UniProt: A0A1L8GID3

Database: UniProt
Entry: A0A1L8GID3_XENLA

LinkDB:  A0A1L8GID3_XENLA 
Original site:  A0A1L8GID3_XENLA

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   XENBASE (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (9)   
   InterPro (3)   
   Pfam (2)   
   PROSITE (3)   
   SMART (1)   
All databases (17)   

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ID   A0A1L8GID3_XENLA        Unreviewed;       616 AA.
AC   A0A1L8GID3;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   Name=zdhhc13.L {ECO:0000313|RefSeq:XP_018112746.1,
GN   ECO:0000313|Xenbase:XB-GENE-6488779};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018112746.1};
RN   [1] {ECO:0000313|RefSeq:XP_018112746.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018112746.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018112746.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004439}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
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DR   RefSeq; XP_018112746.1; XM_018257257.2.
DR   AlphaFoldDB; A0A1L8GID3; -.
DR   STRING; 8355.A0A1L8GID3; -.
DR   MaxQB; A0A1L8GID3; -.
DR   PaxDb; 8355-A0A1L8GID3; -.
DR   GeneID; 108713724; -.
DR   KEGG; xla:108713724; -.
DR   AGR; Xenbase:XB-GENE-6488779; -.
DR   CTD; 108713724; -.
DR   Xenbase; XB-GENE-6488779; zdhhc13.L.
DR   OMA; DVPDCNG; -.
DR   OrthoDB; 33889at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 108713724; Expressed in stomach and 19 other cell types or tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR24161:SF16; PALMITOYLTRANSFERASE ZDHHC13; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF01529; DHHC; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 4.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Membrane {ECO:0000256|RuleBase:RU079119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        285..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        309..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        340..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        367..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        463..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        512..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          418..550
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
SQ   SEQUENCE   616 AA;  69925 MW;  DA8BAA1005BAA6F2 CRC64;
     MSSPCKLPHG HSHQHSHHHH HHHGGPEEDP AAAVQNTAED YSNWDIVKAT QHGMLERCRE
     LVDAGYDVRQ PDKENVTLLH WAAINNRLEL VKYFISKGAI VDQLGGTLNS TPLHWAVRQG
     HLQMVIMLMR CGADPTLIDG EGYSSLHLAV LFQHLPIIAY LVSKGQSVDS PDMNGMTPLM
     LSAHRIIGLE PTNFLLKLNP SIHATDKVER NTALHWAVVS GNVNALDLLL ESGCNLDAVN
     AKGETPLEIA RQTRNRLTVH ILAGEAQMRS RRSSRIMKAL QQYEISLVSL MVLLIIWAVG
     YVLDMNTDSW LLKGTLLALL TAASQLFARH FIGYKSQKSL PAIFFSCSIF WMFLTWFIYF
     LPSLARMMFQ LPFIISMLFL FYFFYKTWST DPGYIKSSEE ESRQTIITLA EAGCLDGRLF
     CTSCLVKKPV RSMHCQTCNS CVARFDQHCM WTGQCIGAGN QHYFVLFLGS LSLVGNWMIY
     ATAVYWSDHC GVGSKKDGMW MMLSHMIDCS PWVLYMFCLV CTFTIWASLM LLVQLYQITF
     LGLTTQERIS LQVQNRHLKH QVSLRRTPFN RGCRQNLSDF FHCQCFGLIK SQQAIDWTKQ
     FHGGIPPARM RHPQTV
//

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