT EKNNLRVALD
AMKDLAQYVN EVKRDTETLR EIEQYQHSIE NLNQPMSQYG RPKVDGEIKI CTLDKRTRQD
RYIFLFDQAV IVCKRRGDNY DMKEIIDLQK YKITNNPSTD KENKKWSYGF YLTHIQGQNG
FEFFCKTKDL KKKLLEQFEM ALSNIRPDNA TANYHEFQMH SFKNVTSCRV CQMLLRGTFF
QGYLCQKCGT GAHKECLGRV DTCGRADSGS LKPEKQNGPR RPVKHPDPGL PKMKVIRNYS
GFPSPPAHSG PSLSMQIGDT IEVLRADPHI LFWQGRNIAT GELGFFPSDA VKPCPCVPKP
LDYSGQPWFA GAMERVQAES ELISRENSTY LIRHRTKESG EYAISIKYNN EVKHIKILTR
DGFFHIAENR RFKSLMELVE YYKHQSLREG FRSLDTKLLL PYKFPENNTG HVCNQTSGMF
FSPKVLGIAI ARYDFCARDM RELSLFKGDV VKIYTKSGTN GWWRGESNGK VGWFPSTYVE
DDE
//
