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Database: UniProt
Entry: A0A1L8GHJ0_XENLA
LinkDB: A0A1L8GHJ0_XENLA
Original site: A0A1L8GHJ0_XENLA 
ID   A0A1L8GHJ0_XENLA        Unreviewed;      2693 AA.
AC   A0A1L8GHJ0;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   07-NOV-2018, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OCT83302.1};
GN   ORFNames=XELAEV_18025839mg {ECO:0000313|EMBL:OCT83302.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:OCT83302.1, ECO:0000313|Proteomes:UP000186698};
RN   [1] {ECO:0000313|Proteomes:UP000186698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J {ECO:0000313|Proteomes:UP000186698};
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J.,
RA   Quigley I., Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B.,
RA   Simakov O., Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T.,
RA   Watanabe M., Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S.,
RA   van Kruijsbergen I., Shu S., Carlson J., Kinoshita T., Ohta Y.,
RA   Mawaribuchi S., Jenkins J., Grimwood J., Schmutz J., Mitros T.,
RA   Mozaffari S.V., Suzuki Y., Haramoto Y., Yamamoto T.S., Takagi C.,
RA   Heald R., Miller K., Haudenschild C., Kitzman J., Nakayama T.,
RA   Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., Karimi K.,
RA   Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., Shendure J.,
RA   DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y.,
RA   Veenstra G.J., Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
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DR   EMBL; CM004473; OCT83302.1; -; Genomic_DNA.
DR   UniGene; Xl.101; -.
DR   Proteomes; UP000186698; Chromosome 4s.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186698};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A1L8GHJ0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2221   2243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2255   2273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2301   2319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2339   2366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2387   2409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2514   2537       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      364    420       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1580   1600       {ECO:0000256|SAM:Coils}.
FT   COILED     2631   2672       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2693 AA;  306745 MW;  E51D4B7488BE86C5 CRC64;
     MSDKMSSFLH VGDIVSLYAE GSVNGFINTL GLVDDRSVVQ PDAGDLNNPP KKFRDCLFRL
     CPMNRYSAQK QFWKAAKPGA SSTTDTVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSQQL SDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEIDA EPDAGNARMQ VVPEKMMCTL ISVPEGNDIS SIFELDPTTL
     RGGDSLVPRN SYVRLRHLCT NTWVHSTNSP IDKDEEKPVM LRIGTSPVKE DKEAFAIVPV
     SPAEVRDLDF ANDASKVLSS IAGKLEKGTI TQNERRAVTK LLEELVYFVT GLVNSGHDIL
     EVLVNKPNRE RQKLMREQNI LKQIFKLLQA PFTDSGDGPM LRLEELGDQR HAPFRHICRL
     CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
     DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPANADIL IETKLVLSRF
     EFEGVASGES SLEAGEDEEE VWLFWKASNK EIRSRSVREL AQDAKEGQKE DQDVLNYYRY
     QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPF DLRASFCRLM LHMHVDRDPQ
     EQVTPVKYAR LWSEIPSEIA IDDYDSSGTS RDDIKERFAQ TMEFVEEYLR DVVGQRFPFA
     DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIV DCVHLIANFP SGKLGKGEES
     KGGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAPEGTI KAQREPEKED ILVMDTKLKI
     IEILQFILNV RLDYRISCLL CIFKSEFDES NAQSVEGSTE AMTVVPGTLD FEHIEEQAEG
     IFGGRKENTP LDLDDDGGRT FLRVLLHLTM HDYPPLVSGA LHLLFRHFSQ RQEVLQAFKQ
     VQLLVTSQDV DNYKQIKQDL DQLRSIVEKS ELWVYKGSGP EEVTAAQAGG ADKGETPGKA
     KKSESTSSYN YRVVKEILLR LSKLCVQENT TGRRNRKQQQ RLLRNMGAHS VVLELLQIPY
     EKTEDTRMQE IMKIAHEFLQ NFCAGNQQNQ ALLHKHINLF LTPGILEAVT MQHIFMNNFQ
     LCSEINERVV QHFAHCIETH GRNVQYIKFL QTIVKAEGRY IKKCQDIVMA ELVNSGEDVL
     VFYNDRASFQ TLVQMMRSER ERMDENSPLM YHIHLVELLA VCTEGKNVYT EIKCNSLLPL
     DDIVRVVTHE DCVPEVKIAY INFLNHCYVD TEVEMKEIYT SNHMWKLFEN FLVDICRVCN
     STSDRKHADI VLERYVTEIV MSIVNTFFSS PFSDQSTTLQ ASKLAVVHQT RQPVFVQLLQ
     AIFRVYHCNW LLPSQKASVE SCIRVLSDVA KSRTIAIPVD LDSQVNNLFL KSHNIVQKTA
     MSWRMSVRNA ARRDSVLTAS RDYRNIIERL QDIVSSLEDR LRPLVQAELS VLVDVLHRPE
     LLFPENTDAR KKCESGQFIC KLIRHTKLLL EENEEKLCIK VLQTLREMMA KDRGFGDKGE
     ALRVILVNRY YGNIRPAGRR ESLTSFGNGP LSGGSSGKSG GGSIGSGSLS RSEMSLSDVQ
     CHLDKQGASD LVIDLIMNAT SDRVFHESIL LAIALLEGGN TTIQHSFFSR LTEDKKSEKF
     FKVFFDRMKV AQQEIKATVT VNTSDLGSKK RDEEQSERET PHRQRVREPS GQITEEAKEQ
     LIEASVATKK AYNSFRREAD PDDHFSLGEG VMAVAEKGRD ELEMSAVITI MQPILRFLQL
     LCENHNRDLQ NFLRCQNNKS NYNLVCETLQ FLDCICGSTT GGLGLLGLYI NEKNVALINQ
     TLESLTEYCQ GPCHENQNCI ATHESNGIDI ITALILNDIN PLGRKRMDLV LELKNNASKL
     LLAIMESRHD SENAERILYN MRPKELVEVI KKAYLQGEVE FEDGESGEDY AASPRNVGHN
     IYILAHQLAR HNKELQHMLK PGVQTGEGDE ALEFYAKHTA QIEIVRLDRT MEQIVFPVPS
     ICEFLTKESK LRIYYTTERD EQGSKIHDFF QRSEDLFNEM NWQKKLRAQQ VLYWCSRNMT
     FWSSISFNLA VLMNLLVAFF YPFVNVHGGT LDSRLSGLLW TAMLVSLAIV IVLPKPHGIR
     ALIASTILRL IFSIGLQPTL FLLGAFNVCN KIIFLTSFVG NRGTFTRGYG AMVLDVEFLY
     HLLYLLICAM GVFVHEFFYS LLLFDLVYRE ETLLNVIKSV TRNGRSIILT AVLALILVYL
     FSIVGYLFFK DDFILEVDRL QNETIFTENG GTMTSELLYP EVCRVGSDTN CTHEELAQVT
     EEEEEEKEHT CETLLMCIVT VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV
     IIIVLNLIFG VIIDTFADLR SEKQKKEEVL KTTCFICGLE RDKFDNKTVT FEEHFKEEHN
     MWHYLFFIVL VKVKDSTEYT GPESYVAEMI KDRNLDWFPR MRAMSLVSSD SEGEQNELRN
     LQEKLESTMR LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG QPAHLNINPQ QPA
//
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